A5102985505- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Head and Neck Cancer Studies
- Trauma Management and Diagnosis
- Medical Imaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Diagnosis and Treatment
- Pneumothorax, Barotrauma, Emphysema
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Pain Management and Treatment
- Global Cancer Incidence and Screening
- Smoking Behavior and Cessation
- Radiation Therapy and Dosimetry
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dementia and Cognitive Impairment Research
- Geochemistry and Geologic Mapping
- Autoimmune and Inflammatory Disorders Research
- Animal Genetics and Reproduction
- NMR spectroscopy and applications
- Functional Brain Connectivity Studies
- Voice and Speech Disorders
Georgetown University
2015-2025
Georgetown University Medical Center
2001-2025
Pain Management Institute
2024
Medical College of Wisconsin
2024
MedStar Georgetown University Hospital
2003-2023
Texas Christian University
2023
Bradley University
2023
Cleveland Clinic
2001-2023
University of Washington
2007-2023
University of Utah Hospital
2023
Curative surgery is not an option for many patients with clinical stage I non-small-cell lung carcinoma (NSCLC), but radical radiosurgery may be effective. Inoperable small peripheral NSCLC were enrolled in this study. Three-to-five fiducial markers implanted or near tumors under CT guidance. Gross tumor volumes (GTVs) contoured using windows. The GTV margin was expanded by 5 mm to establish the planning treatment volume (PTV). A dose of 42–60 Gy delivered PTV 3 equal fractions less than 2...
Recent developments in radiotherapeutic technology have resulted a new approach to treating patients with localized lung cancer. We report preliminary clinical outcomes using stereotactic radiosurgery real-time tumor motion tracking treat small peripheral tumors.Eligible were treated over 24-month period and followed for minimum of 6 months. Fiducials (3-5) placed or near tumors under CT-guidance. Non-isocentric treatment plans 5-mm margins generated. Patients received 45-60 Gy 3 equal...
Abstract Objective To report serial 18F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET)/computed (CT) tumor response following CyberKnife radiosurgery for stage IA non-small cell lung cancer (NSCLC). Methods Patients with biopsy-proven inoperable NSCLC were enrolled into this IRB-approved study. Targeting was based on 3-5 gold fiducial markers implanted in or near tumors. Gross volumes (GTVs) contoured using windows; margins expanded by 5 mm to establish the planning...
Abstract Background Lung cancer mortality is reduced via low-dose computed tomography screening and treatment of early-stage disease. Evidence-based smoking cessation in the lung setting can further reduce mortality. We report results a trial from National Cancer Institute’s Smoking Cessation at Examination collaboration. Methods Eligible patients (n = 818) aged 50-80 years were randomly assigned (May 2017-January 2021) to intensive vs minimal arms (8 3 phone sessions plus 8 2 weeks nicotine...
Successful treatments for intractable chronic low back pain (CLBP) in patients who are not eligible surgical interventions scarce. The superior efficacy of differential target multiplexed spinal cord stimulation (DTM SCS) to conventional SCS (Conv-SCS) on the treatment CLBP with persistent syndrome (PSPS) have failed (PSPS-T2) motivated evaluation DTM versus Conv-SCS PSPS non-surgical candidates (PSPS-T1).
Abstract Although bronchial artery embolization (BAE) initially emerged as a critical minimally invasive image-guided procedure to manage massive hemoptysis regardless of underlying etiologies, there has been growing interest in BAE treat pulmonary malignancies within recent years. This article provides an in-depth exploration anatomy, pathologies, imaging modalities guiding effective BAE, and procedural pearls for successful intervention. The complexity including its variations potential...
The RNA genome segment order, nucleotide sequence and the putative encoded proteins were determined for infectious salmon anaemia virus (ISAV). Eight segments of genomic viral between 1·0 2·4 kb in length identified. 1–6 each had a predicted single open reading frame encoding P1, PB1, NP, P2, P3 HA proteins, respectively. Segment 7 P4/P5 8 P6/P7 proteins. Seven virion with molecular masses 25 72 kDa found by SDS–PAGE analysis. 42 immunoreactive ISAV antiserum from Atlantic salmon. mass...
