A5071835218- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Hemispheric Asymmetry in Neuroscience
- Advanced MRI Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Motor Control and Adaptation
- Trigeminal Neuralgia and Treatments
- Eating Disorders and Behaviors
- Muscle activation and electromyography studies
- Genetic Neurodegenerative Diseases
- Pain Management and Treatment
- Vagus Nerve Stimulation Research
- Pain Mechanisms and Treatments
- Spinal Dysraphism and Malformations
- Language Development and Disorders
- Neonatal and fetal brain pathology
- Migraine and Headache Studies
Harvard University
2016-2023
Boston Children's Hospital
2016-2023
Boston University
2017-2023
Imaging Center
2023
Boston Children's Museum
2017-2018
Beth Israel Deaconess Medical Center
2016
Lorcaserin is a serotonin 5-hydroxytryptamine 2c receptor agonist effective in treating obesity. Studies rodents have shown that lorcaserin acts the brain to exert its weight-reducing effects, but this has not yet been studied humans. We performed randomized, placebo-controlled, double-blind trial with 48 obese participants and used functional MRI study effects of on brain. Subjects taking had decreased activations attention-related parietal visual cortices response highly palatable food...
Animal and proof-of-principle human studies suggest that cathodal transcranial direct current stimulation may suppress seizures in drug-resistant focal epilepsy. The present study tests the safety, tolerability, effect size of repeated daily epilepsy have not been established, limiting development clinically meaningful interventions.We conducted a 2-center, open-label on 20 participants with medically refractory, epilepsy, aged 9 to 56 years (11 women children younger than18 years). Each...
Low frequency repetitive TMS (rTMS) of a cortical seizure focus is emerging as an antiepileptic treatment. While conventional rTMS stimulators activate only superficial areas, reaching deep epileptic foci, for example in temporal lobe epilepsy (TLE), possible using specially designed H-coils. We report the results young adult with pharmacoresistant bilateral TLE who underwent three courses (of 10, 15, and 30 daily sessions) unilateral over hemisphere from which seizures originated most...
Objectives: A neurophysiologic biomarker for autism spectrum disorder (ASD) is highly desirable and can improve diagnosis, monitoring, assessment of therapeutic response among children with ASD. We investigated the utility continuous theta-burst stimulation (cTBS) applied to motor cortex (M1) as a adolescents high-functioning (HF) ASD compared their age- gender-matched typically developing (TD) controls. also developmental trajectory long-term depression- (LTD-)like plasticity in two groups....
Transcranial magnetic stimulation (TMS) is a method for focal brain that based on the principle of electromagnetic induction where small intracranial electric currents are generated by powerful fluctuating field. Over past three decades, TMS has shown promise in diagnosis, monitoring, and treatment neurological psychiatric disorders adults. However, use children been more limited. We provide brief introduction to technique; common protocols including single-pulse TMS, paired-pulse paired...
Epilepsy is associated with numerous neurodevelopmental disorders. Transcranial magnetic stimulation (TMS) of the motor cortex coupled electromyography (EMG) enables biomarkers that provide measures cortical excitation and inhibition are particularly relevant to epilepsy related The threshold (MT), silent period (CSP), short interval intracortical (SICI), facilitation (ICF), long (LICI) among TMS-derived metrics modulated by antiepileptic drugs. TMS may have a practical role in optimization...
Aim: To assess changes in the developmental trajectory of corticospinal tracts maturation children with hemiplegic cerebral palsy (HCP). Methods: Neuroimaging data were obtained from 36 HCP for both more affected and less hemispheres, and, purposes direct comparison, between groups, 15 typically developing children. With diffusion tensor imaging, we estimated mean fractional anisotropy, axial diffusivity, radial diffusivity tract, parameters indicative factors including myelination axon...
We present a case of preserved corticospinal connectivity in cortical tuber, 10 year-old boy with intractable epilepsy and tuberous sclerosis complex (TSC). The patient had multiple subcortical tubers, one which was located the right central sulcus. In preparation for surgery, motor mapping, by neuronavigated transcranial magnetic stimulation (nTMS) coupled surface electromyography (EMG) performed to locate primary areas. resulting functional map revealed expected left precentral gyrus....
Background: Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a disorder of GABA degradation with use-dependent downregulation postsynaptic A/B receptors. We aim to measure the resulting cortical excitation: inhibition ratio using transcranial magnetic stimulation. Methods: In this single-center observational study, 18 subjects SSADHD and 8 healthy controls underwent Resting motor threshold, silent period, long-interval intracortical were measured in both groups. threshold focal...
Abstract Neuronavigated transcranial magnetic stimulation (nTMS) has emerged as a presurgical language mapping tool distinct from the widely used functional resonance imaging (fMRI). We report fMRI and nTMS language‐mapping results in 19 pediatric‐epilepsy patients compare those to definitive testing by electrical cortical stimulation, Wada test, and/or neuropsychological testing. Most discordant occurred when found right‐hemispheric language. In cases, showed left‐hemispheric or bilateral...
Background Low frequency (≤1 Hz) repetitive transcranial magnetic stimulation (rTMS) has been shown to suppress cortical excitability and is beginning be trialed for the treatment of refractory epilepsy. Purpose As a step toward larger trial, current pilot study was aimed test tolerability safety temporal lobe rTMS using H-coil epilepsy (TLE). Research Design 1800 pulses active or sham were applied 5 days week 2 weeks over affected hemisphere. Results Nine participants enrolled randomized...
Purpose: Motor evoked potential (MEP) amplitude and latency are acquired routinely during neuronavigated transcranial magnetic stimulation, a method of functional mapping the motor cortex before epilepsy surgery. Although MEP is used to generate map, in patients with focal has not been studied systematically. Given that may alter myelination, we tested whether intrinsic hand muscle MEPs obtained from hemisphere containing seizure focus differ collected opposite hemisphere. Methods: Latencies...