A5053992417- Synthesis and biological activity
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Paraoxonase enzyme and polymorphisms
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- Treatment of Major Depression
- Crystallization and Solubility Studies
- Chemical synthesis and pharmacological studies
- Solid-state spectroscopy and crystallography
- Antiplatelet Therapy and Cardiovascular Diseases
- Multicomponent Synthesis of Heterocycles
- Chemical synthesis and alkaloids
- Cancer therapeutics and mechanisms
- Enzyme function and inhibition
- Graphene and Nanomaterials Applications
- Phytochemistry and Biological Activities
- Medical and Biological Ozone Research
- Pomegranate: compositions and health benefits
- Synthesis of heterocyclic compounds
- Sesquiterpenes and Asteraceae Studies
- Gas Sensing Nanomaterials and Sensors
- Fullerene Chemistry and Applications
Fırat University
2019-2025
Inonu University
2015-2021
Hacettepe University
1974-1978
Serotonin (5-HT) and its receptors are involved in various neuropsychiatric disorders, altered serotoninergic neurotransmission interactions between the 5-HT dopamine (DA) systems contribute to pathophysiology of psychotic disorders. Interactions with may elucidation properties modern antipsychotic drugs, whose long-term effects on have not yet been adequately evaluated. Many people society show at least one symptoms disorder, mortality rate is twice as high that a healthy person. In this...
Among many others, coumarin derivatives are known to show human carbonic anhydrase (hCA) inhibitory activity. Since hCA inhibition is one of the underlying mechanisms that account for activities some antiepileptic drugs (AEDs), inhibitors expected have anti-seizure properties. There also several studies reporting compounds with an imidazole and/or benzimidazole moiety which exert these pharmacological In this study, we prepared fifteen novel coumarin-bearing imidazolium and benzimidazolium...
Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter regulation cognition in animals. Inhibition cholinesterases an effective method curb Alzheimer’s disease, progressive fatal neurological disorder. Objective: In this study, 30 new hydrazone derivatives were synthesized. Then we evaluated their anticholinesterase activity compounds. We...
The hexachlorocyclotriphosphaze compound (N3P3Cl6, HCCP) was reacted with excess (E)-(1-(4'-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-ones (2-11) to produce hexakis[(1-(4-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes (CP 2-11). structures of products 2-11) were confirmed using elemental analysis, FT-IR, MS spectral analysis as well 31P, 1H and 13C-APT NMR techniques their thermal properties determined by TGA DSC techniques. HOMO-LUMO energy gap chemical reactivity...
Ellagic acid (EA) has protective effect on testicular damage and this natural compound decreases oxidative damage. The present study aims to examine the preventive of ellagic against carbon tetrachloride (CCl4)-induced tissue in rats. In tissue, tumor necrosis factor-α (TNF-α), Nuclear factor erythroid-2 related 2 (Nrf-2), B-cell lymphoma-2 (Bcl-2), vascular endothelial growth (VEGF), factor-kappa B (NF-κB), cysteine aspartic proteases (caspase-3) protein kinase (Akt) synthesis levels were...
In this study, we aimed to investigate the effect of some coumarin and benzoxazinone derivatives on activity human PON1. Human serum paraoxonase 1 was purified from fresh blood by two-step procedures that are ammonium sulfate precipitation (60–80%) then hydrophobic interaction chromatography (Sepharose 4B, L-tyrosine 1-napthylamine). The enzyme 232-fold with a final specific 27.1 U/mg. vitro effects previously synthesized ionic or (1–21) PON1 were investigated. Compound 14...
Abstract The tendency toward natural herbal products has increased due to the antibiotic resistance developed by microorganisms and severe side effects of antibiotics commonly used in infectious diseases worldwide. Although antimicrobial studies have been conducted with several species Iris genus, this study is first literature be performed persica L. subsp. aqueous methanol extracts. In study, phenolic content I. was determined LC–MS/MS analysis, vitro activity extracts examined, supported...
Monoamine oxidase (MAO) is an enzyme that helps regulate the functions of intracellular amines, as well chemicals such dopamine, serotonin and norepinephrine, in brain its tissues. Active substances are inhibitors monoamine oxidases (MAOs) used treatment anxiety, depression Alzheimer’s disease. Previous studies have shown compounds containing piperazine rings show MAO-A inhibitory activity. Based on these studies, 4 benzothiazole were designed, structures elucidated using spectroscopic...
Purpose: To synthesize a series of new 1-(2-naphthyl)-2-(1H-pyrazol-1-yl)ethanone oxime ester derivatives (5-12) with potential anticancer properties, and to determine their cytotoxic effects in mouse fibroblast human neuroblastoma cell lines.
 Methods: The title compounds were obtained through sodium salt reaction 1-(naphthalene-2-yl)-2- (1H-pyrazol-1-yl)etanone (4) various acyl chlorides. evaluated by MTS colorimetric assay, while physicochemical descriptors calculated using QikProp...
Recent studies have shown that there are many piperazine and oxadiazole derivatives with MAO-A and/or MAO-B inhibitory activity.For this reason in our recent study, a new compound series of oxadiazolepiperazine (4a-e) were designed, synthesized, characterized screened their hMAOs activities.When the silico examined, it was seen pharmacokinetic properties interactions receptor synthesized compounds suitable.Compound 4e, NO2 group on 4-position phenyl ring, found showing significant...
There is an urgent need for a drug to be used against COVID-19, which negatively affects human life worldwide and causes pandemic leading the death of many people. Although some drugs are included in treatment protocols health institutions, there currently no specific COVID-19 or unknown, effective options remain very limited. Since designing novel testing its pharmacological properties may take long years, here we faster virtual study approach our compounds with different chemical...
This study aimed to investigate the effect of propolis on pyruvate kinase (PK) which is a key enzyme in glycolysis and superoxide dismutase (SOD), an antioxidant toxicity induced by DOX different tissues. Using molecular docking, It was looked into how affected enzymes responsible for system. There no application first group (control). The second received 100 mg·kg-1 day gavage needle 7 days, single dose 20 intraperitoneal third group, propolis+DOX fourth group. Two days prior...