A5006276916- Parasites and Host Interactions
- Drug-Induced Hepatotoxicity and Protection
- Ovarian cancer diagnosis and treatment
- Helminth infection and control
- Identification and Quantification in Food
- Fish Biology and Ecology Studies
- Intraperitoneal and Appendiceal Malignancies
- Genetic diversity and population structure
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Microbial Metabolites in Food Biotechnology
- Endometriosis Research and Treatment
- Kruppel-like factors research
- Hippo pathway signaling and YAP/TAZ
- Hepatitis Viruses Studies and Epidemiology
- Nanoparticles: synthesis and applications
- Wnt/β-catenin signaling in development and cancer
- Drug Transport and Resistance Mechanisms
- Graphene and Nanomaterials Applications
- Macrophage Migration Inhibitory Factor
- Phytase and its Applications
- Liver physiology and pathology
- Circular RNAs in diseases
- Insect and Pesticide Research
- Parasite Biology and Host Interactions
Shaukat Khanum Memorial Cancer Hospital and Research Center
2024
Allama Iqbal Open University
2024
Jamia Millia Islamia
2015-2023
National Bureau of Fish Genetic Resources
2010-2012
Theodor Bilharz Research Institute
1981-1986
Vanderbilt University Medical Center
1986
Health questionnaires and parasitologic examinations of urine stool were evaluated from a stratified random sample 89,180 individuals 17,172 households in 251 rural communities 9 governorates Egypt to investigate the prevalence of, risk factors for, changing pattern infection with Schistosoma sp. Egypt. A subset, every fifth household, or 18,600 subjects, had physical ultrasound for morbidity. Prevalence S. haematobium 4 Upper which it is endemic ranged 4.8% 13.7% averaged 7.8%. The...
Objective: To determine the impact of delay between neoadjuvant chemotherapy and cytoreductive surgery on progression-free survival overall in ovarian cancer cases. Method: The retrospective study was conducted at Department Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore, Pakistan, comprised data from January 2019 to 2022 women diagnosed with stage III high-grade serous who received underwent subsequent interval debulking surgery. patients were...
Immune responsiveness of schistosomiasis patients was assayed longitudinally, before and for two years after chemotherapeutic treatment with praziquantel, by in vitro peripheral blood mononuclear cell (PBMN) proliferation upon exposure to phytohaemagglutinin (PHA), or soluble schistosomal antigenic preparations from eggs (SEA), adult worms (SWAP) cercariae (CAP). Parallel faecal urine examinations documented the infection status during this time. Treatment resulted substantially increased...
Background: Forkhead box "O" one which is member of family transcription factors known to play key role in different physiological processes including cell cycle arrest, autophagy, and apoptosis. FOXO1 defined tumor suppressive various malignancies breast cancer its Dysregulation frequently reported. However, the evaluation promoter methylation expression at mRNA protein level stages association with clinical parameters still not studied. Therefore, for better understanding cancer, our study...
Background FOXO3, a member of the FOX transcription factor family, is frequently described as being deregulated in cancer. Additionally, notable role FOXO3 can be easily recognized process ageing and survival. Even though various studies have been done to acknowledge tumour-suppressive or oncogenic cancer, still there exist lack understanding terms cancer prognosis treatment. Therefore, provide better insight, our study aims evaluate function breast Indian female patients. We examined...
In order to determine whether infection with S. mansoni is related a higher rate of HBV and/or probability HBsAg chronic carriage, population based survey was carried out in Egypt which markers were studied 67 subjects heavy long-lasting infection. Controls no or low grade individually matched the cases for age, sex and village origin. 41.8% 37.3% controls showed marker The prevalence anti-HBc alone 4.5% 7.5% controls. For anti-HBs figures 53.7% 55.2% respectively. No positive HBsAg. These...