To report clinical efficacy and toxicity of fractionated CyberKnife radiosurgery for the treatment hilar lung tumors.Patients presenting with primary metastatic tumors, treated using system Synchrony fiducial tracking technology, were retrospectively reviewed. Hilar location was defined as abutting or invading a mainstem bronchus. Fiducial markers implanted by conventional bronchoscopy within adjacent to tumors serve targeting references. A prescribed dose 30 40 Gy gross tumor volume (GTV)...
Radiotherapy of central lung tumors carries a higher risk treatment-related toxicity and local failure. In the era aggressive oligometastic management exploration proper dose-fractionation for metastatic is essential.Patients diagnosed with high-risk lesions pulmonary tree comprised this single-institutional retrospective analysis. "High-risk" were defined as those abutment and/or invasion mainstem bronchus. All patients treated using CyberKnife SBRT system in 5 fractions to total dose 35 or...
Alzheimer's disease (AD) biomarkers are emerging as critically important for detection and monitoring. Most obtained through invasive, resource-intense procedures. A cognitive marker, intra-individual variability (IICV) may provide an alternative or adjunct marker of risk individuals unable disinclined to undergo lumbar puncture.
Stereotactic body radiation therapy (SBRT) for stage I non-small cell lung cancer (NSCLC) is considered standard of care in the medically inoperable patient population. Multiple methods SBRT delivery exist including fiducial-based tumor tracking, which allows smaller treatment margins and avoidance immobilization devices. We explore long-term clinical outcomes this novel method.In single institutional retrospective review, we detail pathologically confirmed NSCLC. Patients were treated with...
Published data suggests that wedge resection for stage I NSCLC results in improved overall survival compared to stereotactic body radiation therapy (SBRT). We report CyberKnife outcomes high-risk surgical patients with biopsy-proven NSCLC. PET/CT imaging was completed staging. Three-to-five gold fiducial markers were implanted or near tumors serve as targeting references. Gross tumor volumes (GTVs) contoured using lung windows; the margins expanded by 5 mm establish planning treatment volume...
CyberKnife Frameless Image-Guided Stereotactic Radiosurgery with the Synchrony Motion Tracking Module is available for treatment of thoracic malignancies. Gold fiducials are used to mark tumor site and have traditionally been placed through computerized tomographic (CT) guidance. We describe first use video flexible bronchoscopy a modified transbronchial needle aspiration (TBNA) technique placement these fiducials. Fiducials were in 19-gauge 19/21-gauge needle. The fiducial-loaded was then...
Abstract Introduction The potential of intra‐individual cognitive variability (IICV) to predict incident mild impairment (MCI) or Alzheimer's disease (AD) was examined and compared well‐established neuroimaging genetic predictors. Methods IICV estimated using four neuropsychological measures for n = 1324 Disease Neuroimaging Initiative (ADNI) participants who were cognitively healthy diagnosed with MCI at baseline. used time AD, hippocampal volume loss APOE ε4 status via survival analysis....
Local treatment options for patients with in-field non-small cell lung cancer (NSCLC) recurrence following conventionally fractionated external beam radiation therapy (CF-EBRT) are limited. Stereotactic body (SBRT) is a promising modality to achieve reasonable local control, although toxicity remains concern.Patients previously treated high-dose CF-EBRT (≥59.4 Gy, ≤3 Gy/fraction) non-metastatic NSCLC who underwent salvage SBRT localized ultra-central were included in this analysis....
Aerobic Escherichia coli growth at restricted iron concentrations (≤ 1.75 ± 0.04 μM) is characterized by lower biomass yield, higher acetate accumulation and activation of the siderophore iron-acquisition systems. Although homeostasis in E. has been studied intensively, previous studies focused only on understanding regulation import systems iron-requiring enzymes. Here, effect availability energy metabolism investigated. It was established that aerobic cultures growing under limiting...
Abstract Evidence exists that antigen is trapped in lymphoid follicles complexed with antibody (1–6) and antigen-antibody complexes (Ag-Ab) prepared vitro localize these same areas (7). The localization of the depends on presence Fc since Fab fragment do not (8). These studies consider binding Ag-Ab occurs by an receptor present reticular cells. We have previously described a for surface mouse spleen lymphocytes (9–11). This could bind isolated fragments as well complexes. was independent...