A5015662869- Pancreatic function and diabetes
- Electrostatics and Colloid Interactions
- Advanced Polymer Synthesis and Characterization
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Coagulation and Flocculation Studies
- Tissue Engineering and Regenerative Medicine
- Surfactants and Colloidal Systems
- Conducting polymers and applications
- Mesenchymal stem cell research
- Advanced Drug Delivery Systems
- Microfluidic and Capillary Electrophoresis Applications
- Ionic liquids properties and applications
- Protein purification and stability
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Minerals Flotation and Separation Techniques
- Analytical Chemistry and Sensors
- Analytical Chemistry and Chromatography
- Dendrimers and Hyperbranched Polymers
- Liver physiology and pathology
- RNA Interference and Gene Delivery
- Diabetes and associated disorders
- Photopolymerization techniques and applications
- Fuel Cells and Related Materials
École Polytechnique Fédérale de Lausanne
2009-2020
University Hospital of Geneva
2016
Université de Picardie Jules Verne
2013
Merck Serono (Switzerland)
2010
Bioengineering (Switzerland)
2010
A. N. Nesmeyanov Institute of Organoelement Compounds
2009
Max Planck Institute for Polymer Research
2005
University of Leeds
2005
Institute of Nuclear Physics, Polish Academy of Sciences
2004
Institute of Physics
2004
With the discovery of important biological roles carbon monoxide (CO), use this gas as a therapeutic agent has attracted attention. However, medical application been hampered by complexity administration method. To overcome problem, several transition-metal carbonyl complexes, such Ru(CO)3Cl(glycinate), [Ru(CO)3Cl2]2, and Fe(η4-2-pyrone)(CO)3, have used CO-releasing molecules both in vitro vivo. We sought to develop micellar forms metal complexes that would display slowed diffusion tissues...
Mesenchymal stem cell (MSC) transplantation was shown to be effective for the treatment of liver fibrosis, but mechanisms action are not yet fully understood. We transplanted encapsulated human MSCs in two mouse models fibrosis determine behind protective effect.Human bone marrow-derived were microencapsulated novel alginate-polyethylene glycol microspheres. In vitro, we analyzed effect MSC-conditioned medium on activation hepatic stellate cells and viability, proliferation, cytokine...
Three novel ionic monomers having highly delocalized anions and electrochemically stable mobile cations, namely, 1-butyl-1-methylpyrrolidinium 1-[3-(methacryloyloxy)propylsulfonyl]-1-(trifluoromethane-sulfonyl)imide, 1,1-dicyano-1-[(3-(methacryloyloxy)propylsulfonyl)]methanide 1-cyano-1-[(3-(methacryloyloxy)propylsulfonyl)]imide were synthesized characterized. The structure of these was designed to be a mimic the most conductive bis(trifluoromethylsulfonyl)imide, tricyanomethanide...
Pegylation using heterotelechelic poly(ethylene glycol) (PEG) offers many possibilities to create high-performance molecules and materials. A versatile route is proposed synthesize heterobifunctional PEG containing diverse combinations of azide, amine, thioacetate, thiol, pyridyl disulfide, as well activated hydroxyl end groups. Asymmetric activation one group enables the heterobifunctionalization while applying selective monotosylation linear, symmetrical a key step. The azide function...
The achievement of high ionic conductivity in new "polymeric liquids" (PILs) is great interest as it refers to the solid state electrolytes and their applications electrochemistry. Four monomers, including two ones, namely N-[(2-methacryloyloxy)-propyl]-N-methylpyrrolidinium bis(trifluoromethylsulfonyl)amide (M1), 1-[2-(methacryloyloxy)propyl]-3-methylimidazolium (M2), N-methyl-N-ethylpyrrolidinium(3-sulfopropyl) methacrylate (M3), 1-methyl-3-ethylimidazolium(3-sulfopropyl) (M4), were...
Hydrophilic nanocarriers formed by electrostatic interaction of chitosan with oppositely charged macromolecules have a high potential as vectors in biomedical and pharmaceutical applications. However, comprehensive information about the fate such nanomaterials biological environment is lacking. We used from both animal fungal sources to form well-characterized chitosan-pentasodium triphosphate (TPP)//alginate nanogels suitable for comparative studies. Upon exposure human colon cancer cells...
Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets Langerhans. We aimed to examine the interactions between human MSC Langerhans that influence islets.Human (or pseudoislets, obtained after digestion reaggregation islet cells) were cocultured with or without cellular contact glucose-stimulated insulin secretion assays performed assess cell function. The expression several adhesion molecules, notably ICAM-1 N-cadherin on MSC, was investigated by qPCR. role...
A one-step extrusion process under physiological conditions yielded calcium alginate-poly(ethylene glycol) hybrid microspheres (Alg-PEG-M), for which the physical properties were adjustable by macromolecular characteristics of components, their concentration as well conditions. solution containing a mixture sodium alginate (Naalg) and multiarm vinyl sulfone-terminated PEG (PEG-VS) was extruded into receiving bath providing ions thiol cross-linker. Covalent cross-linking PEG-VS occurred in...
Two novel types of hydrogel microspheres (MS) are presented. First, one-component (1-comMS) were produced from sodium alginate (Na-alg) equipped with thiol-functionalized hydroxyl groups. The functionalization pathway included the conversion Na-alg into tetrabutylammonium alginate, insertion new carboxyl groups, grafting α-amine-ω-thiol poly(ethylene glycol), and restoration salt. This modification conserves all original groups allows for covalent disulfide bond formation in addition to...
Comprehensive counterion activity studies have revealed clear influence of the polyelectrolyte concentration and chain length on polyion−counterion interaction, neither which is evident from existing theoretical models. The coefficient (fa) increases below overlap c* as calculated Odijk's scaling approach. At dilutions where Debye (lD) exceeds contour (L), this increase more pronounced. It concluded that these changes in ionic interactions are primarily responsible for strong equivalent...
The progress of medical therapies, which rely on the transplantation microencapsulated living cells, depends quality encapsulating material. Such material has to be biocompatible, and microencapsulation process must simple not harm cells. Alginate-poly(ethylene glycol) hybrid microspheres (alg-PEG-M) were produced by combining ionotropic gelation sodium alginate (Na-alg) using calcium ions with covalent crosslinking vinyl sulfone-terminated multi-arm poly(ethylene (PEG-VS). In a one-step...
A general description of the electrolytic conductivity behavior highly charged strong polyelectrolytes in dilute and semidilute aqueous solutions is presented. For first time this model considers influences molar mass, charge density (for distances less than Bjerrum length), polyelectrolyte concentration, ionic strength adjusted by both concentration (cp monomol L-1) added simple salt (cs mol L-1). Above overlap (c*) mass influence weak. Below equivalent (Λ) increases strongly with...
This report describes the aqueous solution self-assembly of a series polystyrene(m)-b-poly(L-lysine)n block copolymers (m = 8-10; n 10-70). The polymers are prepared by ring-opening polymerization epsilon-benzyloxycarbonyl-L-lysine N-carboxyanhydride using amine terminated polystyrene macroinitiators, followed removal benzyloxycarbonyl side chain protecting groups. critical micelle concentration determined pyrene probe technique shows parabolic dependence on peptide length exhibiting maximum...
With higher nutrient and oxygen supply close contact to blood, the portal vein is a possible alternative peritoneal cavity for transplantation of encapsulated cells. Data regarding intraportal biocompatibility microcapsules are lacking. Microcapsules were built from five alginate types differing in their molar mass mannuronic/guluronic acid ratios by complex formation with divalent cations (barium or calcium) mixtures polycations. They injected rats, cellular fibrotic pericapsular...