A5055958264- Cystic Fibrosis Research Advances
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Melanoma and MAPK Pathways
- Advanced biosensing and bioanalysis techniques
- Tracheal and airway disorders
- Synthesis and biological activity
- Antibiotic Resistance in Bacteria
- Cellular transport and secretion
- Plant biochemistry and biosynthesis
- Bacterial Genetics and Biotechnology
- Influenza Virus Research Studies
- Cutaneous Melanoma Detection and Management
- Sarcoidosis and Beryllium Toxicity Research
- Inhalation and Respiratory Drug Delivery
- Venomous Animal Envenomation and Studies
- Bacteriophages and microbial interactions
- Ion channel regulation and function
- Drug Transport and Resistance Mechanisms
- Microbial Metabolism and Applications
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2013-2024
University of Warsaw
2021-2024
Centre National de la Recherche Scientifique
2022
Institut Pasteur
2022
Université Paris Cité
2022
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a positive-strand RNA virus that causes severe syndrome in humans, which now referred to as coronavirus disease 2019 (COVID-19). Since December 2019, the new pathogen has rapidly spread globally, with over 65 million cases reported beginning of 2020, including 1.5 deaths. Unfortunately, currently, there no specific and effective treatment for COVID-19. As SARS-CoV-2 relies on its spike proteins (S) bind host cell-surface...
The yeast Saccharomyces cerevisiae can be a useful model for studying cellular mechanisms related to sterol synthesis in humans due the high similarity of mevalonate pathway between these organisms. This metabolic plays key role multiple processes by synthesizing and nonsterol isoprenoids. Statins are well-known inhibitors 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), enzyme cholesterol pathway. However, effects statins extend beyond their cholesterol-lowering action, since inhibition...
Mutations in the activation segment of v-raf murine sarcoma viral oncogene homolog B (BRAF) gene are present approximately 50% melanomas. The selective BRAF inhibitor vemurafenib has demonstrated significant clinical benefits patients with melanomas harboring most common mutations (V600E, V600K and V600R). However, activity inhibitors rare codon 600 surrounding codons not been documented. We used to treat a patient presenting p.V600_K601delinsD-mutated melanoma. An objective response was...
Toxin–antitoxin systems constitute a native survival strategy of pathogenic bacteria and thus are potential targets antibiotic drugs. Here, we target the Zeta–Epsilon toxin–antitoxin system, which is responsible for stable maintenance certain multiresistance plasmids in Gram-positive bacteria. Peptide ligands were designed on basis ε2ζ2 complex. Three α helices Zeta forming protein–protein interaction (PPI) site selected peptides conserving residues interacting with Epsilon antitoxin while...
New pathogens responsible for novel human disease outbreaks in the last two decades are mainly respiratory system viruses. Not different was pandemic episode, caused by infection of a severe acute syndrome coronavirus 2 (SARS-CoV-2). One extensively explored targets, recent scientific literature, as possible way rapid development COVID-19 specific drug(s) is interaction between receptor-binding domain virus' spike (S) glycoprotein and receptor angiotensin-converting enzyme (hACE2). This...
Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) are responsible for (CF). The most common CF-causing mutation is deletion of 508th amino-acid CFTR (F508del), leading to dysregulation epithelial fluid transport airway's epithelium and production a thickened mucus favoring chronic bacterial colonization, sustained inflammation ultimately respiratory failure. c407 bis-phosphinic acid derivative which corrects dysfunction cells carrying F508del mutation. This...