A5066397483- Fullerene Chemistry and Applications
- Graphene and Nanomaterials Applications
- Curcumin's Biomedical Applications
- Nanoparticles: synthesis and applications
- Chemotherapy-induced organ toxicity mitigation
- Phytochemicals and Antioxidant Activities
- Cancer, Hypoxia, and Metabolism
- Chromium effects and bioremediation
- Nigella sativa pharmacological applications
- Cell death mechanisms and regulation
- Anesthesia and Neurotoxicity Research
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Aldose Reductase and Taurine
- Microtubule and mitosis dynamics
- Antioxidant Activity and Oxidative Stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Heavy Metal Exposure and Toxicity
- S100 Proteins and Annexins
- Essential Oils and Antimicrobial Activity
- Tannin, Tannase and Anticancer Activities
- Boron and Carbon Nanomaterials Research
Bingöl University
2014-2024
Fırat University
2010-2012
Abstract Cisplatin-induced nephrotoxicity is related to an increase in oxidative stress the kidney. Lycopene, a carotenoid found tomatoes, potent dietary antioxidant. In present study, we investigated effect of tomato lycopene complex against cisplatin-induced lipid peroxidation and rats. Male Wistar rats (n = 28, 8 wk old, between 200–215 g) were divided into 4 groups: (a) control, (b) (6 mg/kg, daily; consisting 6% lycopene, 1.5% tocopherols, 1% phytoene phytofluene, 0.2% β-carotene), (c)...
Chromium (Cr) is an essential trace element that has garnered interest for use as a weight loss aid, but its molecular mechanism in obesity not clear. In this study, attempt been made to investigate the effects of chromium histidinate (CrHis) on glucose transporter-2 (GLUT-2), nuclear factor erythroid 2-related 2 (Nrf2), heme oxygenase-1 (HO-1), factor-kappa B (NF-κB p65) and oxidative stress marker 4-hydroxynonenal adducts (HNE) expressions liver rats fed high fat diet (HFD).Male Wistar (n...
The aim of this study was to investigate the antitumor effects quercetin and luteolin combined with 5-Fluorouracil (5-FU) in HT-29 human colorectal cancer cells. Cell viability induced by quercetin, combination these compounds 5-FU were determined MTT assay, also death detection Elisa assay fluorescence microscopy performed apoptotic effects. Hu-VEGF employed determine treatments on angiogenesis. Western blot qRT-PCR analysis p53, Bax, Bcl-2, p38 MAPK, mTOR, PTEN, Akt proteins genes. results...
The aim of this study was to investigate the neuroprotective role ellagic acid (EA) on CCl4-induced brain injury in rats. In study, rats were divided into four groups. Groups: (1) Control group; (2) EA (3) CCl4 (4) + group. tissue, tumor necrosis factor-α (TNF-α), nuclear factor kappa b (NF-kB), cyclooxygenase-2 (COX-2), erythroid related 2 (Nrf-2), cysteine-aspartic protease (caspase-3), VEGF (vascular endothelial growth factor) and B-cell lymphoma-2 (bcl-2) protein expression levels...
Lycopene is a carotenoid found in tomato, watermelon, pink grapefruit, and guava high concentration. Dietary intake of lycopene has been proposed to inversely correlate with the risk cancer. It also reported provide protection against cellular damage caused by reactive oxygen species, which makes it worthwhile study effect on liver rat model.In this study, we report 7,12-dimethylbenz[a]-anthracene (DMBA)-induced expression Bax, Bcl-2, caspases, oxidative stres biomarkers liver.Lycopene was...
A novel nutritional supplement complex (N21 #125) composed of four well-known compounds (chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron) was designed to improve memory function maintain brain health. The present study evaluated the complex's potential mechanism action its role in reducing oxidative stress obese rats fed a high-fat diet (HFD).Male Wistar (n = 40, 8-week-old) were divided into groups. Group I standard diet; II supplemented with N21 } III an HFD; IV...
The objective of this investigation was to investigate the protective effects fullerene C60 nanoparticle against pancreatic damage experimentally induced by 7,12-dimethylbenz [a] anthracene (DMBA) in female rats. Fullerene administered rats 5 times a week oral gavage (o.g) at 1.7 mg/kg bw 7 days after DMBA administration. 60 Wistar albino divided four groups; Groups: (1) Control group: Fed with standard diet; (2) (1.7 bw); (3) (45 (4) + bw) and bw). Lipid peroxidation malondialdehyde (MDA),...
PFKFB3 (6-phosphofructose-2-kinase/fructose-2,6-bisphosphatase 3) is a enzyme involved in glycolysis, the process by which cells convert glucose into energy. known to be overexpressed many types of cancer, including glioblastoma, highly aggressive brain tumour. The epithelial-mesenchymal transition (EMT) biological mechanism linked cancer growth and enhanced invasion metastasis. Inhibition glioblastoma seen as potential therapeutic strategy target EMT inhibit progression. Various small...
Abstract Resistance to chemotherapeutic drugs is a critical problem in cancer therapy, but the underlying mechanism has not been fully elucidated. TP53‐induced glycolysis regulatory phosphatase (TIGAR), an important and apoptosis regulator, plays crucial role cell survival by protecting cells against oxidative stress‐induced apoptosis. In present study, we investigated whether TIGAR involved epithelial‐mesenchymal transition (EMT) doxorubicin (DOX)‐resistant human non‐small lung (NSCLC),...
Background: Cancer is the disease that causes most death after cardiovascular diseases all over world these days. Breast cancer common type of among women and ranks second cancer-related deaths lung cancer. Chemotherapeutics act by killing cells, preventing their spread slowing growth. Recent studies focus on effects chemotherapeutics cells new chemotherapy approaches targeting enzymes catalyze important metabolic reactions in cell. Objective: The aim this study was to investigate...
Herbal compounds are important resources that used in the treatment of many diseases, and inspiring drug design development. Rheum ribes, a perennial native plant, has potentially diverse medicinal effects, including antioxidant, antibacterial anti-tumor activity. The key molecules associated with anticancer activity R. ribes tumor formation still remains unclear. present study was aimed to elucidate antiproliferative effects two purified compounds, emodin aloe-emodin, from ribes. In our...
The present study was designed to evaluate the responsiveness of modulation glial fibrillary acidic protein (GFAP) content and its fragmentation in snake brain as a biomarker local industrial pollution aquatic ecosystems. Despite GFAP being well known cytoskeleton marker astrocytes’ reactivity vertebrates, expression remains insufficiently described. were detected using immunoblot method brain. ROS level determined with dichlorofluorescein diacetate fluorescence. filament (cytoskeleton)...
Moroctocog alpha is a human B-domain deleted recombinant factor VIII (BDDrFVIII), which represents new generation of pure antihemophilic products. We describe here an optimized procedure for polyclonal anti-FVIII-antibody production with the use BDDrFVIII as immunogen. The main immunochemical characteristics produced antibodies and their potential biomedical applications are also reported. Rabbits were immunized emulsion Freund's adjuvant or antigen immobilized in polyacrylamide gel (PAAG)....