A5053583045- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Research and Treatments
- COVID-19 Clinical Research Studies
- Head and Neck Surgical Oncology
- Aquaculture disease management and microbiota
- SARS-CoV-2 and COVID-19 Research
- Oral and Maxillofacial Pathology
- Peptidase Inhibition and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Lung Cancer Treatments and Mutations
- Vaccine Coverage and Hesitancy
- Ear and Head Tumors
- Economic and Financial Impacts of Cancer
- Respiratory Support and Mechanisms
- Cardiac electrophysiology and arrhythmias
- Sepsis Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Ultrasound in Clinical Applications
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Blood Pressure and Hypertension Studies
Instituto do Câncer do Estado de São Paulo
2022-2025
Universidade de São Paulo
2017-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2020-2024
Hospital do Coração
2023
Hospital Israelita Albert Einstein
2023
The University of Texas MD Anderson Cancer Center
2021-2023
Universidade São Judas Tadeu
2020
Harvard University
2014
During the COVID-19 pandemic, creating tools to assess disease severity is one of most important aspects reducing burden on emergency departments. Lung ultrasound has a high accuracy for diagnosis pulmonary diseases; however, there are few prospective studies demonstrating that lung can predict outcomes in patients. We hypothesized score (LUS) at hospital admission could This cohort study conducted from 14 March through 6 May 2020 department (ED) an urban, academic, level I trauma center....
A local increase in angiotensin 2 after inactivation of angiotensin-converting enzyme by severe acute respiratory syndrome coronavirus (SARS-CoV-2) may induce a redox imbalance alveolar epithelium cells, causing apoptosis, increased inflammation and, consequently, impaired gas exchange. We hypothesized that N-acetylcysteine (NAC) administration could restore this homeostasis and suppress unfavorable evolution patients with disease 2019 (COVID-19).This was double-blind, randomized,...
Obesity is a risk factor for the development of asthma. Obese mice exhibit innate airway hyperresponsiveness (AHR), characteristic feature asthma, and IL-17A required AHR in obese mice. The purpose this study was to examine temporal association between onset changes during obesity by high-fat feeding At weaning, C57BL/6J were placed either on mouse chow or diet (HFD) examined 9, 12, 15, 18, 24 weeks later. Airway responsiveness aerosolized methacholine (assessed via forced oscillation...
ObjectiveTo externally validate community-acquired pneumonia (CAP) tools on patients hospitalized with coronavirus disease 2019 (COVID-19) from two distinct countries, and compare their performance recently developed COVID-19 mortality risk stratification tools.MethodsWe evaluated 11 scores in a binational retrospective cohort of São Paulo Barcelona: Pneumonia Severity Index (PSI), CURB, CURB-65, qSOFA, Infectious Disease Society America American Thoracic Minor Criteria, REA-ICU, SCAP,...
The emergence of COVID-19 variants with immune scape and the waning primary vaccine schemes effectiveness have prompted many countries to indicate first second booster doses prevent severe COVID-19. However, current available evidence on dose are mostly limited high-income countries, older adults, mRNA-based vaccination scenarios. We aimed investigate relative (rVE) fourth compared three for outcomes in Brazil; compare rVE a an mRNA adenovirus-based product same settings.
Background: Induction chemotherapy (ICT) is critical for managing locally advanced nasopharyngeal carcinoma (LA-NPC), but real-world data on its efficacy and toxicity are limited.Methods: This retrospective study included LA-NPC patients treated with ICT from 2012 to 2022.We evaluated radiological response rates, overall survival (OS), treatmentrelated toxicities complete (CR) rates.Results: Among 217 patients, 119 met the inclusion criteria were in final analysis.CR rates similar across...
Background The first cases of coronavirus disease (COVID-19) in Brazil were diagnosed February 2020. Our Emergency Department (ED) was designated as a COVID-19 exclusive service. We report our 500 confirmed pneumonia patients. Methods From 14 March to 16 May 2020, we enrolled all patients admitted ED that had diagnosis pneumonia. Infection via nasopharyngeal swabs or tracheal aspirate PCR. outcomes included hospital discharge, invasive mechanical ventilation, and in-hospital death, among...
Adenoid cystic carcinoma (ACC) is a heterogeneous malignancy, and no effective systemic therapy exists for metastatic disease. We previously described two prognostic ACC molecular subtypes with distinct therapeutic vulnerabilities, ACC-I ACC-II. In this study, we explored the tumor microenvironment (TME) using RNA-sequencing spatial biology to identify potential targets.
