Tito Palmela Leitão

ORCID: 0000-0002-0075-6196
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About
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Research Areas
  • Prostate Cancer Diagnosis and Treatment
  • Renal and related cancers
  • Renal cell carcinoma treatment
  • Urologic and reproductive health conditions
  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Sarcoma Diagnosis and Treatment
  • Urological Disorders and Treatments
  • Urinary Bladder and Prostate Research
  • Prostate Cancer Treatment and Research
  • Ureteral procedures and complications
  • 3D Printing in Biomedical Research
  • Anorectal Disease Treatments and Outcomes
  • Bladder and Urothelial Cancer Treatments
  • Diversity and Career in Medicine
  • Pelvic floor disorders treatments
  • Surgical Simulation and Training
  • Adrenal and Paraganglionic Tumors
  • Cancer, Lipids, and Metabolism
  • Endometriosis Research and Treatment
  • Clinical practice guidelines implementation
  • Multiple and Secondary Primary Cancers
  • Pancreatic and Hepatic Oncology Research
  • Medical Imaging and Pathology Studies
  • Gynecological conditions and treatments

University of Lisbon
2016-2024

Hospital de Santa Maria
2013-2024

Administração Regional de Saúde de Lisboa e Vale do Tejo
2024

Centro Hospitalar Lisboa Norte
2012-2023

Instituto de Medicina Molecular João Lobo Antunes
2021

Federico Santa María Technical University
2019

Hospital da Luz
2013

Centro Hospitalar do Porto
2011

Renal cell carcinoma (RCC) presents as metastatic disease in one third of cases. Research on circulating tumor cells (CTCs) and liquid biopsies is improving the understanding RCC biology metastases formation. However, a standardized, sensitive, specific, cost-effective CTC detection technique lacking. The use platforms solely relying epithelial markers inappropriate due to frequent epithelial-mesenchymal transition that CTCs undergo. This study aimed test clinically validate RUBYchip™,...

10.3390/ijms24098404 article EN International Journal of Molecular Sciences 2023-05-07

Renal cell carcinoma (RCC) often develops a tumor thrombus extending into the inferior vena cava (IVC). Radical nephrectomy with IVC thrombectomy is standard treatment, although prognostic factors are yet to be properly established.

10.4103/ua.ua_113_23 article EN cc-by-nc-sa Urology Annals 2024-10-01

To assess the safety and oncological functional efficacy of a prospective series extraperitoneal laparoscopic radical prostatectomy (ELRP).This study included 171 consecutive patients (mean age 62.9 years, SD 6.5) who underwent ELRP by one surgeon between January 2008 December 2009. The variables analysed were operative duration, blood loss, conversion rate, complications, hospital stay, duration catheterisation, results. We also assessed rates continence erectile function.There no...

10.1016/j.aju.2012.09.001 article EN cc-by-nc-nd Arab Journal of Urology 2012-10-27

Transurethral resection of the prostate (TURP) remains one goldstandard surgical treatments for benign prostatic hyperplasia/lower urinary tract symptoms. The usefulness a complete adenoma is questionable, with studies reporting no impact amount resected tissue on outcomes, irrespective volume. aim this study was to assess whether in less obstructed patients extensive TURP may be considered.Retrospective analysis 185 men undergoing university hospital. Retrieved data included pre-operative...

10.4081/aiua.2022.2.169 article EN cc-by-nc Archivio Italiano di Urologia e Andrologia 2022-06-29

The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.

10.20517/2394-4722.2021.88 article EN Journal of Cancer Metastasis and Treatment 2021-01-01

Objective To present six cases of ureteral endometriosis with renal loss managed by a multidisciplinary minimally invasive approach. Introduction Severe can potentially lead to urinary tract obstruction and silent function. Nephrectomy should be considered may performed Material methods Retrospective observational study patients deep involvement consequently function who underwent laparoscopic nephrectomy between April 2009 2016 in tertiary care university hospital. The clinical...

10.5301/je.5000260 article EN Journal of Endometriosis and Pelvic Pain Disorders 2016-10-01

Binding of NK cell inhibitory receptors to MHC class I (MHC-I) confers increased responsiveness cells by a process known as licensing/education. Reduced MHC-I expression or lack for results in diminished responsiveness. In this study, we evaluated the effect human and mouse licensing on early stages natural cytotoxicity. Unlicensed did not form many stable conjugates with target cells. The reduction conjugation was attributed altered β<sub>2</sub> integrin LFA-1 properties but instead due...

10.1136/bmj.f3513 article EN BMJ 2013-06-05

<title>Abstract</title> Introduction: Circulating tumor cells (CTCs) may be the missing renal cell carcinoma (RCC) biomarker. Material and Methods: Randomized controlled trial comparing CTC circulating mesenchymal (CMC) release in no-touch (NT) vs. conventional (C) laparoscopic RN. Blood samples were collected at operation room arrival (S0), specimen extraction (S1), postoperative D1, D30. CTCs isolated analyzed using RUBYchip™. Results: 34 patients randomized from September 2021 to April...

10.21203/rs.3.rs-3376872/v1 preprint EN cc-by Research Square (Research Square) 2023-10-28

Pheochromocytomas with vena cava thrombus are extremely rare, only a few cases reported in the literature. Radical nephrectomy adrenalectomy and inferior (IVC) thrombectomy is treatment of choice. However, it challenging procedure its surgical approach yet to be standardized. We present case 49-year-old male incidentally diagnosed pheochromocytoma aggressive local invasion level 1 thrombus. A laparoscopic right radical adrenalectomy, IVC cavorraphy. detailed revision technique performed...

10.24915/aup.37.1-2.162 article EN Acta Urológica Portuguesa 2022-01-26
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