A5043077427- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Clusterin in disease pathology
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- S100 Proteins and Annexins
- BRCA gene mutations in cancer
- Head and Neck Anomalies
- Hippo pathway signaling and YAP/TAZ
- Renal cell carcinoma treatment
Vanderbilt University Medical Center
2022-2025
Vanderbilt University
2024
Clear cell renal carcinoma (ccRCC) is characterized by dysregulated hypoxia signaling and a tumor microenvironment (TME) highly enriched in myeloid lymphoid cells. Loss of the von Hippel Lindau (VHL) gene critical early event ccRCC pathogenesis promotes stabilization HIF. Whether VHL loss cancer cells affects immune TME remains unclear. Using Vhl WT Vhl-KO vivo murine kidney Renca models, we found that tumors were more infiltrated Tumor-associated macrophages (TAMs) from Vhl-deficient...
Thyroid cancer progression from curable well-differentiated thyroid carcinoma to highly lethal anaplastic is distinguished by tumor cell de-differentiation and recruitment of a robust stromal infiltrate. Combining an integrated single-cell sequencing atlas with spatial transcriptomics bulk RNA-sequencing, we define subpopulations tumor-stromal cross-talk occurring across the histologic mutational spectrum cancer. We identify distinct inflammatory myofibroblastic cancer-associated fibroblast...
Abstract Tenascin-C (TNC) is a secreted extracellular matrix protein that highly expressed during embryonic development and re-expressed wound healing, inflammation, neoplasia. Studies in developmental models suggest TNC may regulate the Wnt signaling pathway. Our lab has shown high levels of expression anaplastic thyroid cancer (ATC), lethal with an abysmal ∼3-5 month median survival. Here, we investigated role facilitating ligand-dependent cancer. We utilized bulk RNA-sequencing from three...
Genomic and transcriptomic analysis has furthered our understanding of many tumors. Yet, thyroid cancer management is largely guided by staging histology, with few molecular prognostic treatment biomarkers. Here, we utilize a large cohort 251 patients 312 samples from two tertiary medical centers perform DNA/RNA sequencing, spatial transcriptomics, multiplex immunofluorescence to identify biomarkers aggressive malignancy. We high-risk mutations discover unique signature disease, the...
Abstract Background Anaplastic thyroid carcinoma (ATC) is a highly aggressive malignancy that has consistently shown Wnt/β-catenin (canonical) signaling activation in various study populations. There are currently no targetable treatments for BRAF -wildtype ATC and lack of effective treatment V600E ATC. Our aim to identify whether Wnt inhibitors could be potential therapeutic agents patients with limited options. Methods In this Institutional Review Board-approved study, we utilize cohort 32...
Abstract Tumor-associated macrophages (TAM) play an important role in supporting tumor growth and suppressing antitumor immune responses, TAM infiltration has been associated with poor patient prognosis various cancers. TAMs can be classified as pro-inflammatory, M1-like, or anti-inflammatory, M2-like. While multiple factors within the microenvironment affect recruitment, polarization, functions of TAMs, accumulating evidence suggests that Wnt signaling represents important, targetable...
Abstract Tenascin-C (TNC) is a secreted extracellular matrix protein that highly expressed during embryonic development and re-expressed wound healing, inflammation, neoplasia. Studies in developmental models suggest TNC may regulate the Wnt signaling pathway. Our lab has shown high levels of expression anaplastic thyroid cancer (ATC), lethal with an abysmal ∼3-5 month median survival. Here, we investigated role facilitating ligand-dependent cancer. We utilized bulk RNA-sequencing from three...