A5029633892- Advanced MRI Techniques and Applications
- Fatigue and fracture mechanics
- High Temperature Alloys and Creep
- Proteins in Food Systems
- Web and Library Services
- Medical Imaging Techniques and Applications
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Smart Grid Security and Resilience
- Polysaccharides Composition and Applications
- Food Chemistry and Fat Analysis
- Advanced Proteomics Techniques and Applications
- Advanced Biosensing Techniques and Applications
- Cancer-related gene regulation
- Water Quality Monitoring Technologies
- Fault Detection and Control Systems
- Cloud Computing and Resource Management
- Medical Image Segmentation Techniques
- Microencapsulation and Drying Processes
- Microplastics and Plastic Pollution
- Lipid metabolism and biosynthesis
- Culinary Culture and Tourism
- Influenza Virus Research Studies
- Enterobacteriaceae and Cronobacter Research
- Consumer Attitudes and Food Labeling
University of Dundee
2024-2025
Southwest University
2024
Wellcome Centre for Anti-Infectives Research
2024
Huazhong Agricultural University
2016-2021
University of Milan
2018-2019
Wuxi Wind Power Design and Research Institute
2018
State Key Laboratory of Food Science and Technology
2017
Jiangnan University
2017
Intel (United States)
2016
Deakin University
2016
Nwat-MMGBSA is a variant of MM-PB/GBSA based on the inclusion number explicit water molecules that are closest to ligand in each frame molecular dynamics trajectory. This method demonstrated improved correlations between calculated and experimental binding energies both protein-protein interactions ligand-receptor complexes, comparison standard MM-GBSA. A protocol optimization, aimed maximize efficacy efficiency, discussed here considering penicillopepsin, HIV1-protease, BCL-XL as test...
Cryptosporidiosis is a diarrheal disease caused by infection with Cryptosporidium spp. parasites and leading cause of death in malnourished children worldwide. The only approved treatment, nitazoxanide, has limited efficacy this at-risk patient population. Additional safe therapeutics are urgently required to tackle unmet medical need. However, the development anti-cryptosporidial drugs hindered lack understanding optimal compound properties treat gastrointestinal infection. To address...
The maturation of the RNA cap involving guanosine N-7 methylation, catalyzed by HsRNMT (RNA guanine-7 methyltransferase)-RAM guanine-N7 methyltransferase activating subunit) complex, is currently under investigation as a novel strategy to combat PIK3CA mutant breast cancer. However, development effective drugs hindered limited understanding enzyme's mechanism and lack small molecule inhibitors. Following elucidation HsRNMT-RAM molecular mechanism, we report biophysical characterization two...
Sixty percent of milk consumed in China has a long shelf life (UHT), presumably because with short (pasteurized) is comparatively expensive. This contrast to Australia, where 10% UHT and the price between pasteurized equivalent. Whether actually more liked than by Chinese consumers unknown. However, potential positive halo around expensive might result liking when it labeled as "short shelf-life milk." To test these hypotheses, (n=48, 20 males, 28 females, 23 ± 7.2 yr) Australian (n=93, 11...
A novel molecular scaffold has been synthesized, and its synthesis incorporation into new analogues of biologically active molecules will be discussed. comparison the inhibitory activity these compounds to known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) shown.
Abstract The human inducible phospho-fructokinase bisphosphatase isoform 3, PFKFB3, is a crucial regulatory node in the cellular metabolism. enzyme an important modulator regulating intracellular fructose-2,6-bisphosphate level. PFKFB3 bifunctional with exceptionally high kinase to phosphatase ratio around 740:1. Its activity can be directly inhibited by small molecules acting on active site. On other hand, here we propose innovative and indirect strategy for modulation of activity, achieved...
Characterize the phosphate‐specific transport system in Cronobacter sakazakii BAA‐894. The genes relevant to phosphate transfer C. BAA‐894 were determined by using sequence alignment corresponding Escherichia coli. Then, pst operon was deleted lambda Red recombination system. Using wild type as a control, membrane permeability, auto‐aggregation, exopolysaccharide biosynthesis, biofilm formation, and adhesion ability of mutant ▵pst grown media containing high or low concentrations...
With the potential of improving virtual screening outcome, MM-PB/GBSA has become a disputed method that requires extensive testing and tuning to provide optimal results. One factors is internal or solute dielectric constant. We have applied three test sets with receptors different categories libraries from sources investigate underlying issue related this discovered increasing value does not improve enrichment qualitatively. More interestingly, nonpolar polar calculated energies act...
Energy Internet provides important support to power transmission and substation distribution links, security is particularly significant. However, access authentication centralized the certification center has brought great pressure on computing communications. In this paper, a distributed scheme for energy proposed based blockchain technology, which decentralized undeniable. A PBFT consensus mechanism implemented with Shamir threshold secret sharing mechanism. Experiments show that can...
The maturation of the RNA cap involving guanosine N-7 methylation, catalyzed by HsRNMT (RNA guanine-7 methyltransferase)-RAM guanine-N7 methyltransferase activating subunit) complex, is currently under investigation as a novel strategy to combat PIK3CA mutant breast cancer. However, development effective drugs hindered limited understanding enzyme's mechanism and lack small molecule inhibitors. Following elucidation HsRNMT-RAM molecular mechanism, we report biophysical characterization two...
This paper is to address the resource utilization problem for high-performance data processing applications in a large IDC (Internet Data Center) environment. On one hand, each application calls best-fit infrastructure with specific compute-storage ratio, achieve highest while meeting its performance requirement. And such ratio varies among applications. other IDCs have always been trying unify infrastructures lower TCO (Total Cost of Ownership). Therefore, it’s getting harder and adapt...
Hosts: Wuhan University School of Information Management and the Sungkyunkwan Library & Science Data Department