A5023328967- Adenosine and Purinergic Signaling
- Pharmacological Receptor Mechanisms and Effects
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Thyroid Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- CAR-T cell therapy research
- Cutaneous Melanoma Detection and Management
- Head and Neck Cancer Studies
- Receptor Mechanisms and Signaling
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Salivary Gland Tumors Diagnosis and Treatment
- Artificial Intelligence in Healthcare and Education
- Thyroid and Parathyroid Surgery
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
- Bioinformatics and Genomic Networks
- Endoplasmic Reticulum Stress and Disease
- Intraperitoneal and Appendiceal Malignancies
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Ginkgo biloba and Cashew Applications
Vanderbilt University Medical Center
2023-2025
Vanderbilt University
2024
Vanderbilt-Ingram Cancer Center
2024
Duke Medical Center
2016-2023
Duke Cancer Institute
2021-2023
Duke University
2018-2023
Cancer Institute (WIA)
2022
University of North Carolina at Chapel Hill
2019-2020
Asan Medical Center
2018
Baylor College of Medicine
2013-2014
Abstract Background: Natural language processing models such as ChatGPT can generate text-based content and are poised to become a major information source in medicine beyond. The accuracy completeness of for medical queries is not known. Methods: Thirty-three physicians across 17 specialties generated 284 questions that they subjectively classified easy, medium, or hard with either binary (yes/no) descriptive answers. then graded ChatGPT-generated answers these (6-point Likert scale; range...
Importance Natural language processing tools, such as ChatGPT (generative pretrained transformer, hereafter referred to chatbot), have the potential radically enhance accessibility of medical information for health professionals and patients. Assessing safety efficacy these tools in answering physician-generated questions is critical determining their suitability clinical settings, facilitating complex decision-making, optimizing care efficiency. Objective To assess accuracy...
In a pilot study involving patients with cutaneous squamous-cell carcinoma, high percentage of had pathological complete response the use two doses neoadjuvant cemiplimab before surgery. Data from phase 2 are needed to confirm these findings.
Abstract Purpose: To evaluate AZD4635, an adenosine A2A receptor antagonist, as monotherapy or in combination with durvalumab patients advanced solid tumors. Patients and Methods: In phase Ia (dose escalation), had relapsed/refractory tumors; Ib expansion), checkpoint inhibitor–naïve metastatic castration-resistant prostate cancer (mCRPC) colorectal carcinoma, non–small cell lung prior anti–PD-1/PD-L1 exposure, other tumors (checkpoint-naïve exposure). received AZD4635 (75–200 mg once daily...
Few antiviral therapies have been studied in patients with coronavirus disease 2019 (COVID-19) and kidney impairment. Herein, the efficacy, safety, pharmacokinetics of remdesivir, its metabolites, sulfobutylether-β-cyclodextrin excipient were evaluated hospitalized COVID-19 severe In REDPINE, a phase 3, randomized, double-blind, placebo-controlled study, participants aged ≥12 years for pneumonia acute injury, chronic disease, or failure randomized 2:1 to receive intravenous remdesivir (200...
Thyroid cancer progression from curable well-differentiated thyroid carcinoma to highly lethal anaplastic is distinguished by tumor cell de-differentiation and recruitment of a robust stromal infiltrate. Combining an integrated single-cell sequencing atlas with spatial transcriptomics bulk RNA-sequencing, we define subpopulations tumor-stromal cross-talk occurring across the histologic mutational spectrum cancer. We identify distinct inflammatory myofibroblastic cancer-associated fibroblast...
Abstract Tenascin-C (TNC) is a secreted extracellular matrix protein that highly expressed during embryonic development and re-expressed wound healing, inflammation, neoplasia. Studies in developmental models suggest TNC may regulate the Wnt signaling pathway. Our lab has shown high levels of expression anaplastic thyroid cancer (ATC), lethal with an abysmal ∼3-5 month median survival. Here, we investigated role facilitating ligand-dependent cancer. We utilized bulk RNA-sequencing from three...
<title>Abstract</title> Background Antibody-based therapies (such as anti-EGFR and anti-PD1/L1 agents) have altered the landscape of cancer treatment to improve patient outcomes in formerly unresponsive tumor types. However, this robust response is not ubiquitous for all patients or subtypes. Head neck squamous cell carcinoma continues reduced many populations regardless target expression (e.g. EGFR PDL1). The role microenvironmental proteins, such fibroblast activation protein (FAP), may...
Genomic and transcriptomic analysis has furthered our understanding of many tumors. Yet, thyroid cancer management is largely guided by staging histology, with few molecular prognostic treatment biomarkers. Here, we utilize a large cohort 251 patients 312 samples from two tertiary medical centers perform DNA/RNA sequencing, spatial transcriptomics, multiplex immunofluorescence to identify biomarkers aggressive malignancy. We high-risk mutations discover unique signature disease, the...
5518 Background: AZD4635 inhibits adenosine 2a receptor (A2aR) signaling and improves immune activation anti-tumor activity in preclinical models. This phase I study assessed the safety, pharmacokinetics, pharmacodynamics efficacy of monotherapy (mono) combination (combo) with durvalumab (durva) patients (pts) refractory solid tumors. Here we present data for checkpoint-naïve pts metastatic castrate-resistant prostate cancer (mCRPC). Methods: Pts mCRPC received mono (75 mg or 100 QD oral...
Abstract Tenascin-C (TNC) is a secreted extracellular matrix protein that highly expressed during embryonic development and re-expressed wound healing, inflammation, neoplasia. Studies in developmental models suggest TNC may regulate the Wnt signaling pathway. Our lab has shown high levels of expression anaplastic thyroid cancer (ATC), lethal with an abysmal ∼3-5 month median survival. Here, we investigated role facilitating ligand-dependent cancer. We utilized bulk RNA-sequencing from three...
Background The optimal timing for initiating multi-kinase inhibitors (MKIs) in patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC) remains unclear. Thus, we evaluated the real-world practice patterns and outcomes asymptomatic progressive RAI-R DTC (≥1 lesion ≥1 cm diameter) USA (US population) outside (non-US population). Methods In this prospective, non-interventional, open-label study, eligible were chosen by treating physicians to receive MKI therapy...
2604 Background: XmAb23104 is a bispecific antibody targeting T cells that simultaneously express PD-1, an immune checkpoint, and ICOS, costimulatory molecule expressed after cell activation. DUET-3 Phase 1, first-in-human, dose-escalation expansion study in subjects with advanced solid tumors, designed to assess safety, tolerability identify the maximum tolerated dose (MTD) of XmAb23104. Secondary objectives are pharmacokinetics (PK), immunogenicity, preliminary anti-tumor activity. We...
TPS6092 Background: Approximately 25% of patients (pts) with NPC develop RM disease, which has a poor prognosis (median overall survival [mOS]: 12–16 mo), despite standard treatments radiation and/or chemotherapy. is an EBV-associated cancer in programmed cell death ligand 1 (PD-L1) expression upregulated upon EBV activation. Pembro showed antitumor activity phase 1b study pts RM-NPC (objective response rate [ORR]: 26%; mOS: 16.5 mo) (Hsu, J Clin Oncol 2017;35:4050-56). Targeting EBV+...
11079 Background: Phase 3 randomized clinical trials (RCTs) inform the standard of care in cancer treatment yet have a mixed track record success. In this study, we sought to 1) determine overall success rate phase RCTs; 2) assess whether authorship patterns differ between successful (positive) and unsuccessful (negative) trials; 3) explore if individual authors distinct records Methods: The HemOnc knowledgebase (KB) was queried for initial publications RCTs systemic anticancer therapy;...