A5007346393- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Cardiovascular Health and Disease Prevention
- Muscle Physiology and Disorders
- Hormonal and reproductive studies
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Sports Performance and Training
- Pharmacology and Obesity Treatment
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Diet and metabolism studies
- High Altitude and Hypoxia
- Pharmacological Effects and Assays
- GDF15 and Related Biomarkers
- Metabolism, Diabetes, and Cancer
- Physiological and biochemical adaptations
- Blood Pressure and Hypertension Studies
- Sports injuries and prevention
- Atherosclerosis and Cardiovascular Diseases
- Algal biology and biofuel production
- Body Composition Measurement Techniques
Kumamoto University
2022-2025
Japan Society for the Promotion of Science
2019-2024
Ritsumeikan University
2015-2024
Kyorin University
2017
Kobe University
2016
Tokyo Institute of Technology
2008
Aerobic training (AT) and high-intensity intermittent (HIIT) reduce arterial stiffness, whereas resistance (RT) induces deterioration of or no change in stiffness. However, the molecular mechanism these effects different exercise modes remains unclear. This study aimed to clarify difference on endothelial nitric oxide synthase (eNOS) signaling pathway stiffness rats humans.In animal study, forty 10-wk-old male Sprague-Dawley were randomly divided into four groups: sedentary control (CON), AT...
Abstract High-intensity intermittent exercise training (HIIT) has been proposed as an effective approach for improving both, the aerobic and anaerobic capacity. However, detailed molecular response of skeletal muscle to HIIT remains unknown. We examined effects on global gene expression in human muscle. Eleven young healthy men participated study completed a 6-week program involving exhaustive 6–7 sets 20-s cycling periods with 10-s rests. In addition determining maximal oxygen uptake (...
Increased complement component 1q (C1q) secretion with aging leads to muscle fibrosis and atrophy whereas resistance training attenuates circulating C1q levels. This study aimed clarify whether exercise-induced reduction of contributes the inhibition in aged muscles. Young (13-wk-old) (38-wk-old) senescence-accelerated mouse prone 1 mice were randomly assigned one 4 groups: a young or sedentary control group, (climbing ladder 3 d/wk for 12 wk) group. We found that ameliorated mice,...
Mammalian aging is reportedly driven by the loss of epigenetic information; however, its impact on skeletal muscle remains unclear. This study shows that mouse exhibits increased DNA methylation, and overexpression methyltransferase 3a (Dnmt3a) induces an aging-like phenotype. Muscle-specific Dnmt3a leads to increase in central nucleus-positive myofibers, predominantly fast-twitch fibers, a shift toward slow-twitch elevated inflammatory senescence markers, mitochondrial OXPHOS complex I...
Abstract Ground calibration experiments of the SELENE high sensitivity fluxgate Lunar Magnetometer (LMAG) have been performed in order to determine alignment, sensitivity, and offset sensors (MGF-S). It is checked out that are orthogonal each other within 0.4 degrees, linearity ambient magnetic field output from confirmed. Also, temperature dependences examined but no clear signatures dependencies can be seen. has an in-flight system direction magnetometer routinely. The fields generated by...
This study aimed to clarify whether muscle-derived irisin secretion induced by aerobic exercise training is involved in reduction of arterial stiffness via nitric oxide (NO) productivity obesity. In animal study, 16 Otsuka Long-Evans Tokushima Fatty (OLETF) rats with obesity were randomly divided into 2 groups: sedentary control (OLETF-CON) and 8-week treadmill (OLETF-EX) groups. human 15 subjects completed for 45 min at 60%–70% peak oxygen uptake intensity 3 days/week. As a result...
Adiponectin regulates endothelial nitric oxide synthase in cells, and body fat loss by aerobic exercise training promotes adiponectin secretion. Recently, C1q/tumor necrosis factor-related proteins (CTRPs) have been identified as novel adipokines are paralogs of adiponectin, but the association between training-induced reduction arterial stiffness circulating CTRPs levels remains unclear. This study aimed to clarify whether middle-aged older adults is associated with change serum induced...
Background Adropin is a peptide hormone that promotes nitric oxide (NO) production via activation of endothelial NO synthase (eNOS) in cells. Its circulating levels are reduced with aging and increased aerobic exercise training (AT). Using mouse model, we hypothesized AT restores aging-associated reductions arterial adropin improves adropin-induced NO-dependent vasorelaxation. Further, these findings would be consistent data obtained elderly humans. Methods Results In the animal study,...
Effects of increase in muscle 5α-dihydrotestosterone (DHT) levels caused by resistance exercise on regulation mammalian target rapamycin (mTOR)- and glucose transporter 4 (GLUT4)-signaling pathways type 2 diabetic rats were assessed. Twenty-week-old randomly divided into the resting control, immediately, 1 hour, or 3 hours after exercise, with without pretreatment 5α-reductase inhibitor. Immediately hour DHT as well phosphorylation AMP-activated protein kinase (AMPK), TBC1 domain family...
