A5014147709- Nanoplatforms for cancer theranostics
- Sulfur Compounds in Biology
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Advanced Polymer Synthesis and Characterization
- Graphene and Nanomaterials Applications
- Luminescence and Fluorescent Materials
- Supramolecular Self-Assembly in Materials
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Heme Oxygenase-1 and Carbon Monoxide
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrospun Nanofibers in Biomedical Applications
- Covalent Organic Framework Applications
- Biopolymer Synthesis and Applications
- Free Radicals and Antioxidants
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Ion-surface interactions and analysis
- Angiogenesis and VEGF in Cancer
- Obstructive Sleep Apnea Research
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Drug Delivery Systems
- Fibroblast Growth Factor Research
Pennsylvania State University
2021-2024
Kansas State University
2017-2021
Osaka University
2013-2018
Suita Municipal Hospital
2015
École Polytechnique Fédérale de Lausanne
2010-2013
Tokyo Medical and Dental University
2005-2009
Waseda University
2003-2004
With the discovery of important biological roles carbon monoxide (CO), use this gas as a therapeutic agent has attracted attention. However, medical application been hampered by complexity administration method. To overcome problem, several transition-metal carbonyl complexes, such Ru(CO)3Cl(glycinate), [Ru(CO)3Cl2]2, and Fe(η4-2-pyrone)(CO)3, have used CO-releasing molecules both in vitro vivo. We sought to develop micellar forms metal complexes that would display slowed diffusion tissues...
Previously we reported emulsion polymerization of propylene sulfide with Pluronic F127 as an emulsifier, yielding nanoparticles (NPs) in the 25 nm size range. Immunologically functional NPs were prepared by adding antigen−Pluronic conjugate to mixture (Reddy, S. T., et al. (2007) Nat. Biotechnol. 25, 1159). We sought a more flexible scheme for conjugation antigens and other biomolecules NP surfaces that would allow milder reaction conditions than achievable during step. Here, present...
Abstract Bone regeneration for the defects in revision surgery of joint replacement is an increasingly important issue. To repair bone defects, cell activation by growth factors using synthetic resorbable scaffold a useful and safe option. We examine efficiency nanogel‐crosslinking hydrogel as novel BMP to stimulate osteoblasts induce formation. Cholesterol‐bearing pullulan (CHPA/Hydrogel) was used deliver BMP. The CHPA pellets were implanted vivo. Single implantation CHPA/hydrogel...
Hydrogen sulfide (H2S) is a gaseous signaling molecule that has several important biological functions in the human body. Because of difficulties handling H2S gas, small organic compounds release under physiological conditions have been developed. The observed bioactivities these donors generally directly correlated with their properties. However, apart from release, also exert effects by direct interaction intracellular components within cytoplasm after passive diffusion across cellular...
Abstract Angiogenesis is regulated in coordinated fashion by chemical and mechanical cues acting on endothelial cells (ECs). However, the mechanobiological mechanisms of angiogenesis remain unknown. Herein, we demonstrate a crucial role blood flow-driven intraluminal pressure (IP) regulating wound angiogenesis. During angiogenesis, IP loading inhibits elongation injured vessels located at sites upstream from flow, while downstream actively elongate. In vessels, F-BAR proteins, TOCA1 CIP4,...
Abstract Recovery of bone loss is one the active research issues in medicine due to need for efficient measures gain. We examined here a novel drug delivery system using nanogel cholesterol‐bearing pullulan (CHP) combination with prostaglandin E 2 (PGE ). PGE or /CHP, vehicle (saline containing 0.06% ethanol and 0.02% Tween 80) CHP were injected on calvariae mice once every day 5 days per week 4 weeks. Low dosage (0.6 µg) alone did not induce new formation this system. In contrast, µg)/CHP...
Carbon monoxide (CO) is an essential gaseous signaling molecule in the human body. Toward controlled delivery of CO to target tissues or cells, nanomaterial-based donors have attracted growing attention. Here, we present CO-releasing polymeric nanoparticles (CONPs) prepared by simple mixing phenylboronic acid-containing framboidal with catechol-bearing CO-donor Ru(CO)3Cl(L-DOPA) via acid-catechol complexation. The CONPs release response cysteine and suppress production pro-inflammatory...
Curcumin (Cur) has a wide range of bioactivities that show potential for the treatment cancer as well chronic diseases associated with inflammation and aging. However, therapeutic efficacy Cur been hampered by its rapid degradation under physiological conditions low aqueous solubility. To address these problems, we prepared Cur-loaded polymeric nanoparticles (CNPs), in which was complexed phenylboronic acid-containing framboidal (NPs), simple mixing NPs an solution. CNPs showed improved...
