A5009924576- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Medical Image Segmentation Techniques
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Brain Tumor Detection and Classification
- Dementia and Cognitive Impairment Research
- Advanced Neural Network Applications
- Retinal Imaging and Analysis
- Image and Signal Denoising Methods
- Artificial Intelligence in Healthcare and Education
- Neonatal and fetal brain pathology
- Medical Imaging and Analysis
- Advanced X-ray and CT Imaging
- Sparse and Compressive Sensing Techniques
- Neurological Disease Mechanisms and Treatments
- Mental Health Research Topics
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Plant and Fungal Interactions Research
- Smart Agriculture and AI
- Attention Deficit Hyperactivity Disorder
Beihang University
2020-2025
Beijing Normal University
2023-2024
Tarim University
2024
Beijing Advanced Sciences and Innovation Center
2020
Alzheimer's disease (AD) is a chronic neurodegenerative disease, and its long-term progression prediction definitely important. The structural Magnetic Resonance Imaging (sMRI) can be used to characterize the cortical atrophy that closely coupled with clinical symptoms in AD prodromal stages. Many existing methods have focused on predicting cognitive scores at future time-points using set of morphological features derived from sMRI. 3D sMRI provide more massive information than scores....
Abstract Functional signals emerge from the structural network, supporting multiple cognitive processes through underlying molecular mechanism. The link between human brain structure and function is region‐specific hierarchical across neocortex. However, relationship structure–function decoupling manifestation of individual behavior cognition, along with significance functional systems involved, specific mechanism remain incompletely characterized. Here, we used structural‐decoupling index...
The development of automated grading equipment requires achieving high throughput and precise detection disease spots on jujubes. However, the current algorithms are inadequate in accomplishing these objectives due to their density, varying sizes shapes, limited location information regarding This paper proposes a method called JujubeSSD, boost precision identifying jujubes based single shot multi-box detector (SSD) network. In this study, diverse dataset comprising varied densities,...
Abstract Episodic memory is the ability to remember events from our past accurately. The process of pattern separation hypothesized underpin this and defined as capacity orthogonalize traces, maximize features that make them unique. Contemporary cognitive neuroscience suggests entails complex interactions between hippocampus neocortex, where specific hippocampal subregions shape neural reinstatement in neocortex. To test hypothesis, current work studied both healthy controls patients with...
Abstract The hippocampus plays a critical role in memory and is prone to neural degenerative diseases. Its complex structure distinct subfields pose challenges for automatic segmentation 3 T MRI because of its limited resolution contrast. While 7 offers superior anatomical details better gray-white matter contrast, aiding clearer differentiation hippocampal structures, use restricted by high costs. To bridge this gap, algorithms synthesizing 7T-like images from scans are being developed,...
From childhood to adolescence, the structural organization of human brain undergoes dynamic and regionally heterogeneous changes across multiple scales, from synapses macroscale white matter pathways. However, during this period, developmental process multiscale architecture, its association with cortical morphological changes, role in maturation functional remain largely unknown. Here, using two independent multimodal imaging datasets aged 6–14 years, we investigated by constructing an vivo...
Alzheimer's disease and amnestic mild cognitive impairment are associated with disrupted functional organization in brain networks, involved alteration of segregation. Connectome gradients a new tool representing topological to smoothly capture the human macroscale hierarchy. Here, we examined altered by connectome gradient mapping. We further quantified segregation dispersion. Then, systematically compared alterations observed patients those normal controls two-dimensional space from both...
Highlights•Brain hubs shift from primary to association regions during the first 1,000 days of life•Functional segregation and integration develop along an anterior-posterior axis•Neonatal connectomes predict cognitive language outcomes at 1.5 years age•Network growth is regulated by genes involved in neurodevelopment metabolismSummaryThe human life lay foundation for brain development later growth. However, developmental rules functional connectome this critical period remain unclear. Using...
