A5049231016- Thyroid Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Hormonal Regulation and Hypertension
- Pancreatic and Hepatic Oncology Research
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Gallbladder and Bile Duct Disorders
- Pituitary Gland Disorders and Treatments
- Global Cancer Incidence and Screening
- Healthcare Policy and Management
- Thyroid and Parathyroid Surgery
- Radiation Dose and Imaging
- Dysphagia Assessment and Management
- Polyomavirus and related diseases
- Wnt/β-catenin signaling in development and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Meningioma and schwannoma management
- Ovarian cancer diagnosis and treatment
- Multiple and Secondary Primary Cancers
- Hippo pathway signaling and YAP/TAZ
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
Cornell University
2020-2024
Weill Cornell Medicine
2021-2024
New York Hospital Queens
2020-2022
Presbyterian Hospital
2020-2022
NewYork–Presbyterian Hospital
2020-2022
Objective: To quantify the contribution of key steps in antireflux surgery on compliance EGJ. Background: The lower esophageal sphincter and crural diaphragm constitute intrinsic extrinsic sphincters EGJ, respectively. Interventions to treat reflux attempt restore integrity However, there are limited data relative critical during procedures functional Methods: Primary was performed 100 consecutive patients with pathologic reflux. Intraoperative EGJ measurements including distensibility index...
Pancreatic neuroendocrine tumors (PNETs) are malignancies arising from the islets of Langerhans. Therapeutic options limited for over 50% patients who present with metastatic disease. We aimed to identify mechanisms remodel PNET tumor microenvironment (TME) ultimately enhance susceptibility immunotherapy. The TMEs localized and PNETs were investigated using an approach that combines RNA-Seq, cancer T cell profiling, pharmacologic perturbations. RNA-Seq analysis indicated primary showed...
Adrenal venous sampling is recommended prior to adrenalectomy for all patients with hyperaldosteronism; however, cross-sectional imaging resolution continues improve, while the procedure remains invasive and technically difficult. Therefore, certain may benefit from advancing straight surgery.To determine whether clinical biochemical varied primary aldosteronism unilateral adenomas who underwent adrenal vs those proceeded surgery based on alone.Retrospective, international cohort study of...
Genetic alterations in RET lead to activation of ERK and AKT signaling are associated with hereditary sporadic thyroid cancer lung cancer. Highly selective inhibitors have recently entered clinical use after demonstrating efficacy treating patients diverse tumor types harboring gene rearrangements or activating mutations. In order understand resistance mechanisms arising treatment inhibitors, we performed a comprehensive molecular genomic analysis patient RET-rearranged Using combination...
Introduction: Pediatric papillary thyroid carcinomas (PTCs) are more invasive than adult PTCs. No large, contemporary cohort study has been conducted to determine whether younger children at higher risk for advanced disease presentation compared adolescents. We aimed describe pediatric PTC and contextualize its characteristics with a young comparison cohort. Methods: The National Cancer Database was interrogated PTCs diagnosed between 2004 2017. Clinical variables were prepubertal (≤10 years...
Anaplastic thyroid cancer (ATC) is a rare with poor prognosis and few treatment options. The objective of this study was to investigate new immune-associated therapeutic targets by identifying ATC-derived, human leukocyte antigen (HLA) class II-presenting peptides. One protein that generated multiple peptides in ATC chondroitin sulfate-proteoglycan-4 (CSPG4), transmembrane proteoglycan increased expression aggressive cancers, but not yet investigated ATC.
Introduction: Malignant struma ovarii (MSO) is a rare thyroid cancer arising within an ovarian teratoma. While surgical excision of the primary tumor widely accepted as standard care, recommendations for adjuvant treatment MSO-whether or not to administer radioactive iodine (RAI)-are based largely on case reports and remain debated. In this study, we aimed propose risk stratification analyze RAI utilization patterns in MSO cases. Methods: The National Cancer Database (NCDB) was queried...
The significance of low mitotic activity in papillary thyroid cancer (PTC) is largely undefined.