A5021565277- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Protein purification and stability
- Renal cell carcinoma treatment
- Dysphagia Assessment and Management
- Cancer Diagnosis and Treatment
- Voice and Speech Disorders
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Dental Trauma and Treatments
- CAR-T cell therapy research
- Pancreatic function and diabetes
- Gastrointestinal Tumor Research and Treatment
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Oral and gingival health research
Osaka Dental University
2016-2024
Miwa Hospital
2023
Tohoku University
2013-2022
Aichi Gakuin University
2021-2022
Sendai Medical Center
2021-2022
Takeda (Japan)
2014-2018
Suzuka University of Medical Science
2016-2018
Graduate School USA
2014
American Gastroenterological Association
2014
Kumamoto University
2006
Abstract Background/purpose Hilar cholangiocarcinoma and intrahepatic involving the hepatic hilus are defined as “perihilar cholangiocarcinoma”. The principle of surgical treatment is hemi‐hepatectomy or trisectionectomy liver, caudate lobectomy, resection extrahepatic bile duct for complete tumor. aim this study was to review outcomes major hepatectomy perihilar cholangiocarcinoma. Methods Using Kaplan–Meier method Cox proportional hazards model, we analyzed results in 125 patients with who...
Refractory chronic pain dramatically reduces the quality of life patients. Existing drugs cannot fully achieve effective control because their lower efficacy and/or accompanying side effects. Voltage-gated potassium channels (KCNQ) openers have demonstrated analgesic effect in preclinical and clinical studies, are thus considered to be a potential therapeutic target as analgesics. However, these exhibit narrow window due imposed central nerve system (CNS) To clarify by peripheral KCNQ...
Objectives Pancreatic cancer is one of the most lethal malignancies; its poor prognosis strongly associated with invasion and metastasis. Expression S100A4 has been reported to correlate in various cancers. We have investigated role pancreatic tumorigenesis clinicopathologic significance. Methods Protein expression was examined by Western blot cell lines a human ductal epithelium line, HPDE-6. Then expressions S100A4, TP53, CD133 were immunohistochemically resected specimens from 83 patients...
Abstract Purpose: Bispecific antibodies (BsAb) have been exploited as both cancer immunodiagnostics and therapeutics show promise in clinical trials of imaging therapy. For development BsAbs reagents, we focused on construction small recombinant BsAbs, called bispecific diabodies. Here, constructed characterized a humanized diabody. Experimental Design: We reported significant antitumor activity an anti-epidermal growth factor receptor (EGFR) × anti-CD3 diabody (Ex3) vitro cytotoxicity...
We previously reported the marked in vitro and vivo antitumor activity of hEx3, a humanized diabody (small recombinant bispecific antibody) with epidermal growth factor receptor (EGFR) CD3 retargeting. Here, we fabricated tetravalent IgG-like antibody two kinds single-chain Fv (scFv), i.e. anti-EGFR scFv anti-CD3 scFv, that contains same four variable domains as on platform human IgG1 (hEx3-scFv-Fc). hEx3-scFv-Fc prepared from mammalian cells showed specific binding to both EGFR target...
The domains of bispecific diabodies (BsDbs) can be ordered in four different ways; however, the influence domain order on cytotoxicity BsDbs that retarget immune cells against tumor had not been addressed. We previously reported marked antitumor effects a humanized BsDb targets epidermal growth factor receptor and CD3 (hEx3-Db). Here, we rearranged hEx3-Db to examine function BsDbs. successfully prepared homogenous dimers all configurations. Interestingly, three hEx3s inhibited cancer more...
Abstract Pancreatic cystic neoplasms (PCNs) are a heterogeneous group with varying risks of malignancy. To explore the clinical utility liquid biopsy in cyst type classification, we analyzed GNAS/KRAS mutations circulating cell-free DNA (cfDNA) obtained from 57 patients histologically diagnosed PCNs, including 34 intraductal papillary mucinous (IPMNs) and compared mutant allele prevalence variant patterns paired resected specimens using next-generation sequencing. The positive GNAS cfDNA...
