A5050426677- Advanced Control Systems Optimization
- Process Optimization and Integration
- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Evolutionary Algorithms and Applications
- Metaheuristic Optimization Algorithms Research
- Bioinformatics and Genomic Networks
- Protein Structure and Dynamics
- Crystallization and Solubility Studies
- Maritime Navigation and Safety
- Modeling and Simulation Systems
- Nonlinear Dynamics and Pattern Formation
- Simulation Techniques and Applications
- Neural Networks and Applications
- Coagulation and Flocculation Studies
- Viral Infectious Diseases and Gene Expression in Insects
- thermodynamics and calorimetric analyses
- Bacterial Genetics and Biotechnology
- Model-Driven Software Engineering Techniques
- Protein purification and stability
- Fault Detection and Control Systems
- Advanced Thermodynamics and Statistical Mechanics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Evolution and Genetic Dynamics
- Adaptive Control of Nonlinear Systems
University of New Caledonia
2019-2025
Laboratoire d'Informatique, Signaux et Systèmes de Sophia Antipolis
2002-2016
Département Mathématiques et Informatique Appliquées
2003-2011
Université des Antilles
2008-2010
Max Planck Institute for Dynamics of Complex Technical Systems
2000-2009
Max Planck Society
2000-2009
University of Stuttgart
1996-2007
Centre National de la Recherche Scientifique
2005
Laboratoire de Mathématiques
2005
University Hospital Magdeburg
2004
Abstract Motivation: Molecular biotechnology now makes it possible to build elaborate systems models, but the biology community needs information standards if models are be shared, evaluated and developed cooperatively. Results: We summarize Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks. SBML is software-independent language describing common research in many areas of computational biology, including cell...
Need for software to setup and analyze complex mathematical models cellular systems in a modular way, that also integrates the experimental environment of cells.A computer framework is described which allows building modularly structured using an abstract, general modeling methodology. With this methodology, reusable entities are introduced lead development library within tool ProMot. The simulation Diva used numerical analysis parameter identification models. provides number tools...
Abstract A mathematical model for apical growth, septation, and branching of mycelial microorganisms is presented. The consists two parts: the determinstic part based on fundamental cellular physical mechanisms; it represents kinetics growth hyphal tips septation as well intercalary compartments. In regard to random occurrences branching, stochastic deals with processes, tip directions, outgrowth orientations branches. can explain morphological development mycelia up formation pellets....
Feinberg's chemical reaction network theory (CRNT) connects the structure of a biochemical to qualitative properties corresponding system ordinary differential equations. No information about parameter values is needed. As such, it seems be well suited for application in systems biology, where uncertainty predominant. However, its this area rare. To demonstrate potential benefits from application, different networks representing single layer well-studied mitogen-activated protein kinase...
The simulated moving-bed process (SMB) is used for continuous chromatographic separation in chemical engineering and biotechnology. In the usual operating scheme of SMB processes, parameters, namely, fluid volume flows, are kept constant. this contribution, a new way with flows varied within each switching interval suggested. It shown that solvent consumption can be reduced substantially given feed throughput. Alternatively, purity increased while keeping both throughput
This paper introduces compelling problems of biological systems and signaling networks to show how engineering tools can be applied the analysis cellular machinery. The mechanisms that cells have developed process information are described, decomposition signalling into subsystems is discussed. A novel criterion for defining modules based on absence retroactivity also presented, some simple criteria resulting units introduced. Two examples, two-component MAPK cascade, a more complicated...
Abstract Motivation: In Escherichia coli, the phosphoenolpyruvate: carbohydrate phosphotransferase system acts like a sensory element which is able to measure flux through glycolysis. Since output of sensor, phosphorylated form protein EIIA, connected activity global transcription factor Crp, kinetic and structural properties are important for understanding overall cellular behavior. Results: A family mathematical models presented, varying with respect their degree complexity (number...
Abstract The novel process modeling tool PROMOT supports the object-oriented of chemical processes for simulation environment DIVA. In PROMOT, differential-algebraic models can be built by aggregating structural and behavioral entities that represent topological structure or dynamic steady-state behavior, respectively, investigated processes. Process their may defined either in an language with a graphical user interface. This paper discusses concept, language, knowledge representation...
SUMMARY A method is described for directly observing submerged growth of streptomycetes, which can be easily adapted investigations filamentously growing fungi. The use an image processing system allowed a fast and accurate calculation important morphological parameters. Most the images analysed on‐line. Some results are presented early branching Streptomyces tendae. It seems that mechanisms streptomycetes were same both solid liquid media.