The primary objectives of this study, carried out in Qalyubia Governorate Egypt (south-central Nile Delta), were to continue tracking historical trends infection prevalence Schistosoma mansoni and S. haematobium, determine whether satellites (ezbas) mother villages differed significantly with respect schistosomiasis transmission, asses schistosomiasis-induced morbidity on a population basis using ultrasonography. Our study revealed that haematobium has virtually disappeared from governorate,...
The effect of histamine on cell-mediated immune responses chronic schistosomiasis patients was tested by peripheral blood mononuclear cell (PBMN) reactions to phytohemagglutinin-P (PHA) and soluble schistosomal antigenic preparations derived from eggs (SEA) or adult worms (SWAP). PBMN PHA were suppressed exogenous (10(-5)M), the addition cimetidine (CIM) (10(-4)M), an H2-receptor antagonist, reversed this suppressive effect. Histamine primarily suboptimal optimal concentrations. Exogenous...
Abstract Nanomaterials have become integral in various aspects of agricultural practices, including the development nano-fertilizers for optimized crop nutrition. This study explores application green-synthesized iron (Fe) and molybdenum (Mo) nanoparticles, as well their composites, using a guava leaf extract (GLE). The focus is on assessing impact nitrogen fixation growth tomato plants ( Solanum lycopersicum ). nanoparticles were characterized through Fourier Transform Infrared...
<h3>Introduction/Background</h3> It is very controversial whether routine appendectomy should be performed as a part of surgery for mucinous borderline ovarian tumors (mBOTs) and invasive tumours (IMOT) the exact magnitude benefits are unclear. So current study has been conducted to determine frequency appendiceal involvement in patients who undergo mBOTs associated morbidity recurrence after surgery. <h3>Methodology</h3> Hospital database was searched all from Jan 2008 Dec 2022, whose final...
<h3>Introduction/Background</h3> Advanced stage ovarian cancer treatment includes chemotherapy and surgical debulking of the disease. The introduction neoadjuvant for reduction tumor load followed by interval surgery has shown to have proven survival benefit.3 This study helps elucidate whether a delay more than 6 weeks between an impact on progression free survival. <h3>Methodology</h3> All women diagnosed with III high-grade serous who received underwent subsequent from January 2019 2022...
Background: It is very controversial whether appendectomy should be performed as a routine part of the staging procedure for mucinous borderline ovarian tumours (mBOTs) or not, involvement appendix in women undergoing surgery mBOTs and exact magnitude benefit are unclear. This study was conducted to determine frequency appendiceal patients morbidity associated with evaluate recurrence-free survival after surgery. Methods: retrospective cohort at cancer centre from January 2008 December 2022...
Summary The peripheral blood mononuclear cell (PBMN) proliferative responses of cells from patients with schistosomiasis were studied in the presence and absence indomethacin culture medium. PBMN cultures exposed to antigenic extracts either adult S. mansoni worms (SWAP) or cercariae (CAP), assayed for incorporation tritiated thymidine. More than 70% 48 SWAP 40 CAP, not substantially effected by addition cultures. remainder (less 30%) was augmented more 50% comprise a group which gave...
Natural killer (NK) activity was assayed in peripheral blood mononuclear cells of patients with schistosomiasis, following treatment, and uninfected control subjects. The patient populations were from villages the Qalyub Province, Egypt around Belo Horizonte , Brazil. NK by cytotoxicity 51Cr-labelled K562 target tumor cells. In neither infected population significant alterations normal levels found percent per 10(6) cells, or lytic units that expressed 25% cytotoxicity. Likewise, prior...
Lymphocyte blastogenesis during chronic schistosomiasis has been evaluated previously by either whole blood or peripheral mononuclear cell (PBMN) culture techniques. These two methods were compared in the present study. Blastogenesis to mitogen phytohaemagglutinin was greater cultures at time assayed. Substantial antigen-induced lymphocyte transformation elicited both systems using cells from uninfected patients. However, patients' responses schistosome-derived antigenic preparations as...