A5004470258- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Fungal Infections and Studies
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Streptococcal Infections and Treatments
- Herpesvirus Infections and Treatments
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Cancer-related Molecular Pathways
- AI in cancer detection
- Cleft Lip and Palate Research
- Radiomics and Machine Learning in Medical Imaging
- CRISPR and Genetic Engineering
- Cutaneous lymphoproliferative disorders research
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
Université de franche-comté
2021-2024
Inserm
2021-2024
Centre Hospitalier Universitaire de Besançon
2019-2024
Université de Bourgogne
2023
CHU Dijon Bourgogne
2022
Université Bourgogne Franche-Comté
2021
In oncology, liquid biopsy is of major relevance from theranostic point view. The searching for mutations in circulating tumor DNA (ctDNA) case colorectal cancers (CRCs) allows the optimization patient care. this context, independent mutation status biomarkers are required its detection to confirm presence ctDNA biopsies. Indeed, hypermethylation NPY and WIF1 genes appear be an ideal biomarker specific CRCs. objective work develop research by Crystal Digital PCR™ CRCs.Detection...
Introduction: Exome sequencing has a diagnostic yield ranging from 25% to 70% in rare diseases and regularly implicates genes novel disorders. Retrospective data reanalysis demonstrated strong efficacy improving diagnosis, but poses organizational difficulties for clinical laboratories. Patients methods: We applied strategy based on intensive prospective bibliographic monitoring along with direct application of the GREP command-line tool (to “globally search regular expression print matching...
Breast cancers expressing high levels of Ki67 are associated with poor outcomes. Oncotype DX test was designed for ER+/HER2- early-stage breast to help adjuvant chemotherapy decision by providing a Recurrent Score (RS). RS measures the expression 21 specific genes from tumor tissue, including Ki67. The primary aim this study assess agreement between Ki67RNA obtained and Ki67IHC. Other objectives were analyze association event free survival (EFS) level Ki67RNA; Ki67RNA. Herein, we report low...
Human papillomavirus (HPV) is a risk factor for head and neck squamous cell carcinoma (HNSCC), which currently increasing worldwide. We evaluated the prevalence of HPV DNA p16 expression in HNSCC patients age <45 years compared with aged ≥45 years.Thirty-nine who presented at Besançon University Hospital since 2005 were included this retrospective study. was detected by genotyping determined immunohistochemistry using paraffin-embedded tissues. A matched-group 38 from included.The overall...
EMT is a reversible cellular process that linked to gene expression reprogramming, which allows for epithelial cells undergo phenotypic switch acquire mesenchymal properties. associated with cancer progression and therapeutic resistance it known that, during the EMT, many stress response pathways, such as autophagy NMD, are dysregulated. Therefore, our goal was study regulation of ATG8 family members (GABARAP, GABARAPL1, LC3B) by NMD identify molecular links between these two processes...
HER2-targeted therapies have recently emerged as an option in the management of metastatic colorectal cancer (mCRC) overexpressing HER2. However, data regarding HER2 status primary CRC and its corresponding liver metastases are limited, potentially influencing clinical decisions. Therefore, aim this study was to compare paired metastases.
Colorectal cancer is a public health issue and was the third leading cause of cancer-related death worldwide in 2022. Early diagnosis can improve prognosis, making screening central part colorectal management. Blood-based screening, follow-up patients are possible with study cell-free circulating tumor DNA. This aimed to identify novel DNA methylation biomarkers that be used for cancer. A profile established Gene Expression Omnibus (GEO) database (n = 507) using bioinformatics analysis...
In colorectal cancer (CRC), HER2 targeting is a promising treatment and immune infiltrate an important area of research strategy. Data regarding status are lacking. The aim this study was to compare the between amplified non-amplified categories in proficient MisMatchRepair (pMMR)/microsatellite stable (MSS) CRC.
Purpose: Exome sequencing has a diagnostic yield ranging from 25% to 70% in rare diseases and regularly implicates genes novel disorders. Prospective data reanalysis demonstrated strong efficacy improving diagnosis, but poses organizational difficulties for clinical laboratories. We applied strategy based on intensive prospective bibliographic monitoring, directly the Globally search Regular Expression Print matching lines (GREP) command-line massive ES database. Methods: For 18 months, we...
Abstract Background: Breast cancers expressing high levels of Ki67 are associated with poor outcomes. To provide individualized patient care, reliability prognostic and predictive information deriving from assessment is essential. Oncotype DX ® test was designed for ER+/HER2- early-stage breast to help adjuvant chemotherapy decision by providing a Recurrent Score (RS ). RS measures the expression 21 specific genes tumor tissue, including , aim predict benefit risk distant recurrence. The...
Abstract Breast cancers expressing high levels of Ki67 are associated with poor outcomes. Oncotype DX ® test was designed for ER+/HER2- early-stage breast to help adjuvant chemotherapy decision by providing a Recurrent Score (RS ). RS measures the expression 21 specific genes from tumor tissue, including . The primary aim this study assess agreement between RNA obtained and IHC Other objectives were analyze association event free survival (EFS) level ; .Herein, we report low 0.24 Cohen’s...