A5114375594- Chemotherapy-induced organ toxicity mitigation
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- Antioxidant Activity and Oxidative Stress
- Spinal Cord Injury Research
- Phytochemicals and Antioxidant Activities
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Nigella sativa pharmacological applications
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Trace Elements in Health
- Insect and Pesticide Research
- Cardiac electrophysiology and arrhythmias
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- Birth, Development, and Health
- Renin-Angiotensin System Studies
- Heavy Metal Exposure and Toxicity
- Hormonal Regulation and Hypertension
Fırat University
2009-2024
Cukurova University
2020
Gazi University
2015
Turgut Özal University
2013
Fatih University
2008
Inonu University
1999-2007
Turgut Özal Tıp Merkezi
1999-2004
Elazığ Eğitim ve Araştırma Hastanesi
2003
Oxygen-derived free radicals have been implicated in the pathogenesis of spinal cord neuronal injury after both trauma and ischemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component propolis extract, exhibits antioxidant properties. This experimental study was designed to determine effect CAPE on ischemia-reperfusion rabbits.Forty-one New Zealand white rabbits were used study. The animals undergone aortic occlusion divided into three groups each consisting 11 rabbits:...
The polyphenol curcumin has several pharmacological effects, including antioxidant, anti-inflammatory and anti-cancer features. In this study, we evaluated the effects of in cisplatin-induced nephrotoxicity rats. Male Wistar rats were divided into four groups: (1) control; (2) cisplatin (7 mg/kg body weight, intraperitoneal as a single dose); (3) (100 via gavage, for 10 days); (4) curcumin. cisplatin-treated exhibited kidney injury manifested by increased serum urea creatinine (p < 0.05)....
Abstract Cisplatin-induced nephrotoxicity is related to an increase in oxidative stress the kidney. Lycopene, a carotenoid found tomatoes, potent dietary antioxidant. In present study, we investigated effect of tomato lycopene complex against cisplatin-induced lipid peroxidation and rats. Male Wistar rats (n = 28, 8 wk old, between 200–215 g) were divided into 4 groups: (a) control, (b) (6 mg/kg, daily; consisting 6% lycopene, 1.5% tocopherols, 1% phytoene phytofluene, 0.2% β-carotene), (c)...
Hepatocarcinogenesis is one of the most prevalent and lethal cancers. We studied mechanisms underlying inhibition diethylnitrosamine (DEN)-induced hepatocarcinogenesis by lycopene in rats. was induced an intraperitoneal injection DEN followed promotion with phenobarbital for 24 successive wk. The rats were given (20 mg/kg body weight) 3 times a week orally 4 wk prior to initiation, treatment continued consecutive Lycopene reduced incidence, number, size, volume hepatic nodules. Serum alanine...
Paraoxonase 1 (PON 1) is a high-density lipoprotein (HDL)-associated enzyme with antioxidant function protecting low-density (LDL) from oxidation. PON has two amino acid polymorphisms in coding region; L/M 55 and Q/R 192. These modulate paraoxonase activity of the enzyme. decreases coronary artery disease (CAD). In present study, distribution 192 effect these on activities 1, severity CAD 277 (+) patient 92 (-) subjects were examined. genotypes determined by PCR, RFLP agarose gel...
Noise, one of the main components modern society, has become an important environmental problem. Noise is not only irritating sound, but also a stress factor leading to serious health problems. In this study, we have investigated possible effects rosuvastatin, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, thought antioxidant effect, on noise-induced oxidative in serum rat models. Thirty-two male Wistar albino rats were used. order ease their adaptation, 2 weeks before...
Rotenone, an insecticide of botanical origin, causes toxicity through inhibition complex I the respiratory chain in mitochondria. This study was undertaken to determine whether rotenone-induced liver oxidant injury is prevented by erdosteine, a mucolytic agent showing antioxidant properties. There were four groups Male Wistar Albino rats: group one untreated as control; other treated with erdosteine (50 mg/kg per day, orally), rotenone (2.5 mg/mL once and 1 mL/kg day for 60 days, i.p.) or...
In this study, hair magnesium (Mg), zinc (Zn), copper (Cu), and manganese (Mn) levels, serum Zn Mg levels were measured by atomic absorption spectrophotometer in patients with epilepsy (n = 33) healthy subjects 21), results obtained statistically compared. The mean Cu, Mg, of epileptic significantly lower than the control subjects. There was no significant difference between respect to Mn levels. Mean showed difference, but similar among both groups. When effects anticonvulsant therapy on...
Abstract Omega‐3 essential fatty acids (ω‐3 EFA) contains eicosapentaenoic acid and docosahexaenoic (DHA). DHA is one of the building structures membrane phospholipids brain necessary for continuity neuronal functions. ω‐3 EFA has been suggested to be protective against neuropsychiatric disorders including schizophrenia. This study proposed assess changes in superoxide dismutase (SOD), xanthine oxidase (XO), malondialdehyde (MDA), nitric oxide (NO) hippocampus rats fed with diet (0.4...
Pre-eclampsia (PE) is a leading cause of maternal death worldwide, affecting 3 to 5% all pregnancies. We analyzed the Glu298Asp polymorphism endothelial nitric oxide synthase gene and asymmetric dimethylarginine (ADMA) in 55 Turkish patients with PE without fetal growth retardation (FGR) 54 healthy pregnant women.Restriction fragment length analysis was evaluated by amplification genomic DNA isolated from whole blood followed digestion restriction enzyme Frio. defined according Working...
Abstract Spontaneous leiomyomas of the oviduct are common tumors Japanese quail (Coturnix coturnix japonica) and laying hens. This makes it a good animal model for screening potential agents testing in prevention treatment human myoma uteri. Genistein has been shown to inhibit growth various cancer cells. We investigated effects genistein supplementation on development fibroid oviduct, serum oxidative stress markers [malondialdehyde (MDA), 8-isoprostane, 4-hydroxyalkenal (HAE), 8-hydroxy-2′...
The cholesteryl ester transfer protein (CETP) plays a crucial role in high-density lipoprotein (HDL) metabolism. Genetic variants that alter CETP concentration may cause significant alterations HDL-cholesterol (HDL-C) concentration. In this case-control study, we analyzed the genotype frequencies of Taq1B polymorphisms coronary artery disease patients (CAD; n=210) and controls (n=100). We variant severity CAD, its association with plasma lipids DNA was extracted from 310 undergoing...
The aim of this study was to investigate the effects melatonin on serum asymmetric dimethylarginine (ADMA) levels and expressions vaspin, visfatin, dimethylaminohydrolase (DDAH), signal transducer activator transcription-3 (STAT-3) for evaluation endothelial function inflammation in hypercholesterolemic rats. Rats were divided into 5 groups: (1) control, (2) hypercholesterolaemia, (3) administrated concurrently with cholesterol diet, (4) only last 2 weeks fed (5) atorvastatin administered...
Abstract Objectives Investigation of angiopoietin-like protein-4 (ANGPTL-4) and vascular endothelial growth factor A (VEGF-A) levels as a biochemical marker in gestational hypertension (GH) preeclampsia (PE), which are known to have important roles the maintenance angiogenesis functions. Methods total 90 patients included this case-control study. Group 1 (G1) (n=30)=patients with healthy pregnancy between 37 41 weeks, G2 diagnosed 20 G3 weeks. The sera obtained from were stored at −80 °C...