A5043863764- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Lung Cancer Treatments and Mutations
- Cardiac Fibrosis and Remodeling
- Hormonal Regulation and Hypertension
- Lung Cancer Research Studies
- Pituitary Gland Disorders and Treatments
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Adrenal and Paraganglionic Tumors
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Adrenal Hormones and Disorders
- Pluripotent Stem Cells Research
- Neuroscience and Neuropharmacology Research
- Radiopharmaceutical Chemistry and Applications
- Breast Cancer Treatment Studies
- Neuroendocrine Tumor Research Advances
- Extracellular vesicles in disease
Sapienza University of Rome
2013-2025
Società Italiana di Nefrologia
2024
Ospedale Regina Apostolorum
2012-2023
Policlinico Umberto I
2022-2023
Centro di Riferimento Oncologico
1997-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2020
Ospedale San Filippo Neri
2018
Istituto Pasteur
2010-2016
Complejo Hospitalario de Ourense
2015
Ospedale Santa Maria Goretti
1995-2003
Background Bone metastasis represents an increasing clinical problem in advanced gastric cancer (GC) as disease-related survival improves. In literature, few data on the natural history of bone disease GC are available. Patients and Methods Data clinicopathology, skeletal outcomes, skeletal-related events (SREs), bone-directed therapies for 208 deceased patients with evidence were statistically analyzed. Results Median time to was 8 months (CI 95%, 6.125–9.875 months) considering all...
Abstract The ‘cardiosphere’ is a 3D cluster of cardiac progenitor cells recapitulating stem cell niche-like microenvironment with potential for disease and regeneration modelling the failing human myocardium. In this multicellular context, it extremely important to decrypt spatial distribution markers dissecting evolution cellular phenotypes by direct quantification fluorescent signals in confocal microscopy. study, we present fully automated method, named CARE (‘CARdiosphere Evaluation’),...
High-grade aneuploidies of X and Y sex chromosomes (HGAs) are exceedingly rare complex conditions. We aimed to investigate the effect supernumerary (extra-Xs) on clinical, hormonal, metabolic, echocardiographic features patients with HGAs.
Neuroanatomical distribution of FMRFamide-like immunoreactivity was investigated in the brain and olfactory system viviparous skink, Chalcides chalcides. In adult FMRFamide immunoreactive (ir) perikarya were observed diagonal band Broca, medial septal nucleus, accumbens bed nucleus anterior commissure, periventricular hypothalamic lateral forebrain bundle, preoptic, subcommissural, suprachiasmatic areas. This pattern seen both male female brains. Though all major areas showed FMRFamide-ir...
Abstract The effects of mianserin, a tetracyclic antidepressant, on uptake and release [3H]noradrena-line (3H-NA), [3H]dopamine (3H-DA), [3H]-5-hydroxytryptamine(3H-5-HT) [3H]γ-aminobutyric acid (3H-GABA) in synaptosomes from different areas the rat brain were investigated comparative study with tricyclic antidepressant imipramine. Mianserin imipramine inhibitors 3H-NA hypothalamus, but could not increase noradrenergic nerve endings. This behaviour was similar to that (+)-amphetamine. Both...
Abstract Cardiac progenitor cells ( CPC s) isolated as cardiospheres CS and ‐derived CDC are a promising tool for cardiac cell therapy in heart failure patients, having s already been used phase I/II clinical trial. Culture standardization according to Good Manufacturing Practices GMP is mandatory step translation. One of the main issues raised use xenogenic additives e.g . FBS , foetal bovine serum) culture media, which carries risk contamination with infectious viral/prion agents, possible...
Tertiary hyperparathyroidism is characterized by hypercalcemia resulting from autonomous parathyroid hormone production and usually occurs after a prolonged period of secondary hyperparathyroidism. This condition can be complication X-linked hypophosphatemia (XLH), rare genetic disease renal phosphate loss consequent hypophosphatemia. Parathyroidectomy considered the first-line therapy but surgical intervention complicated hungry bone syndrome. A male Caucasian patient presented with XLH,...
Abstract Β-blockers (BB) are a primary treatment for chronic heart disease (CHD), resulting in prognostic and symptomatic benefits. Cardiac cell therapy represents promising regenerative and, autologous therapy, the patients clinical history may correlate with biology of resident progenitors quality final product. This study aimed at uncovering correlations between records biopsy-donor CHD undergoing cardiac surgery corresponding yield phenotype cardiospheres (CSs) CS-derived cells (CDCs),...
Registry data show that Cushing's syndrome (CS) and adrenal insufficiency (AI) increase mortality rates associated with infectious diseases. Little information is available on susceptibility to milder forms of infections, especially those not requiring hospitalization. This study aimed investigate diseases in patients glucocorticoid disorders through the development a specific tool.We developed administered InfeCtions pAtients endocRinOpathies (ICARO) questionnaire, addressing events over...
Autologous cardiac progenitor cells (CPCs) isolated as cardiospheres (CSps) represent a promising candidate for regenerative therapy. A better understanding of the origin and mechanisms underlying human CSps formation maturation is undoubtedly required to enhance their cardiomyogenic potential. Epithelial-to-mesenchymal transition (EMT) key morphogenetic process that implicated in acquisition stem cell-like properties different adult tissues, it activated epicardium after ischemic injury...
Cardiac progenitor cells (CPCs) represent a powerful tool in cardiac regenerative medicine. Pre-clinical studies suggest that most of the beneficial effects promoted by injected are due to their paracrine activity exerted on endogenous and tissue. Exosomes candidate mediators this effects. According potential, many researchers have focused characterizing exosomes derived from specific cell types, but, up until now, only few analyzed possible vitro bovine serum-derived proliferation or...
Abstract Basic and translational research on lung biology has discovered multiple progenitor cell types, specialized or facultative, responsible for turnover, renewal, repair. Isolation of populations resident cells (LPCs) been described by protocols, some have successfully applied to healthy human tissue. We aimed at understanding how different culture conditions may affect, in vitro, the phenotype LPCs create an ideal niche-like microenvironment. The influence substrates (i.e.,...
Cardiac adverse remodeling is characterized by biological changes that affect the composition and architecture of extracellular matrix (ECM). The consequently disrupted signaling can interfere with balance between cardiogenic pro-fibrotic phenotype resident cardiac stromal primitive cells (CPCs). latter are important players in homeostasis be exploited as therapeutic regenerative medicine. Our aim was to compare effects human decellularized native ECM from normal (dECM-NH) or failing hearts...
PURPOSE The usefulness of extensive and repetitive surgery for patients with ovarian cancer still remains unproven (at least some conditions). We planned an accurate prospective test the hypothesis that advanced-stage disease, after they had reached a clinical complete remission (CR), may benefit from surgical second look (SSL). PATIENTS AND METHODS One hundred two in CR (as assessed by findings, markers, visualization computed tomographic [CT] scan laparoscopy), initial debulking first-line...