H<sub>2</sub>S-releasing polymeric micelles promote angiogenesis.
Phenylboronic acid-containing nanomaterials have found applications in various fields including biomedical engineering due to their unique stimuli-responsive characteristics. Contrary the many reports on spherical nanoparticles, we are interested nanostructures with different morphology which could potentially exhibit additional morphology-related effects. Here, phenylboronic nanoparticles (PBANPs) size range of 80–250 nm diameter were synthesized via aqueous dispersion polymerization...
Abstract Per/polysulfide species that are generated from endogenously produced hydrogen sulfide have critical regulatory roles in a wide range of cellular processes. However, the lack delivery systems enable controlled and sustained release these unstable biological hinders advancement biology research, as well translation knowledge to therapeutic applications. Here, novel approach is developed generate per/polysulfide cells by combining an H 2 S donor manganese porphyrin‐containing...
Colloidal drug and prodrug conjugates have unique targeting characteristics for tumor vasculature from the blood lymphatics draining a tissue injection site. Tioguanine tioguanine-generating prodrugs been investigated as anticancer immunosuppressive agents, including use in cancer immunotherapy. Recently we developed block copolymers of poly(ethylene glycol)-bl-poly(propylene sulfide) that self-assemble aqueous solutions to form micellar structures. Since polymers carry free terminal thiol...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat acute pain, fever, and inflammation being explored in a new indication cancer. Side effects associated with long-term use of NSAIDs such as gastrointestinal damage elevated risk stroke, however, can limit their exploration indications. Here we report facile method prepare well-defined amphiphilic diblock copolymer NSAID prodrugs by direct reversible addition-fragmentation transfer (RAFT) polymerization the acrylamide...
Hydrogen sulfide-releasing polymeric micelles enhanced pro-inflammatory responses induced by gardiquimod, a toll-like receptor 7 ligand, showing potential in immunotherapy and vaccine development.
Oxidation-sensitive drug delivery systems (DDSs) have attracted attention due to the potential improve efficacy and safety of chemotherapeutics. These are designed release payload in response oxidative stress conditions, which associated with many types cancer. Despite extensive research on development oxidation-sensitive DDS, lack selectivity toward cancer cells over healthy remains a challenge. Here, we report design characterization polymeric micelles containing thioether groups varying...
Abstract Hydrogen sulfide (H 2 S) is a gaseous signaling molecule in the human body and has attracted attention cancer therapy due to its regulatory roles cell proliferation migration. Accumulating evidence suggests that continuous delivery of H S cells for extended periods time suppresses progression. However, one major challenge therapeutic applications controlled delivery. To solve this problem, polymeric micelles are developed containing donating‐anethole dithiolethione (ADT) groups,...
Starting from 20 amine-functionalized metal–organic framework (MOF) candidates, we have downselected a few for CO2 adsorption applications. We developed ReaxFF force fields these MOFs and applied both Grand canonical Monte Carlo calculation metadynamics simulations to measure physically chemically. On one hand, the uptake at high concentration is found mostly contributed by physisorption. other chemisorption dominant low (e.g., air with 2500 ppm of CO2). The simulation results shown that...
Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The inhibit tube formation human umbilical vein endothelial cells (HUVECs) by endogenous ROS. Furthermore, the angiogenesis in chicken ex ovo chorioallantoic membrane assay. results show that antioxidant containing catechol moieties may be useful anti-angiogenic therapy to treat various diseases such as cancer.
A nanosized H<sub>2</sub>S donor micelle releases intracellularly and prevents cardiomyocyte apoptosis in an <italic>in vitro</italic> ischemia model.
Prodrug micelles carrying 5‐(4‐hydroxyphenyl)‐3 H ‐1,2‐dithiole‐3‐thione (ADT‐OH), a compound possessing chemopreventive properties, are prepared from amphiphilic block copolymers linking ADT‐OH via an ester bond using glycine (PAM‐PGlyADT) and isoleucine linkers (PAM‐PIleADT). The release of the PAM‐PIleADT is much slower than PAM‐PGlyADT micelles. show comparable toxicity with in different cancer cell lines, whereas not toxic up to 400 µM. This ADT‐ester prodrug micelle approach enables...
Polymeric nitric oxide (NO) donors were prepared by the conjugation of azide-containing furoxans and poly(ethylene glycol) having an alkyne end group<italic>via</italic>the copper-catalyzed Huisgen cycloaddition.