A5055823237- Prostate Cancer Treatment and Research
- Genetic and Kidney Cyst Diseases
- Kidney Stones and Urolithiasis Treatments
- Prostate Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Urinary Bladder and Prostate Research
- Adrenal and Paraganglionic Tumors
- Monoclonal and Polyclonal Antibodies Research
- Renal Diseases and Glomerulopathies
- Cancer Cells and Metastasis
- Pelvic floor disorders treatments
- Ureteral procedures and complications
- Minimally Invasive Surgical Techniques
- Biomedical Research and Pathophysiology
- Cancer Genomics and Diagnostics
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
Kyorin University
2012-2022
Kawasaki Hospital
2020
Kyorin (United States)
2011
The University of Texas Southwestern Medical Center
2005
The University of Tokyo
1984-1994
To determine differences in patients' characteristics, operative time and procedures, perioperative outcomes between prone supine positioning percutaneous nephrolithotomy (PCNL) using the Clinical Research Office of Endourological Society (CROES) PCNL Global Study database.Between November 2007 December 2009, prospective data were collected on a total 5803 consecutive patients who treated over 1-year period at each 96 participating global centers. Patients with body position dichotomized...
Autosomal dominant polycystic kidney disease (ADPKD), a frequent cause of end-stage renal disease, has no cure. V2-specific vasopressin receptor antagonists delay progression in animal models.This is prospectively designed analysis annual total volume (TKV) and thrice estimated GFR (eGFR) measurements, from two 3-year studies tolvaptan 63 ADPKD subjects randomly matched 1:2 to historical controls by gender, hypertension, age, baseline TKV or eGFR. Prespecified end points were group...
Laparoscopic left adrenalectomy was performed on a 47 years old male patient with primary aldosteronism. Subcutaneous steel traction method utilized in addition to intraperitoneal CO2 insufflation method. The combined use of reduced pressure below 12mmHg and might reduce possibility CO2-related complications. A adrenal gland approached by resection phrenicocolic ligament transverse descending colon. has distinct advantages over open terms avoidance skin muscle incision rib resection, early...
No AccessJournal of UrologyOriginal Articles1 May 1993Laparoscopic Adrenalectomy: The Initial 3 Cases Eiji Higashihara, Yoshinori Tanaka, Shigeo Horie, Seiji Aruga, Kikuo Nutahara, Shigeru Minowada, and Yoshio Aso HigashiharaEiji Higashihara More articles by this author , TanakaYoshinori Tanaka HorieShigeo Horie ArugaSeiji Aruga NutaharaKikuo Nutahara MinowadaShigeru Minowada AsoYoshio View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36271-7AboutPDF ToolsAdd to...
Metabolic alteration constitutes a hallmark of cancer. Glycolysis and antioxidant pathways in kidney cancer are elevated, with frequent mutation the VHL gene. Intratumor genetic heterogeneity has been recently demonstrated However, intratumor metabolic not investigated. Here, we used global metabolomics analysis tissue slice tracer studies to demonstrate that different portions human primary tumor possess characteristics drug sensitivity. Pyruvate levels were elevated pyruvate metabolism was...
Acute pyelonephritis (APN) with obstructive uropathy is not uncommon and often causes serious conditions including sepsis septic shock. We assessed the risk factors for shock in patients APN associated upper urinary tract calculi. retrospectively studied 69 calculi who were admitted to our hospital. Emergency drainage decompression of renal collecting system was performed empirical treatment cases failure initial severe cases. by multivariate logistic regression analysis. Overall, 45 (65.2...
The clinical effects of increased water intake on autosomal dominant polycystic kidney disease (ADPKD) progression are unknown. ADPKD patients with creatinine clearance ≧50 mL/min/1.73 m2 were divided into high (H-, n = 18) and free (F-, 16) water-intake groups, mainly according to their preference. Prior the study, 30 underwent annual evaluation total volume (TKV) 24-h urine for an average 33 months. During 1-year study period, TKV analyzed at beginning end every 4 months, respectively....
Objective We examined whether androgen receptor splice variant 7 (AR‐V7) in circulating tumor cell(CTC)clusters can be used to predict survival patients with bone metastatic castration resistant‐prostate cancer (mCRPC) treated abiraterone or enzalutamide. Methods retrospectively enrolled 98 CRPC on enzalutamide, and investigated the prognostic value of CTC cluster detection (+ v −) AR‐V7 using a − based mRNA assay. ≤50% prostate‐specific antigen (PSA) responses, PSA progression‐free...
The prevalence and renal prognosis of diagnosed autosomal dominant polycystic kidney disease (ADPKD) in Japan were estimated. Hospital-based nationwide surveys conducted 1995. number ADPKD patients who visited hospitals but not on chronic dialysis was estimated to be 10,000 (95% confidence interval: 8,200–11,900) that 4,590, yielding a 117 per million population at the end 1994 102–132). increased with age reached peak value 261 group 55–59 years. rate end-stage among living calculated based...
