A5101698630- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Adipose Tissue and Metabolism
- Brain Metastases and Treatment
- Insect and Arachnid Ecology and Behavior
- Tryptophan and brain disorders
- Medical Image Segmentation Techniques
- Advanced X-ray and CT Imaging
- Retinal Development and Disorders
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Cell Image Analysis Techniques
- Neurotransmitter Receptor Influence on Behavior
- Cancer-related cognitive impairment studies
- Bipolar Disorder and Treatment
- Cardiac Ischemia and Reperfusion
- Traditional Chinese Medicine Analysis
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
Central Institute of Mental Health
2011-2021
Heidelberg University
2011-2021
University Hospital Heidelberg
2012-2021
Southern Medical University
2020
Liaocheng People's Hospital
2015-2019
University of Sheffield
2006-2019
University Medical Centre Mannheim
2011-2016
University of Cambridge
2006
Abstract Magnetic resonance imaging (MRI) of the brain combined with voxel-based morphometry (VBM) revealed changes in gray matter volume (GMV) various disorders. However, cellular basis GMV has remained largely unclear. We correlated metrics by mice MRI and two-photon vivo microscopy at three time points within 12 weeks, taking advantage age-dependent structure. Imaging fluorescent cell nuclei allowed inferences on (i) physical tissue as determined from reference spaces outlined nuclei,...
At the layer of first visual synapses, information from photoreceptors is processed and transmitted towards brain. In fly compound eye, output (R1-R6) that share same field pooled via histaminergic synapses to two classes interneuron, large monopolar cells (LMCs) amacrine (ACs). The interneurons also feed back photoreceptor terminals numerous ligand-gated yet significance these connections has remained a mystery. We investigated role feedback by comparing intracellular responses LMCs in...
Ginsenosides, a class of ginseng compounds herbal medicine, have been shown to therapeutic potential for the neuroprotection brain damage after cerebral ischemia because their activities including anti-oxidant and anti-inflammation. In elderly population, aging-induced oxidative stress has implicated in exacerbating injury, which might also be ameliorated by anti-oxidants, such as ginsenosides. However, this hypothesis yet explored.Here we present vivo studies highlighting protective...
Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings wheel running by longitudinal magnetic resonance imaging. Voxel-based morphometry revealed that increases hippocampal volume inhibiting an early age-related gray matter loss. Disruption of neurogenesis-related neuroplasticity focalized irradiation is sufficient to block positive effects exercise on macroscopic brain morphology.
Objectives. Recent evidence suggests that alterations in hippocampal glutamate and γ-aminobutyric acid (GABA) are associated with the pathomechanism of depression treatment effects electroconvulsive therapy (ECT). Thus, proton magnetic resonance spectroscopy (1H MRS) at a 9.4 T animal system seems promising tool to study underlying mechanisms since it allows for an accurate quantification metabolites distinction glutamate, GABA glutamine, as well separation taurine from choline. Methods. A...
Retinal networks must adapt constantly to best present the ever changing visual world brain. Here we test hypothesis that adaptation is a result of different mechanisms at several synaptic connections within network. In companion paper (Part I), showed in photoreceptors (R1–R6) and large monopolar cells (LMC) Drosophila eye improves sensitivity under-represented signals seconds by enhancing both amplitude frequency distribution LMCs' voltage responses repeated naturalistic contrast series....
Chronic alcohol consumption is a critical contributing factor to ischemic stroke, as it enhances ischemia-induced glutamate release, leading more severe excitotoxicity and brain damage. But the neural mechanisms underlying this phenomenon are poorly understood.We evaluated effects of chronic exposure on modulation release via CB1 CB2 cannabinoid receptors during middle cerebral artery occlusion, using in vivo microdialysis coupled with high-performance liquid chromatography, alcohol-naïve...
Purpose Urinary particles are particularly important parameters in clinical urinalysis, especially for the diagnosis of nephropathy. Therefore, it is highly to precisely detect urinary setting. However, artificial microscopy subjective and time consuming, various previous detection algorithms lack adequate accuracy. In this study, a method proposed analysis based on deep learning. Methods We used seven cellular components (i.e., erythrocytes, leukocytes, epithelial, low‐transitional...
Ca2+-activated K+ channels (BK and SK) are ubiquitous in synaptic circuits, but their role network adaptation sensory perception remains largely unknown. Using electrophysiological behavioral assays biophysical modeling, we discover how visual information transfer mutants lacking the BK channel (dSlo- ), SK (dSK- or both ;; dSlo- ) is shaped female fruit fly (Drosophila melanogaster) R1-R6 photoreceptor-LMC circuits (R-LMC-R system) through feedforward-feedback interactions reduced Shaker...
The investigation of structural brain alterations is one focus in research diseases like depression. Voxel-based morphometry (VBM) based on high-resolution 3D MRI images a widely used non-invasive tool for such investigations. However, the result VBM might be sensitive to local physiological parameters as regional cerebral blood volume (rCBV) changes. In order investigate whether rCBV changes may contribute variation VBM, we performed analyses study with congenital learned helplessness (cLH)...