A5010947227- School Health and Nursing Education
- Diverse Approaches in Healthcare and Education Studies
- Hepatitis B Virus Studies
- Heavy Metal Exposure and Toxicity
- Urban and spatial planning
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Intracranial Aneurysms: Treatment and Complications
- Health and Wellbeing Research
- Body Composition Measurement Techniques
- Urticaria and Related Conditions
- Hepatitis C virus research
- Nutrition, Health and Food Behavior
- Dermatology and Skin Diseases
- Paraquat toxicity studies and treatments
- Parkinson's Disease Mechanisms and Treatments
- Data Visualization and Analytics
- Geriatric Care and Nursing Homes
- Dental Health and Care Utilization
- Nanoplatforms for cancer theranostics
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Health, psychology, and well-being
Toray Industries, Inc. (Japan)
2015-2022
University of California, San Francisco
2018
Nagasaki University
1985-2017
Osaka Institute of Technology
2011-2017
National Institute of Infectious Diseases
2013-2016
Japanese Red Cross Kyushu International College of Nursing
2016
Fukuoka University
2001-2015
Osaka University
2009-2015
Kyoto University
2003-2013
Toray (United States)
2013
In the present study, we showed that SPA-1, a Rap1 GTPase-activating protein (GAP), was bound to cytoskeleton-anchoring AF-6. SPA-1 and AF-6 were co-immunoprecipitated in 293T cells transfected with both cDNAs as well normal thymocytes. vitro binding studies using truncated fragments their mutants suggested PDZ domain of via probable internal ligand motif within GAP-related domain. The conserved among GAPs, it shown rapGAP I comparably SPA-1. RapV12 also N-terminal domain, only presence...
Abstract A prospective follow-up study was carried out to assess the prognosis of renal tubular function after reduction environmental cadmium exposure. Time-related changes in urinary β2-microglobulin and excretion were followed from 1979 1989 102 residents a cadmium-polluted area Nagasaki, Japan. The average dietary intake among population more than 200 μg/d 1969, which decreased approximately half that amount 1983 because paddy fields replaced with new soil 1981. geometric mean...
Chronic atrophic gastritis (CAG) is well known as a precancerous lesion of the stomach, and Helicobacter pylori (H. pylori) infection increases risk CAG. While recent studies have reported that green tea consumption decreases gastric cancer, there has been no study analyzing relationship between both risks H. We conducted cross-sectional on 636 subjects living in farming village Japan to examine among consumption, infection, Smoking, alcohol drinking, four beverages, including tea, five...
Objective Although HCV is a major cause of chronic liver disease worldwide, there currently no prophylactic vaccine for this virus. Thus, the development an that can induce both humoural and cellular immunity urgently needed. To create effective vaccine, we evaluated neutralising antibody induction immune responses following immunisation non-human primate model with cell culture-generated (HCVcc). Design accomplish this, 10 common marmosets were immunised purified, inactivated HCVcc in...
A retrospective cohort study was conducted to investigate the association between cadmium induced renal tubular dysfunction and mortality. total of 230 subjects aged 40 or older living in a polluted area Kosaka Town, Akita Prefecture, Japan, were studied at least once 1975 1977 again 1990. Urinary beta 2-microglobulin amino nitrogen concentrations significantly related mortality from all causes women. The finding supports idea that kidney damage is factor associated with general population...
IWATA, K., SAITO, H., MORIYAMA, M. and NAKANO, A. Association between Renal Tubular Dysfunction Mortality among Residents in a Cadmium-Polluted Area, Nagasaki, Japan. Tohoku J. Exp. Med., 1991, 164 (2), 93-102- A retrospective cohort study was carried out to clarify the effect of exposure environmental cadmium (Cd) on mortality. total 256 residents aged 50 years or older, living Sasu, Cd-polluted area Tsushima Island Nagasaki Prefecture, Japan, were followed from July 1979 February 1989. The...
mGluR6 expression is a characteristic property of retinal ON bipolar cells. also the causal gene for form congenital night blindness. To elucidate physiological and pathological functions cells mGluR6, we thought it important to identify genes specifically expressed in them. We thus made transgenic mouse lines expressing humanized Renilla reniformis green fluorescent protein (hrGFP), under control promoter. From their retina, isolated hrGFP-positive by cell sorting, analysed gene-expression...
Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The inhibit tube formation human umbilical vein endothelial cells (HUVECs) by endogenous ROS. Furthermore, the angiogenesis in chicken ex ovo chorioallantoic membrane assay. results show that antioxidant containing catechol moieties may be useful anti-angiogenic therapy to treat various diseases such as cancer.
Isothermal and Chimeric primer-initiated Amplification of Nucleic acids (ICAN) allows the amplification target DNA under isothermal conditions at around 55 degrees C using only a pair 5'-DNA-RNA-3' chimeric primers, thermostable RNaseH polymerase with strand-displacing activity (H. Mukai et al. J. Biochemistry, in preceding paper this issue). Here we elucidated mechanism ICAN by analysing nicking site RNaseH, behaviour primers extension products. We found that reaction was composed two...
Four cases of uncommon soft tissue tumors were investigated histopathologically. All them consisted fibrous and myxoid components, mature bone showed shell‐like characteristics. Histological features revealed these well circumscribed by a thick collagenous capsule composed uniform‐sized fusiform cells with eosinophilic cytoplasm round or oval nucleus in the matrix. An incomplete shell lamellar structure was also observed at periphery. Immunohistochemical ultrastructural studies performed....
The quality of life (QoL) patients with dementia was investigated from the patient's viewpoint, and role an acceptance in maintaining important distinctive elements QoL analysed by questionnaire interview methods. subjects present study were 18 patients, 21 family members eight staff at a day-care facility Japan. Patients hoped to maintain 'ordinary' way life. Living peacefully, living together, healthily helping each other considered be their QoL. happily is important, but hopes...
A cross-sectional survey of the entire membership Fukuoka Prefecture Medical Association was conducted in 1933 using a self-administered questionnaire. In this investigation actual prevalence smoking among physicians and relationship between their habits living were studied. The study subjects divided into two groups: those who smoked (1, 737 men 17 women), did not currently smoke (2, 267 169 women). It realized that there many non-smokers women, with high body mass index, heart disease,...
To examine the mutual association of risk factors for both Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis (CAG), a cross-sectional study on 954 residents rural town in Japan was conducted. Using an unconditional logistic model, we calculated odds ratios (ORs) H. according to each lifestyle, as well ORs CAG lifestyle infection. A significant positive observed between (OR = 6.29). On other hand, negative high consumption light-colored vegetables 0.68). We also used...
The possibility of establishing a new method treatment against pulmonary fibrosis caused by acute paraquat intoxication, which takes into consideration the role heat shock protein 60 (HSP60), was investigated in paraquat-exposed rat lung mitochondria. In polyacrylamide electrophoresis, mitochondrial bands appeared, especially range molecular weight kDa and higher, whereas disappeared 20-40 on 4th day after exposure. profile normalized 7th no remarkable changes were seen thereafter up to 56th...