A5074692411- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Treatment of Major Depression
- Tryptophan and brain disorders
- Advanced NMR Techniques and Applications
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Photoreceptor and optogenetics research
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Alcoholism and Thiamine Deficiency
- Electron Spin Resonance Studies
- Adipose Tissue and Metabolism
- Neural and Behavioral Psychology Studies
- Diet and metabolism studies
- Attention Deficit Hyperactivity Disorder
- Congenital heart defects research
- Neuroinflammation and Neurodegeneration Mechanisms
- Obsessive-Compulsive Spectrum Disorders
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
Central Institute of Mental Health
2015-2024
Universität Hamburg
2004-2012
University of Mannheim
2011
University Medical Center Hamburg-Eppendorf
2004-2008
DKFZ-ZMBH Alliance
1998
German Cancer Research Center
1998
Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer the possibility to non-invasively probe whole-brain network dynamics and investigate determinants altered signatures observed in human studies. Mouse rsfMRI has been increasingly adopted by numerous laboratories worldwide. Here we describe a multi-centre comparison 17 mouse datasets via common image processing analysis pipeline. Despite prominent cross-laboratory differences equipment procedures,...
<h3>Background</h3> We monitored the effect of electroconvulsive therapy (ECT) on nuclear magnetic resonance–detectable metabolites<i>N</i>-acetylaspartate, creatine and phosphocreatine, choline-containing compounds in hippocampus by means hydrogen 1 resonance spectroscopic imaging. hypothesized that if ECT-induced memory deterioration was associated with neuronal loss hippocampus, the<i>N</i>-acetylaspartate signal would decrease after ECT any increased membrane turnover result an increase...
Abstract Magnetic resonance imaging (MRI) of the brain combined with voxel-based morphometry (VBM) revealed changes in gray matter volume (GMV) various disorders. However, cellular basis GMV has remained largely unclear. We correlated metrics by mice MRI and two-photon vivo microscopy at three time points within 12 weeks, taking advantage age-dependent structure. Imaging fluorescent cell nuclei allowed inferences on (i) physical tissue as determined from reference spaces outlined nuclei,...
<h3>Background</h3> Schizophrenic disorders are thought to involve widespread abnormalities in information processing. The present study used functional magnetic resonance imaging and a simple robust paradigm that involved auditory visual activation examine basic sensory input circuits. Our aim was determine which stages of the processing network disturbed first-episode schizophrenic patients. <h3>Methods</h3> Twelve neuroleptic-naive inpatients (paranoid subtype) were compared with 11...
Context: Dysfunction and deficits in the structure of anterior cingulate cortex have been reported borderline personality disorder (BPD).To our knowledge, there is only 1 published study to date investigating metabolism subjects with BPD co-occurring attention-deficit/hyperactivity using proton magnetic resonance spectroscopy.Impulsivity a key feature can be related function.Objective: To investigate whether may altered correlates pathology.
Abstract Despite MEGA‐PRESS being a robust method for editing the GABA resonance, there are macromolecule resonances at same chemical shift that coedited with this sequence. Although is known problem, it still often overlooked. We aimed to evaluate amount of signal coedited, as well gender and age dependencies resonance 3.01 ppm using two different pulse frequencies. Forty‐five healthy subjects (21–52 years) were included in an vivo single voxel study 3.0 T. Phantom measurements conducted...
Neuropathic pain affects multiple brain functions, including motivational processing. However, little is known about the structural and functional changes involved in transition from an acute to a chronic state. Here we combined behavioral phenotyping of thresholds with multimodal neuroimaging longitudinally monitor metabolism, structure connectivity using spared nerve injury (SNI) mouse model neuropathic pain. We investigated stimulus-evoked responses prior SNI surgery, one twelve weeks...
Abstract Silencing of dopamine transporter (DAT), a main controlling factor dopaminergic signaling, results in biochemical and behavioral features characteristic for neuropsychiatric diseases with presumed hyperdopaminergia including schizophrenia, attention deficit hyperactivity disorder (ADHD), bipolar disorder, obsessive-compulsive (OCD). Investigation DAT silencing thus provides transdiagnostic approach towards systems-level understanding common underlying pathways. Using high-field...
In humans, resting-state blood oxygen level-dependent (BOLD) signals in the default mode network (DMN) are temporally anti-correlated with those from a lateral cortical involving frontal eye fields, secondary somatosensory and posterior insular cortices. Here, we demonstrate existence of an analogous rat brain, extending laterally anterior sensorimotor regions to cortex exhibiting low-frequency BOLD fluctuations that midline "DMN-like" comprising posterior/anterior cingulate prefrontal The...
Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. The neurological phenotypes different rodent models CD vary considerably. Here we report on novel targeted aspa mouse mutant expressing bacterial β-Galactosidase (lacZ) under control regulatory elements. X-Gal staining known ASPA expression domains confirms...
The development and maintenance of alcohol use disorders (AUD) have been hypothesized to be associated with an imbalance glutamate (GLU) homeostasis. White matter (WM) loss, especially in anterior brain regions, has reported dependence, which may involve disturbances both myelin axonal integrity. Frontal lobe dysfunction plays important role addiction, because it is suggested the loss control over substance use. This study investigated magnetic resonance spectroscopy (MRS)-detectable Glu...
In the present study, we evaluated 23 chronic schizophrenic patients under stable clinical conditions to determine association between neuronal viability, as measured by in vivo 1H magnetic resonance spectroscopic imaging (MRSI), and antipsychotic drug effects anterior cingulate cortex. Careful screening of medication history showed that 11 these had been treated with traditional neuroleptics only, while others switched atypical antipsychotics due non-response drugs. The group receiving...
The present study combined optimized voxel-based morphometry and diffusion tensor imaging to detect age-related brain changes. We compared grey matter density maps (grey morphometry) white fractional anisotropy (diffusion imaging-voxel-based between two groups of 17 younger older women. Older women exhibited reduced as well decreased most prominently in the frontal, limbic, parietal temporal lobes. A discriminant analysis identified four frontal limbic areas that separated effectively....