A5061255322- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Heart rate and cardiovascular health
- Coronary Artery Anomalies
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrest and Resuscitation
- Muscle Physiology and Disorders
- Cardiovascular Issues in Pregnancy
- Kawasaki Disease and Coronary Complications
- Cardiac electrophysiology and arrhythmias
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Otolaryngology and Infectious Diseases
- Inflammasome and immune disorders
- melanin and skin pigmentation
- Advanced Power Amplifier Design
- Porphyrin Metabolism and Disorders
Bambino Gesù Children's Hospital
2016-2025
Inova Fairfax Hospital
2021
European Hospital
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2017
Great Ormond Street Hospital
2017
University College London
2017
University of Rome Tor Vergata
2011-2015
The San Raffaele Telethon Institute for Gene Therapy
2011-2013
Sanquin
2011
University of Amsterdam
2011
Abstract Aims The extracardiac conduit-Fontan (ECC) has become the preferred technique for univentricular heart palliation, but there are currently no data on incidence of long-term arrhythmias. This study investigated arrhythmias and relation to single ventricle morphology in follow-up (FU) ECC. Methods results All patients with ECC performed our Centre between 1987 2017 were included (minimum FU 5 years). Of 353 consecutive patients, 303 [57.8% males, aging 8–50 (median 20) years at last...
Switched and IgM memory B cells execute different noninterchangeable functions. We studied in children of ages, peripheral blood spleen compared them with those born asplenic or unable to build germinal centers. show that, whereas switched are mostly generated the centers at all can be distinct three types developmental history. Innate cells, largest pool infants, by a center-independent mechanism. With age, if is present functional, innate remodelled accumulate somatic mutations. The third...
Since the spread of COVID-19, pediatric patients were initially considered less affected by SARS-COV-2, but current literature reported subsets children with multisystem inflammatory syndrome (MIS-C). This study aims to describe cardiac manifestation SARS-COV-2 infection in a large cohort admitted two Italian referral centers. Between March 2020 and 2021, we performed evaluation 294 (mean age 9 ± 5.9 years, male 60%) active or previous infection. Twenty-six showed ECG abnormalities: 63...
Abstract Vici syndrome is a rare congenital multisystem disorder characterized by agenesis of the corpus callosum, hypotonia, developmental delay, hypopigmentation, cataract, cardiomyopathy, and immunological abnormalities. Recurrent infections, mainly affecting respiratory tract, have been reported in majority cases, representing an important risk factor for morbidity mortality. The phenotype patients extremely variable, ranging from combined immunodeficiency to nearly normal immunity. We...
MIS-C is a multisystem inflammatory syndrome that characterized by multi-organ failure and cardiac involvement. The aim of this study was to describe the long-term cardiovascular outcome in cohort pediatric patients, who were admitted two Italian Pediatric Referral Centers. Sixty-seven patients (mean age 8.7 ± 4.7 years, male 60%) included; 65 (97%) them showed All completed one month follow-up, 47% 1 year it. ECG abnormalities present 65% them, arrhythmias 9% during an acute phase it...
Abstract Morbidity and mortality in Down syndrome (DS) are mainly related to congenital heart defects (CHDs). While CHDs with high prevalence DS (typical CHDs), such as endocardial cushion defects, have been extensively described, little is known about the impact of less common (atypical aortic coarctation univentricular hearts. In our single‐center study, we analyzed, observational, retrospective manner, data regarding cardiac features, surgical management, outcomes a cohort patients....
Whilst there has been significant public health benefits associated with global use of COVID-19 spike protein vaccines, potential serious adverse events following immunization have reported. Acute myocarditis is a rare complication COVID19 vaccines and often it self-limiting. We describe two cases experiencing recurrent mRNA vaccine despite prior episode full clinical recovery. Between September 2021-September 2022 we observed male adolescents related to mRNA-based-COVID19 vaccine. During...
We sought to evaluate the long-term survival and risk factors for morbidity mortality in our cohort of patients after extracardiac (EC) Fontan.We collected analysed follow-up data until September 2020 all who underwent EC Fontan operation at institution from November 1988 2015.Out 406 treated with a mean age 5.4 ± 4.5 years, 372 (91.6%) were discharged home; 15% lost follow-up. The median was 14.6 years (interquartile range 8.7-20.3). Two hundred (54%) had good outcome, an event-free...
Ataxia-Telangiectasia is a rare multisystem autosomal recessive disorder [OMIM 208900], caused by mutations in Mutated gene. It characterized neurological, immunological and cutaneous involvement. Granulomas have been previously reported patients, even if acne rosacea has not described. We report case of young patient with severe neurological involvement, who developed granulomatous skin lesions diagnosed biopsy as rosacea. Considering the clinical picture lack improvement to multiple topic...
Lamin A/C (LMNA) encodes for two nuclear intermediate filament proteins. Mutations in LMNA cause a highly heterogeneous group of diseases predominantly affecting striated and cardiac muscles, adipose tissue peripheral nerves. Laminopathies lead to muscular or disease, lipodystrophy syndromes, neuropathy, accelerated aging disorders. Cardiac involvement includes progressive arrhythmias (brady/tachyarrhythmias, SCD). Furthermore, cardiomyocyte damage often progresses into dilated...
Carvedilol is recommended for chronic heart failure (HF) treatment in children. However, the ideal dosage and administration are not standardized, data on its long-term effects lacking. This study aimed to assess effect of a high regimen carvedilol cardiac outcomes children with HF.We conducted retrospective cohort including all HF dilated cardiomyopathy. We analyzed medical records before starting treatment, at 1 3 years after reaching maximum therapeutic dosage. All were compared...
Multisystem inflammatory syndrome in children (MIS-C) is a serious health condition that imposes long-term follow-up. The purpose of our pilot study to evaluate the usefulness cardiopulmonary stress test (CPET) follow-up after MIS-C. All patients admitted for MIS-C hospital 12 months preceding date observation were considered inclusion study. Pre-existing cardio-respiratory diseases and/or lack collaboration exclusion criteria. At enrolment, each subject passed cardiological examination,...
Pediatric patients with cardiomyopathies are at risk of malignant arrhythmias and sudden cardiac death (SCD). An ICD may prevent SCD. The aim this study was to evaluate implantation outcomes, compare transvenous subcutaneous ICDs (S-ICDs) implanted in pediatric cardiomyopathies.The is single center retrospective, includes who required (2010-2021). Outcomes were recorded for appropriate/inappropriate therapy surgical complications. Transvenous S-ICD compared. Data presented as median values...
An elevated heart rate is associated with an increased risk of death or cardiac transplant in children dilated cardiomyopathy (DCM). Whether a clinical marker to address therapy, poorly investigated children.