A5037436119- Pleural and Pulmonary Diseases
- Trauma Management and Diagnosis
- Lung Cancer Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Congenital Diaphragmatic Hernia Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Pneumothorax, Barotrauma, Emphysema
- Neuroendocrine Tumor Research Advances
- Emergency and Acute Care Studies
- Respiratory Support and Mechanisms
- Cancer Cells and Metastasis
- Occupational and environmental lung diseases
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Infectious Diseases and Tuberculosis
- Cancer Diagnosis and Treatment
- Abdominal Trauma and Injuries
- RNA modifications and cancer
- Tracheal and airway disorders
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- HER2/EGFR in Cancer Research
- Esophageal Cancer Research and Treatment
- Microbial Inactivation Methods
Evangelisches Krankenhaus Bielefeld
2009-2024
Bielefeld University
2021-2024
Forschungsverbund Berlin
2021
Bethel University
2019-2020
Bethel Baptist Hospital
2020
Otto-von-Guericke University Magdeburg
2009-2010
University Hospital of Bern
2003-2009
University Hospital Magdeburg
2009
Abstract Objectives Thoracic trauma (TT) is the third most common cause of death after abdominal injury and head in polytrauma patients. Its management still a very challenging task. The purpose this study was to analyse risk factors affecting outcome high-volume centre efficacy specialised team level 1 centres. Patients methods Between January 2003 December 2012, data all patients admitted accident emergency (A&E) department were prospectively collected at German Trauma Registry (GTR)...
We observed a remarkable increase in the number of young patients who presented with lung emphysema and secondary spontaneous pneumothorax (SSP) at our institution for over period 30 months; most them have common history marijuana abuse.Retrospective case series.Seventeen bullous were systematically evaluated months. All regular smokers. Clinical history, chest X-ray, CT-scan, function test, laboratory histological examinations assessed. compared findings this group (group I) non-marijuana...
The increased application of in vitro systems pharmacology and toxicology requires cell culture that facilitate the cultivation process ensure stable, reproducible controllable conditions. Up to now, some devices have been developed for cells under submersed However, meeting requirements an air-liquid interface (ALI) special needs bronchial epithelial example are still lacking. In order obtain vivo like organization differentiation these they need be cultivated ALI conditions on microporous...
The following database integrates results from published proteomics studies in human non-small cell lung cancer (NSCLC), with a focus on squamous cancers (SCC) and adenocarcinomas (AC).Only NSCLC were analyzed. Results 12 available, 5 SCC, 4 AC, 1 AC 2 without further distinction. Human tissues, paired normal patient's sera, sera or tumor lines Three technologies applied: two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), differential in-gel (DIGE) serological proteome analysis...
Cancer stem cells (CSCs) are crucial mediators of tumor growth, metastasis, therapy resistance, and recurrence in a broad variety human cancers. Although their biology is increasingly investigated within the distinct types cancer, direct comparisons CSCs from different allowing comprehensive mechanistic insights rarely assessed. In present study, we isolated endometrioid carcinomas, glioblastoma multiforme as well adenocarcinomas lung prostate assessed global transcriptomes using full-length...
There is growing evidence that cancer stem cells (CSCs), a small subpopulation of self-renewal cells, are responsible for tumor growth, treatment resistance, and relapse thus enormous clinical interest. Here, we aimed to isolate new CSC-like derived from human primary non-small cell lung (NSCLC) specimens analyze the influence different inhibitors NF-κB MYC signaling on survival. were established three squamous carcinomas (SCC) adenocarcinomas (AC) shown express common CSC markers such as...
Background: Diaphragm eventration (DE) represents a frequent problem with consecutive major impacts on respiratory function and the quality of life patients. The role diaphragmatic plication (DP) is still underestimated. aim present study to evaluate efficacy minimally-invasive surgical for management unilateral eventration, best our knowledge, this largest series reported in literature using non-resectional technique. Methods: All patients paralysis admitted between January 2008 December...
A 73-year-old woman was admitted with bilateral pulmonary nodules, one on each side, which were suspected to be metastases of an unknown primary tumor. Enucleation the lesion in upper right lobe performed. The histological examination showed a typical carcinoid subsequent octreotid scan revealed high suspicion left lower as well. Formal lobectomy and performed staged procedures. radiological 1 year control CT-scan demonstrated no further pathological lesions. To best our knowledge this is...
Pain control after thoracotomy is an important issue that affects the outcome in thoracic surgery. Intercostal nerve preservation (ICNP) has increased interest outcomes of conventional thoracotomy. The current study critically evaluates role intercostal early and late pain its benefit patients undergoing thoracotomy.Data obtained prospectively between January 2006 December 2010 by a colleague at our division General Thoracic Surgery were retrospectively analysed. There 491 who underwent...
Bronchus stump insufficiency (BSI) is one of the major complications after pneumonectomy; we analyzed all patients who underwent extra pleural pneumonectomy (EPP) for malignant mesothelioma (MPM) in order to detect role muscle flap (MF) on preventing early and late insufficiency. From January 2000 until December 2005, there were 42 admitted with MPM further intervention at our institution. Thirty suitable surgery thus received a multimodal treatment neo-adjuvant chemotherapy using Cisplatin...
Abstract Rationale: Neuroendocrine tumors (NETs) of the lung account for 5% all cases cancer, which itself is leading cause cancer-related death worldwide. In accordance to its rarity, only few cell lines NETs exist, even often lack key characteristics primary tumor, making it difficult study underlying molecular mechanisms. Patient concerns: The patient reported in this case a 71-year old woman, never smoked but suffered under dry cough. diagnoses: Chest CT-scan showed paracardiac nodule...
The aim of this study was to determine the influence comorbidity on outcome after pulmonary resection in patients over 75 years old. Three hundred and thirty-three with non-small-cell lung cancer operated between 1998 2002 were divided into 3 age groups: < 60 (group 1), 60–75 2), > 3). Overall operative mortality 0.3%; 30-day 1%. There more major complications re-operation groups 1 2, but minor occurred significantly frequently group (36% vs 16%). mean hospital stay 12 days, no...
Abstract Survivin is an inhibitor of apoptosis as well a promoter cell proliferation. Fibulin-3 matrix glycoprotein that displays potential for tumor suppression or propagation. The present study aimed to validate the expression levels survivin and fibulin-3 in benign malignant respiratory diseases. This case–control included 219 patients categorized into five groups. Group A 63 with lung cancer, group B various diseases, D 45 pleural mesothelioma (MPM), E 48 C 60 healthy individuals...
Objective: During surgery for colon carcinoma, tumour cells may spread into the blood and lead to development of distant metastases. The most frequent sites metastases are liver lungs. A new therapeutic approach is required prevent implantation freely circulating during after treat established aim this prospective study was observe influence long-term intravenous taurolidine on lung injection adenocarcinoma cells. Methods: Tumour (DHD/K12/TRb cell line, 1 × 106 cells) were injected right...
One of the most frequently seen lethal causalities is thoracic trauma (TT). We aim to distinguish risk factors affecting outcome TT find best way for its management. Over a 12-year data were collected and retrospectively analyzed patients with TT. Two patients' groups involved: Group I: managed between January 2003–December 2008. II: 2009–December 2014. Risk analyzed. A total number 630 cases admitted. I included 285 (197 males, their mean age 46 years). 345 in II (251 49 Higher score (TTS),...