A5006238757- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Luminescence and Fluorescent Materials
- Neural dynamics and brain function
- Synthesis and Properties of Aromatic Compounds
- Radical Photochemical Reactions
- Organic Light-Emitting Diodes Research
- Neuroscience and Neuropharmacology Research
- High-Velocity Impact and Material Behavior
- Organic Electronics and Photovoltaics
- Nanoplatforms for cancer theranostics
- Mechanical Behavior of Composites
- Neonatal and fetal brain pathology
- Building materials and conservation
- Matrix Theory and Algorithms
- Fullerene Chemistry and Applications
- Photochromic and Fluorescence Chemistry
- Reading and Literacy Development
- Gene Regulatory Network Analysis
- EEG and Brain-Computer Interfaces
Beijing Normal University
2017-2025
Tsinghua University
2024
Chinese Institute for Brain Research
2018-2024
Southern University of Science and Technology
2024
State Key Laboratory of Chemobiosensing and Chemometrics
2019-2023
Hunan University
2019-2023
State Key Laboratory of Cognitive Neuroscience and Learning
2017-2023
Xi'an University of Science and Technology
2023
Shenzhen University
2022
First Affiliated Hospital of Kunming Medical University
2021
Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network, capturing functional spectrum that ranges from perception and action to abstract cognition. However, how this pattern develops whether its development is linked cognitive growth, topological reorganization, gene expression profiles remain largely unknown. Using longitudinal resting-state magnetic resonance imaging data 305 children (aged 6-14 years), we describe substantial...
The default-mode network (DMN) is a set of functionally connected regions that play crucial roles in internal cognitive processing. Previous resting-state fMRI studies have demonstrated the intrinsic functional organization DMN undergoes remarkable reconfigurations during childhood and adolescence. However, these mainly focused on cross-sectional designs with small sample sizes, limiting consistency interpretations findings. Here, we used large longitudinal data comprising 305 typically...
In an increasingly aging society, it is of great importance to consider trajectories subcortical volumes at different ages for understanding biological markers aging. Thus, we investigated sex, age, and their interactions on volumes, including the basal ganglia (caudate, putamen, accumbens, pallidum), thalamus, hippocampus, amygdala.We analyzed adult lifespan trajectory asymmetries in 563 healthy subjects aged from 19 86 using magnetic resonance imaging (MRI) data publicly available 7IXI...
Abstract Cortical thinning is an important hallmark of the maturation brain morphology during childhood and adolescence. However, connectome-based wiring mechanism that underlies cortical remains unclear. Here, we show patterns primarily located in lateral frontal parietal heteromodal nodes adolescence, which are structurally constrained by white matter network architecture particularly represented using a network-based diffusion model. Furthermore, constraints regionally heterogeneous, with...
Extension of oxygen-embedded polycyclic aromatic hydrocarbons (PAHs), in particular with a defined topology, is synthetically challenging primarily because limited regio-specific methods and poor solubility PAHs. We reported herein an efficient way to construct quinoidal pentacenes nonacenes regular zigzag O-inserted edges. These O-embedded backbones composed benzene, pyranyl, cyclohexa-1,4-diene moieties provided access new class longitudinally conjugated acenes superior stability. Their...
The lifespan growth of the functional connectome remains unknown. Here, we assemble task-free and structural magnetic resonance imaging data from 33,250 individuals aged 32 postmenstrual weeks to 80 years 132 global sites. We report critical inflection points in nonlinear curves mean variance connectome, peaking late fourth third decades life, respectively. After constructing a fine-grained, lifespan-wide suite system-level brain atlases, show distinct maturation timelines for segregation...
Open AccessCCS ChemistryCOMMUNICATION6 Jun 2022A Simple Approach to Achieve Organic Radicals with Unusual Solid-State Emission and Persistent Stability Xueqian Zhao†, Junyi Gong†, Parvej Alam, Chao Ma, Yanpei Wang, Jing Guo, Zebin Zeng, Zikai He, Herman H. Y. Sung, Ian D. Williams, Kam Sing Wong, Sijie Chen, Jacky W. Lam, Zheng Zhao Ben Zhong Tang Zhao† Department of Chemistry, Hong Kong Branch Chinese National Engineering Research Center for Tissue Restoration Reconstruction, Institute...
