A5001589062- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Dietary Effects on Health
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Sports injuries and prevention
- Winter Sports Injuries and Performance
- Injury Epidemiology and Prevention
- Cardiovascular Effects of Exercise
- Sports Performance and Training
- Genetic factors in colorectal cancer
- Congenital Diaphragmatic Hernia Studies
- Pleural and Pulmonary Diseases
- Single-cell and spatial transcriptomics
- Renal cell carcinoma treatment
- Autopsy Techniques and Outcomes
- Medical Imaging Techniques and Applications
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cryospheric studies and observations
- Ferroptosis and cancer prognosis
Shanghai Public Security Bureau
2024
Australian Catholic University
2023-2024
Peking University People's Hospital
2020-2023
Peking University
2020-2023
Abstract Background The feasibility of DNA methylation-based assays in detecting minimal residual disease (MRD) and postoperative monitoring remains unestablished. We aim to investigate the dynamic characteristics cancer-related methylation signals MRD detection surgical lung cancer patients. Methods Matched tumor, tumor-adjacent tissues, longitudinal blood samples from a cohort (MEDAL) were analyzed by ultra-deep targeted sequencing bisulfite sequencing. A tumor-informed (timMRD) was...
Nodule evaluation is challenging and critical to diagnose multiple pulmonary nodules (MPNs). We aimed develop validate a machine learning-based model estimate the malignant probability of MPNs guide decision-making.A boosted ensemble algorithm (XGBoost) was used predict malignancy using clinicoradiologic variables 1,739 from 520 patients with at Chinese center. The (PKU-M model) trained 10-fold cross-validation in which hyperparameters were selected fine-tuned. validated compared solitary...
Stage I non-small cell lung cancer (NSCLC) presents diverse outcomes. To identify molecular features leading to tumor recurrence in early-stage NSCLC, we perform multiregional whole-exome sequencing (WES), RNA sequencing, and plasma-targeted circulating DNA (ctDNA) detection analysis between recurrent recurrent-free stage NSCLC patients (CHN-P cohort) who had undergone R0 resection with a median 5-year follow-up time. Integrated indicates that the multidimensional clinical genomic model can...
Over the years, multiple models have been developed for evaluation of pulmonary nodules (PNs). This study aimed to comprehensively investigate clinical estimating malignancy probability in patients with PNs.
Abstract Background: Patient-specific flexible gene panels designed based on whole-exome sequencing (WES) of resected tumor tissues is a promising strategy for ctDNA-based detection molecular residual disease (MRD) in early-stage NSCLC. Flexible could potentially overcome the limitations fixed by incorporating more unique genomic regions that might be absent panels; however, no study has reported head-to-head comparison these two approaches postoperative monitoring. In this study, we...
This study aims to compare the clinical and pathological characteristics between patients undergoing surgery for extremely multiple ground-glass nodules (GGNs) those single GGN.We defined GGNs as follows: (i) number of ≥3, (ii) GGN diameter 3 30 mm, (iii) no less than three that were surgically removed pathologically diagnosed. Patients with who underwent at same time retrospectively analyzed. The divided into groups according nodules: exceedingly (EMN) group (>10), highly (HMN) (three 10),...
<h3>Background</h3> Hamstring strain injuries (HSIs) occur frequently in Australian Football. <h3>Objective</h3> To determine which factors were most predictive of HSIs during different stages competition. <h3>Design</h3> Prospective cohort <h3>Setting</h3> Professional Football <h3>Participants</h3> Male professional Footballers (n=311) <h3>Assessment Risk Factors</h3> Eccentric knee flexor strength and BFlh architecture assessed at the start end pre-season middle competitive season....
Abstract Background: As traditional autopsy rates decline, the importance of forensic imaging, particularly postmortem computed tomography (PMCT), grows for non-invasive cause death determination and evidence collection in legal investigations, with unique considerations required frozen corpses due to lack systematic imaging characteristic studies. Aims Objectives: This study aims fill gap current knowledge by systematically analyzing PMCT characteristics corpses. Materials Methods: utilized...
ABSTRACT Background/aim This study aimed to determine which factors were most predictive of hamstring strain injury (HSI) during different stages the competition in professional Australian Football. Methods Across two competitive seasons, eccentric knee flexor strength and biceps femoris long head architecture 311 Football players (455 player seasons) assessed at start end preseason middle season. Details any prospective HSI collated by medical staff participating teams. Multiple logistic...
Abstract Background: Through parallel testing and comparison of personalized fixed panel minimal residual disease (MRD) assays, to establish the best technique application strategy dynamic MRD detection for prognosis prediction assessment among non-small cell lung cancer (NSCLC) patients. Method: We analyzed 760 plasma samples from prospectively enrolled 181 patients with NSCLC recruited MEDAL study (NCT03634826), stage I (63%), II (19%) III (18%). 80% were adenocarcinomas. Plasma collected...
Abstract Chest LDCT provides an effective approach for lung cancer screening, yet has been found to generate a large number of false positives during practice due excessive diagnosis pulmonary lesions indeterminate clinical significance. In this study, we performed comprehensive genetic and epigenetic profiling cfDNA from patients individuals bearing benign lesions, using ultra-deep targeted sequencing bisulfite sequencing. We that mutation profile alone relatively limited power in...
With the dramatically increasing detection rate of ground-glass nodules (GGN), exact understanding and treatment strategy them has become hottest issue currently. More more studies have begun to explore underlying mechanisms their indolent characteristics favorable prognosis from perspectives molecular evolution immune microenvironment. GGN different dominating gene mutations at evolutional stages. The pure a lower tumor mutation burden genomic instability, while gradually evolutionary...