Adiponectin is an adipose-derived hormone with anti-inflammatory activity. Following subacute ozone exposure (0.3 ppm for 24-72 h), neutrophilic inflammation and IL-6 are augmented in adiponectin-deficient (Adipo(-/-)) mice. The IL-17/granulocyte colony-stimulating factor (G-CSF) axis required this increased neutrophilia. We hypothesized that elevated Adipo(-/-) mice contributes to their responses via effects on IL-17A expression. Therefore, we generated deficient both adiponectin...
Abstract Objectives To evaluate the first‐attempt success rates and complications of endotracheal intubation coronavirus disease 2019 (COVID‐19) patients by emergency physicians. Methods This prospective observational study was conducted from March 24, 2020 through May 28, at department (ED) an urban, academic trauma center. We enrolled consecutively admitted to ED with suspected or confirmed COVID‐19 submitted intubation. No were excluded. The primary outcome success, defined as successful...
We report a second case of methemoglobinemia and non-autoimmune hemolytic anemia after contracting the SARS-CoV-2 infection in absence an identifiable eliciting drug. A 35-year old male without previous known comorbidities was admitted he diagnosed with COVID-19 had large pulmonary involvement. Seven days later, desaturated but any signs respiratory distress. check arterial blood gas revealed normal partial pressure oxygen follow-up tests confirmed diagnosis. Over next few days, hemolysis...
Capacity strain negatively impacts patient outcome, and the effects of surge are a continuous threat during COVID-19 pandemic. Evaluating changes in mortality over time enables evidence-based resource planning, thus improving outcome. Our aim was to describe baseline risk factors associated with among hospitalized patients compare rates time.We conducted retrospective cohort study largest referral hospital for Sao Paulo, Brazil. We investigated hospitalization. Independent variables included...
This study aimed to compare differences in mortality risk factors between admission and follow-up incorporated models.
Recently, a new ECG criterion, the Peguero-Lo Presti (PLP), improved overall accuracy in diagnosis of left ventricular hypertrophy (LVH)-compared to traditional criteria, but with few patients advanced age. We analyzed older age and examined which criteria would have better performance. A total 592 were included (83.1% hypertension, mean 77.5 years) PLP criterion was compared against Cornell voltage (CV), Sokolow-Lyon (SL) Romhilt-Estes (cutoffs 4 5 points, RE4 RE5, respectively) using LVH...
The goal of this paper is to assess the frequency depression symptoms among Brazilian immigrants living in Massachusetts, second largest immigrant population United States, and identify correlates depression. A convenience sample aged 18 or older residing Massachusetts was used. Data were collected from December 2013 March 2014, Consulate General Brazil Boston three religious events, using a structure questionnaire Center for Epidemiological Studies Depression Scale (CES-D). observed 35.3%...
Abstract Background Advanced age is associated with both left bundle branch block (LBBB) and hypertension the usefulness of ECG criteria to detect ventricular hypertrophy (LVH) in patients LBBB still unclear. The diagnostic performance clinical applicability ECG-based LVH defined by stricter unknown. aim this study was compare accuracy utility advanced strict criteria. Methods Retrospective single-center conducted from Jan/2017 Mar/2018. Patients undergoing echocardiogram examinations were...
Abstract Background Overweight and obesity are important risk factors for chronic non-communicable diseases, their prevalence is on the rise worldwide. This study seeks to describe predictors of overweight in Brazilian immigrants living Massachusetts, United States America (USA). Methods Modeled after a survey behavioral disease conducted annually Brazil ( Vigilância de Fatores Risco e Proteção para Doenças Crônicas por Inquérito Telefônico : Vigitel), aged 18+ n = 361) were surveyed between...
5580 Background: The use of poly (ADP-ribose) polymerase inhibitors (PARPi) as maintenance therapy in advanced epithelial ovarian cancer (EOC) patients (pts) has shown to delay progression among with mutated BRCA (mBRCA) or homologous recombination deficiency (HRD), debatable and divergent benefit the subgroup proficiency (HRP). We aimed further clarify efficacy PARPi after first-line chemotherapy (1L CT) HRP EOC. Methods: A systematic literature search PubMed, Embase, Cochrane Library until...