A5003936887- nanoparticles nucleation surface interactions
- Advanced Chemical Physics Studies
- Catalytic Processes in Materials Science
- Theoretical and Computational Physics
- Lipid Membrane Structure and Behavior
- Spectroscopy and Quantum Chemical Studies
- Catalysis and Oxidation Reactions
- Gene Regulatory Network Analysis
- Material Dynamics and Properties
- Advanced Thermodynamics and Statistical Mechanics
- Force Microscopy Techniques and Applications
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Electrocatalysts for Energy Conversion
- Molecular Junctions and Nanostructures
- Nanopore and Nanochannel Transport Studies
- Nonlinear Dynamics and Pattern Formation
- Protein Structure and Dynamics
- Hydrogen Storage and Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Bacteriophages and microbial interactions
- Acoustic Wave Resonator Technologies
- Polymer Surface Interaction Studies
- stochastic dynamics and bifurcation
- Plasmonic and Surface Plasmon Research
Boreskov Institute of Catalysis
2016-2025
Chalmers University of Technology
2014-2023
Nanyang Technological University
2013-2017
Taras Shevchenko National University of Kyiv
2016
Astronomical Observatory
2016
Russian Academy of Sciences
2006-2015
Stevens Institute of Technology
2009
Hokkaido University
2004-2007
Aarhus University
2006
Western University
1994-2000
Using quartz crystal microbalance with dissipation and ellipsometry, we show that during adsorption of fibrinogen on evaporated tantalum films the saturation uptake increases increasing root-mean-square roughness (from 2.0 to 32.9 nm) beyond accompanying increase in surface area. This is attributed a change geometrical arrangement molecules surface. For comparison, nearly globular protein, bovine serum albumin, was studied as well. In this case, less influenced by roughness. Simple Monte...
Using a combination of the quartz crystal microbalance and surface plasmon resonance techniques, we have studied spontaneous formation supported lipid bilayers from small ( $\ensuremath{\sim}25\mathrm{nm}$) unilamellar vesicles. Together these experimental methods measure amount adsorbed on water trapped by lipid. With this approach, have, for first time, been able to observe in detail progression adsorption intact vesicles rupture bilayer formation. Monte Carlo simulations reproduce data.
Planar lipid bilayers on solid supports mimic the fundamental structure of biological membranes and can be investigated using a wide range surface-sensitive techniques. Despite these advantages, planar bilayer fabrication is challenging, there are no simple universal methods to form such diverse material substrates. One novel recently proposed proven silicon dioxide involves deposition in organic solvent exchange influence phase adsorbed lipids. To scrutinize specifics this solvent-assisted...
Employing rationally designed model systems with precise atom-by-atom particle size control, we demonstrate by means of combining noninvasive in situ indirect nanoplasmonic sensing and ex scanning transmission electron microscopy that monomodal size-selected platinum cluster catalysts on different supports exhibit remarkable intrinsic sintering resistance even under reaction conditions. The observed stability is related to suppression Ostwald ripening elimination its main driving force via...
Exosomes are cell-secreted nanometer-sized extracellular vesicles that have been reported to play an important role in intercellular communication. They also considered potential diagnostic markers for various health disorders, and intense investigations presently directed toward their use as carriers drug-delivery gene-therapy applications. This has generated a growing need sensitive methods capable of accurately specifically determining the concentration exosomes complex biological fluids....
Using a new indirect nanoplasmonic sensing method with subsecond resolution, we have studied hydriding and dehydriding kinetics of Pd nanoparticles in the size range 1.8--5.4 nm. Strong particle-size effects are observed. The scaling time scales satisfies power power-exponential laws. former (with an exponent 2.9) is perfect agreement Monte Carlo simulations diffusion-controlled kinetics. latter explained by effect surface tension on hydrogen desorption from layer. approach generalizable to...
Hydride-forming metal nanoparticles sustaining localized surface plasmon resonance have emerged as prototypical material to study the fundamentals of hydrogen-induced phase transformations. They also been proposed signal transducers in next-generation hydrogen sensors. However, despite high current interest sorption by nanomaterials general and such sensors particular, correlations between nanoparticle size, shape, composition, amount absorbed, obtained optical response not systematically...
Lipid nanoparticles (LNPs) have emerged as potent carriers for mRNA delivery, but several challenges remain before this approach can offer broad clinical translation of therapeutics. To improve their efficacy, a better understanding is required regarding how LNPs are trapped and processed at the anionic endosomal membrane prior to release. We used surface-sensitive fluorescence microscopy with single LNP resolution investigate pH dependency binding kinetics ionizable lipid-containing...
The adhesion of lipid vesicles to solid supports represents an important step in the molecular self-assembly model membrane platforms. A wide range experimental parameters are involved controlling this process, including substrate material and topology, composition, vesicle size, solution pH, ionic strength, osmotic pressure. At present, it is not well understood how magnitude direction pressure exerted on a influence corresponding adsorption kinetics. In work, using quartz crystal...
As a simple and efficient technique, the solvent-assisted lipid bilayer (SALB) formation method offers versatile approach to fabricating planar on solid supports. Corresponding mechanistic aspects role of various governing parameters remain, however, be better understood. Herein, we first scrutinized effect concentration (0.01 5 mg/mL) solvent type (isopropanol, n-propanol, or ethanol) SALB silicon oxide in order identify optimal conditions for this process. The obtained fluid-phase layers...
Accurate concentration determination of subpopulations extracellular vesicles (EVs), such as exosomes, is importance both in the context understanding their fundamental biological role and potentially using them disease biomarkers. In principle, this can be achieved by measuring rate diffusion-limited mass uptake to a sensor surface modified with receptor designed only bind subpopulation interest. However, significant error introduced if targeted EV has size, thus hydrodynamic diffusion...
The fate of adsorbed lipid vesicles on solid supports depends numerous experimental parameters and typically results in the formation a supported bilayer (SLB) or an vesicle layer. One poorly understood questions relates to how divalent cations appear promote SLB some cases. complexity arises from multiple ways which affect vesicle–substrate vesicle–vesicle interactions as well properties. These are reflected, e.g., degree deformation (if they do not rupture). It is, however, experimentally...
Advancement in the understanding of biomolecular interactions has benefited greatly from development surface-sensitive bioanalytical sensors. To further increase their broad impact, significant efforts are presently being made to enable label-free and specific biomolecule detection with high sensitivity, allowing for quantitative interpretation general applicability at low cost. In this work, we have addressed challenge by developing a waveguide chip consisting flat silica core embedded...
Macromolecular association commonly occurs via dynamic engagement of multiple weak bonds referred to as multivalent interactions. The distribution the number bonds, combined with their strong influence on residence time, makes it very demanding quantify this type interaction. To address challenge in context virology, we mimicked virion a cell membrane by attaching lipid vesicles (100 nm diameter) supported bilayer multiple, identical cholesterol-based DNA linker molecules, each mimicking an...
Abstract Grain boundaries separate crystallites in solids and influence material properties, as widely documented for bulk materials. In nanomaterials, however, investigations of grain are very challenging just beginning. Here, we report the systematic mapping role hydrogenation phase transformation individual Pd nanoparticles. Employing multichannel single-particle plasmonic nanospectroscopy, observe large variation particle-specific hydride-formation pressure, which is absent hydride...