Abstract This study investigated the effects of white meat, such as chicken, intake combined with resistance training on muscle mass and strength in elderly women, whether underlying mechanism involves changes gut microbiota. Ninety‐three volunteers (age 59–79 years) were randomly allocated to sedentary control placebo (Sed + PL) or chicken meat HP) (RT HP). Resistance sessions performed 3 d/week for 12 weeks using leg extensions curls. Boiled (110 g, containing 22.5 g protein) was ingested...
The purpose of this study was to investigate the effect chronic chlorella intake alone or in combination with high-intensity intermittent exercise (HIIE) training on performance and muscle glycolytic oxidative metabolism rats. Forty male Sprague-Dawley rats were randomly assigned four groups: sedentary control, (0.5% powder normal feed), HIIE training, for 6 wk (n = 10 each group). comprised 14 repeats a 20-s swimming session 10-s pause between sessions, while bearing weight equivalent 16%...
Chronic resistance exercise induces improved hyperglycemia in patients with type 2 diabetes mellitus. Musclin, a muscle-derived secretory factor, is involved the induction of insulin via downregulation glucose transporter-4 (GLUT-4) signaling pathway skeletal muscles. However, whether musclin affects mechanism remains unclear. This study aimed to clarify decreased secretion chronic improvement GLUT-4 rats diabetes. Male, 20-week-old, Otsuka Long-Evans Tokushima Fatty (OLETF) rats, model,...
Regular resistance exercise induces skeletal muscle hypertrophy and improvement of glycemic control in type 2 diabetes patients. Administration dehydroepiandrosterone (DHEA), a sex steroid hormone precursor, increases 5α-dihydrotestosterone (DHT) synthesis is associated with improvements fasting blood glucose level hypertrophy. Therefore, the aim this study was to investigate whether increase DHT levels, induced by chronic exercise, can contribute concomitant muscular metabolism diabetic...
Abstract Follistatin‐like 1 (FSTL1), which is mainly secreted from skeletal muscle and myocardium, upregulates protein kinase B (Akt) endothelial nitric oxide synthase (eNOS) phosphorylation in vascular cells. It unclear whether muscle‐ myocardium‐derived FSTL1 secretion induced by aerobic exercise training involved the reduction of arterial stiffness via NO production obese rats. This study aimed to clarify training‐induced myocardium associated with a Akt‐eNOS signaling pathway Sixteen...
Administration of dehydroepiandrosterone (DHEA), a precursor sex steroid hormones, reduces total and visceral fat mass elevates adipocytic adiponectin gene expression. The aim this study is to investigate whether levels peroxisome proliferator-activated receptors (PPARs) in muscle transcription PPAR target genes are affected by long-term DHEA administration or exercise training, altered associated with circulating level obese rats. After 14 weeks on high-sucrose diet, male Wistar rats were...
Abstract Background Resistance training is a well‐known exercise therapy for preventing and improving lacks of muscle mass, strength, quality with advances in age; however, its effects on arterial stiffness are not beneficial. Additionally, higher intake protein, which an effective nutrient health, results lower stiffness. Whether the combination moderate to high‐intensity resistance high‐protein would improve cancel training‐induced increase elderly women remains unclear. Methods...
Age-induced chronic inflammation is prevented by aerobic and resistance exercise training. However, the mechanism of effects on in each tissue remains unclear. The aim this study was to investigate training gene expression profiles for macrophage infiltration polarization (M1/M2 ratio) with various tissues aged mice. Male 38-week-old SAMP1 mice were randomly divided into three groups, namely, sedentary-control (Aged-Con), (Aged-AT; voluntary running), 12-weeks (Aged-RT; climbing ladder)....
Our previous study showed that lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production is inhibited by acute exhaustive exercise in mice, leading to transient immunodepression after exercise. Sparassis crispa (SC), an edible mushroom, has immunopotentiative properties. This aimed clarify the effects of SC intake on reduced LPS-induced TNF-α upon mice. Male C3H/HeN mice were randomly divided into three groups: normal chow + resting sedentary, treadmill running exercise, and...
Muscle fiber conduction velocity (CV) has been developed to estimate neuromuscular fatigue and measured during voluntary (VC) electrically evoked (EC) contractions. Since CV VC EC reflect different physiological phenomena, the two parameters would show inconsistent changes under conditions of fatigue. We investigated time-course after fatiguing exercise.In 14 young males, maximal contraction (MVC) knee extensor muscles, electrical stimulation (CV-EC) MVC (CV-VC) were before immediately, 30...
Chronic Chlorella intake and aerobic exercise training reduce arterial stiffness increase circulating nitric oxide (NO) levels, which has beneficial effects. This study aimed to clarify the combined aortic NO-mediated effects of chronic on endothelial vasorelaxation in aged mice. In this study, 38-week-old male senescence-accelerated mouse prone 1 (SAMP1) mice were divided into sedentary control (Con), (AT; voluntary wheel running for 12 weeks), (CH; 0.5% powder normal diet), AT CH (AT+CH)...