Here we report stepwise solution-synthesis of linear nonalternant nanoribbons (NNRs), featuring pentagonal rings peri-fused onto the repeating perylene unit. The X-ray single-crystal structures demonstrated their π-backbones as a twisted ribbon, with longest crystalline length nanoribbon up to 3.9 nm. NNRs exhibited an orange deep-red photoluminescence even under room light, absolute ΦF 82 %, most likely due ring-strain induced molecular stiffness. Benefiting from enlarged size and...
Abstract Doping is of great importance to tailor the electrical properties semiconductors. However, present doping methodologies for organic semiconductors (OSCs) are either inefficient or can only apply some OSCs conditionally, seriously limiting their general applications. Herein, a novel p‐doping mechanism revealed by investigating interactions between dopant trityl tetrakis(pentafluorophenyl) borate (TrTPFB) and poly(3‐hexylthiophene) (P3HT). It found that electrophilic attack cations on...
Polycyclic hydrocarbons with diradical and polyradical characters usually display unique reactivities in ring-cyclization reactions. However, such reactions are rarely used to construct π-extended polycyclic aromatic hydrocarbons. Here, we describe the synthesis of an S-shaped doubly helical singlet diradicaloid compound its facile transformation into unprecedented circumchrysene via a two-stage ring cyclization, which includes: (1) eletrocylization from precursor (2) Scholl reaction. The...
Peroxynitrite (ONOO–) is involved in neurodegenerative, inflammatory, cardiovascular disorders, cancers, and other pathological progress. However, current imaging methods for sensing ONOO– usually suffer from high background/autofluorescence fluorescent probes poor selectivity/short emission wavelength chemiluminescent probes. Herein, we present a novel molecule (oxygen-embedded quinoidal pentacene) responsive to the first time, on basis of which rationally construct near-infrared nanoprobe...
Abstract Functional brain networks require dynamic reconfiguration to support flexible cognitive function. However, the developmental principles shaping network dynamics remain poorly understood. Here, we report longitudinal development of large-scale during childhood and adolescence, its connection with gene expression profiles. Using a multilayer model, show temporally varying modular architecture child networks, higher switching primarily in association cortex lower primary regions. This...
From childhood to adolescence, the structural organization of human brain undergoes dynamic and regionally heterogeneous changes across multiple scales, from synapses macroscale white matter pathways. However, during this period, developmental process multiscale architecture, its association with cortical morphological changes, role in maturation functional remain largely unknown. Here, using two independent multimodal imaging datasets aged 6–14 years, we investigated by constructing an vivo...
A novel photochemical approach for the synthesis of phenanthrene derivatives from linear 3-aryl-N-(arylsulfonyl) propiolamides via a tandem radical Smiles rearrangement/C–S bonding/Mallory reaction is disclosed. The control experiment results and isolation key intermediates give further insight into mechanism. Gram scale using flow reactor demonstrated synthetic potential applications our protocol.
Photoacoustic (PA) imaging as a noninvasive biomedical technology exhibits high spatial resolution and deep tissue penetration for in vivo imaging. In order to fully explore the potential of PA applications, new contrast agents with improved stability efficiency are demand. Herein, we present agent based on an oxygen-embedded quinoidal nonacene chromophore that is self-assembled into nanoparticles (Nano(O-Nonacene)-PEG), assisted by polyethylene glycol (PEG). Notably, photothermal conversion...
Open AccessCCS ChemistryCOMMUNICATION1 Jan 2022Stable Quadruple Helical Tetraradicaloid with Thermally Induced Intramolecular Magnetic Switching Jing Guo, Zhiyu Li, Jun Zhang, Bo Yuan Liang, Yanpei Wang, Sheng Xie, Hoa Phan, Tun Seng Herng, Ding, Jishan Wu, Ben Zhong Tang and Zebing Zeng Guo State Key Laboratory of Chemo/Biosensing Chemometrics, College Chemistry Chemical Engineering/Shenzhen Research Institute, Hunan University, Changsha 410082 , Li Zhang School Materials Engineering, Anhui...
Attention and reading are essential skills for successful schooling in adult life. While previous studies have documented that attention development supports acquisition, whether how learning to read may improve among school-age children the brain structural functional be involved remain unknown. In this prospective longitudinal study, we examined bidirectional predictions between neural mediators of using cross-lagged panel modeling. The results showed better baseline performance...