Precise delineation of hippocampus subfields is crucial for the identification and management various neurological psychiatric disorders. However, segmenting these automatically in routine 3T MRI challenging due to their complex morphology small size, as well limited signal contrast resolution images. This research proposes Syn_SegNet, an end-to-end, multitask joint deep neural network that leverages ultrahigh-field 7T synthesis improve hippocampal subfield segmentation MRI. Our approach...
From childhood to adolescence, the structural organization of human brain undergoes dynamic and regionally heterogeneous changes across multiple scales, from synaptic pruning reorganization large-scale anatomical wiring. However, during this period, developmental process multiscale architecture, its association with cortical morphological changes, role in maturation functional remain largely unknown. Here, we utilized a longitudinal multimodal imaging dataset including 276 children aged 6 14...
<title>Abstract</title> Throughout childhood and adolescence, the development of motor skills cognitive functions is accompanied by concurrent changes in morphology cortical sulci. In this study, we analyzed structural MRI (sMRI) data from a longitudinal cohort 312 children (145 females) aged 6 to 14 years reconstruct label brain's sulci, followed mixed-effects modeling assess age-related morphological changes. We further investigated relationship between during period via least absolute...
Efficient and accurate segmentation of hippocampi from preterm aging brain MR images is one the most fundamental steps in understanding hippocampal growth development or diagnosing monitoring various clinical conditions. Current hippocampus methods for are limited due to: 1) they can rarely achieve infant segmentation; 2) computation cost high; 3) current deep learning models cannot well handle feature learning; 4) not open obtainable. To deal with these problems, we propose an efficient,...
A bstract Episodic memory is our ability to remember past events accurately. Pattern separation, the process of orthogonalizing similar aspects external information into nonoverlapping representations, one its mechanisms. Converging evidence suggests a pivotal role hippocampus, in concert with neocortical areas, this process. The current study aimed identify principal dimensions functional activation associated pattern separation hippocampal and both healthy individuals patients lesions...
The intrinsic neural timescale (INT) provides temporal windows in brain activity that process information of different durations, crucial for the integration and segregation external inputs ultimately shaping cognition behavior. Recent research has uncovered a pronounced INT hierarchy along adult hippocampus's long-axis. Yet, development organization within hippocampus—particularly pattern its hierarchical structure impact on cognitive development—has not been thoroughly investigated youth....
Motivation: The hippocampus plays a pivotal role in cognition, hosting an intrinsic neural timescale hierarchy. Goal(s): How does this hierarchy within the hippocampal subfield evolve throughout childhood and adolescence?Approach: Our study encompasses 300 healthy children (6-14 years). We characterized by assessing decay of temporal autocorrelation function (ACF) utilized mixed-effect model to chart developmental trajectories. Results: Group-level timescales subfields show clear hierarchies...
Abstract The reorganization of human hippocampus, especially its interaction with cortex, remains largely undefined in youth. organization a single hippocampal long-axis has been predominantly characterized as monotonic 1–6 , despite recent indications nonmonotonic features neuron density 7 and geometric eigenmodes 8 . While the cortical hierarchy well recognized for significant developmental evolutionary advantages 9–12 hippocampus typically considered an evolutionarily conserved brain...
Previous studies have shown that amnestic mild cognitive impairment (aMCI) involves in the morphological abnormalities of multiple regions, including cortical thickness, sulcus depth, surface area, gray matter volume, jacobian metric and average curvature. All measures unique neuropathological genetic meanings. However, most existing methods simply or concatenate these when constructing classifiers, which may include redundant information ignore relationships among them. In this study, we...
Abstract Background Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI) are associated with disrupted functional organization in brain networks, yet the finer changes topological aMCI AD remain to be investigated. Connectome gradients a new tool representing low-dimensional space smoothly capture human macroscale hierarchy. Methods Here, we examined altered by connectome gradient mapping. We further quantified segregation dispersion. Then, systematically compared...