Little is known about the roles of Notch signaling in cholangiocarcinoma (CC). The expression hairy and enhancer split 1 (Hes-1) has not been investigated yet resected specimens CC. reported to be related cancer stem cell (CSC) like properties some malignancies. Our aim investigate participation extrahepatic CC (EHCC) evaluate efficacy cells with CSC-like by blockade. First, Notch1, 2, 3, 4 Hes-1 was examined immunohistochemistry 132 EHCC specimens. clinicopathological characteristics...
Background: This study was performed to investigate the oncologic role of lymph node (LN) management and propose a surgical strategy for treating intrahepatic cholangiocarcinoma (IHCC). Methods: The medical records patients with resected IHCC were retrospectively reviewed from multiple institutions in Korea Japan. Short-term long-term outcomes analyzed according metastasis (LNM). A nomogram predict LNM established managing IHCC. Results: total 1138 enrolled. Of these, 413 underwent LN 725...
Abstract Purpose To elucidate the effectiveness of circulating tumor DNA (ctDNA) for predicting occult metastases in patients with pancreatic cancer without apparent metastases. Methods Circulating was obtained from plasma samples 165 and analyzed using droplet digital PCR. The prevalence allele frequencies ctDNA were compared across different patterns degrees metastatic spread. Results Of 142 who underwent abdominal exploration, 39 (27.5%) harbored including positive peritoneal lavage...
We previously reported the construction and activity of a humanized, bispecific diabody (hEx3) that recruited T cells towards an epidermal growth factor receptor (EGFR) positive tumor. Herein, we describe second functional, fully anti-EGFR recruits another subset lymphocyte effectors, natural killer cells, to EGFR-expressing tumor cells. After confirmed × anti-CD16 (Ex16) consisting humanized variable fragment (Fv) mouse Fv had inhibitory activity, designed construct Ex16 (hEx16). However,...
The aim of this study was to evaluate the diagnostic and prognostic impact systemic inflammatory markers for IPMN with high-grade dysplasia (HGD)/invasive carcinoma.Neutrophil-to-lymphocyte ratio (NLR), derived NLR, platelet-to-lymphocyte ratio, C-reactive protein-to-albumin were compared across different histological grades 205 cases. We also tested performance HGD/invasive carcinoma.The median (interquartile range) preoperative NLR higher in carcinoma (2.03 [1.48-2.93]) than low-grade...
The Frey procedure, the coring out of pancreatic head and longitudinal pancreaticojejunostomy, is a safe, easy, reliable method to solve most problems associated with chronic pancreatitis. During long-term follow up, unexpected relapse in tail was encountered. pattern failure rationale for new procedure treat or prevent such were investigated.From 1992 2008, 71 patients pancreatitis underwent at Tohoku University Hospital. etiology alcoholic 92.6% them, followed incidence by idiopathic...
The differentiation between pancreatic head cancer (PHC) and distal cholangiocarcinoma (DCC) can be challenging because of their anatomical histopathological similarity. This is an important problem, the distinction has implications for treatment these malignancies. However, there are no biomarkers differential diagnosis PHC DCC. present study aimed to identify novel diagnostic immunohistochemical distinguish from Liquid chromatography tandem mass spectrometry (LC-MS/MS) was employed detect...
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignant mesenchymal tumor that usually occurs in children and rarely diagnosed adults. Here, we describe case 65-year-old woman who presented with huge cystic lesion liver. Laboratory studies performed on admission showed modest inflammation, poor nutrition, elevated levels total bilirubin, alkaline phosphatase, γ-glutamyl transferase. Computed tomography well-defined, heterogeneous multiple cysts involving right lobe medial...
Abstract Aim This study aimed to clarify the usefulness of tumor markers from peritoneal lavage in selecting patients with a high risk recurrence and predicting site‐specific pancreatic cancer. Methods The levels serum carcinoembryonic antigen (CEA) carbohydrate (CA) 19–9 (sCEA/sCA 19–9) paired CEA CA (pCEA/pCA were measured 90 cancer who underwent surgery. Using cutoff values determined by maximally selected rank statistics for disease‐free survival (DFS), its patterns evaluated combination...