<i>Background:</i> Although hypertension is commonly found in patients with autosomal dominant polycystic kidney disease (ADPKD), there no consensus about which antihypertensive agents are most appropriate. The effects of calcium channel blockers (CCB) and angiotensin II receptor (ARB) on blood pressure renoprotection were compared hypertensive ADPKD. <i>Methods:</i> We randomly assigned 49 participants to CCB amlodipine-based (2.5–10 mg/day) or ARB candesartan-based...
Using the CellSearch System we evaluated whether circulating tumor cells predict survival in patients with hormone refractory prostate cancer.Circulating were counted whole blood. This system was developed using epithelial cell adhesion cancer antibody based, immunomagnetic capture and automated staining methodology. Blood samples from 64 analyzed.A threshold of 5 or more per 7.5 ml blood used to evaluate ability survival. Patient charts retrospectively examined determine median overall...
Origins of the guidelinesAutosomal dominant polycystic kidney disease (ADPKD) is most common hereditary disease, with approximately half patients experiencing end-stage renal by age 60.Bilateral cysts progressively proliferate and enlarge, even as complications such hypertension, hepatic cysts, intracranial aneurysms lead to more lethal events cyst infections ruptured prior disease.Early-stage diagnosis intervention are recognized being vital.Autosomal recessive (ARPKD) estimated occur in 1...
No AccessJournal of Urology1 Feb 1990Long-Term Consequence Nephrectomy Eiji Higashihara, Shigeo Horie, Takumi Takeuchi, Kikuo Nutahara, and Yoshio Aso HigashiharaEiji Higashihara , HorieShigeo Horie TakeuchiTakumi Takeuchi NutaharaKikuo Nutahara AsoYoshio View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39922-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Renal function blood pressure were assessed in 139...
No AccessJournal of UrologyAdult Urology1 Oct 2008Immunomagnetic Quantification Circulating Tumor Cells as a Prognostic Factor Androgen Deprivation Responsiveness in Patients With Hormone Naive Metastatic Prostate Canceris accompanied byWAVE1 is Associated Invasiveness and Growth Cancer Takatsugu Okegawa, Kikuo Nutahara, Eiji Higashihara OkegawaTakatsugu Okegawa , NutaharaKikuo Nutahara HigashiharaEiji View All Author Informationhttps://doi.org/10.1016/j.juro.2008.06.021AboutFull TextPDF...
<b><i>Background:</i></b> Kidney volume (KV) becomes clinically relevant in autosomal dominant polycystic kidney disease (ADPKD) management. KV can be conveniently estimated (ceKV) using ellipsoid equations with three axes measurements; however, the accuracy and reliability are unknown. <b><i>Methods:</i></b> KVs of 347 kidneys 177 consecutive ADPKD patients were determined a volumetric method (standard-KV), ceKV was calculated six different...
Objectives To compare persistence with medication and the reasons for discontinuation of mirabegron or solifenacin therapy up to12 months in women overactive bladder ( OAB ). Methods Female patients who presented to women's urology clinics were enrolled a prospective, randomized, two‐arm study. Patients randomized receive at 25–50 mg n = 76) 2.5–5 72). The rate investigated 12 months. Results 12‐month was 12.2% group versus 20.1% there no significant differences rates during study (n.s)....
Genetic testing of PKD1 and PKD2 is expected to play an increasingly important role in determining allelic influences autosomal dominant polycystic kidney disease (ADPKD) the near future. However, date, genetic not commonly employed because it expensive, complicated heterogeneity, does easily identify pathogenic variants. In this study, we developed a system based on next-generation sequencing (NGS), long-range polymerase chain reaction, new software package. The package integrated seven...
To assess whether circulating tumor cells with tumor-related methylated DNA can be used to predict survival in patients hormone-refractory prostate cancer.Blood samples from 76 cancer were analyzed. Circulating enumerated the CellSearch System whole blood. This system was developed using an epithelial cell adhesion molecule antibody-based immunomagnetic capture and automated staining methodology. Hypermethylation at adenomatosis polyposis coli, glutathione-S-transferase-pi,...
Autosomal dominant polycystic kidney disease is a lifelong progressive disorder. However, how age, blood pressure, and stage of chronic (CKD) affect the rate function deterioration not clearly understood.In this long-term observational case study up to 13.9 years (median observation period for slope was 3.3 years), serum creatinine serially measured in 255 mostly adult patients. The glomerular filtration estimated (eGFR) using modified Modification Diet Renal Disease Study method. total...
Background: The aim of this study was to investigate the outcome laparoscopic excision urachal remnants (LUR), and compare with that traditional open (OUR). Methods: Between February 2001 December 2005, six patients a mean age 23.8 years who had symptomatic sinus underwent radical LUR. Using 12 mm 5 ports, caudal stump urachus ligated an absorbable clip divided. peritoneal preperitoneal tissue between medial umbilical ligaments dissected free transversalis fascia. Dissection carried out...