A5022066893- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Pituitary Gland Disorders and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Intraocular Surgery and Lenses
- Facial Trauma and Fracture Management
- Ocular Infections and Treatments
- Ocular Oncology and Treatments
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Nasolacrimal Duct Obstruction Treatments
- Vasculitis and related conditions
- Histiocytic Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Vascular Malformations and Hemangiomas
- Renal Diseases and Glomerulopathies
- Ocular Disorders and Treatments
- Corneal surgery and disorders
- Meningioma and schwannoma management
- Inflammatory Myopathies and Dermatomyositis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sarcoidosis and Beryllium Toxicity Research
- IgG4-Related and Inflammatory Diseases
Massachusetts Eye and Ear Infirmary
2018-2025
Harvard University
2019-2025
Brown University
2025
Olympus (Germany)
2023
Medtronic (United States)
2023
Stryker (United States)
2023
University of Puerto Rico at Carolina
2023
Ophthalmology Associates (United States)
2020
Florida International University
2011
A 73-year-old male with a history of incidentally diagnosed Paget disease bone affecting the skull and left orbit 2 years prior presented 3 months vision loss, proptosis, periorbital swelling OS. Examination showed best-corrected Snellen visual acuity 20/150 in affected eye, intact motility, 7 mm relative significant dilated tortuous “corkscrew” conjunctival vessels, serous choroidal retinal detachments, optic nerve hyperemia, venous tortuosity dilation. Although bony lesions were stable...
High-pressure diesel soft tissue injuries are uncommon, especially in the orbit. These can initially have a deceivingly benign clinical appearance and may radiographically mimic emphysema but rapidly progress with vision-threatening outcomes; cases of complete vision loss eye been reported. Early diagnosis intervention essential to minimize chemical injury tissues vital structures. We present case severe from compressed orbit, face, neck requiring multidisciplinary management, serial...
Giant cell arteritis (GCA) is an age-related vasculitis. Prior studies have identified association between GCA and hematologic malignancies (HMs). How the presence of somatic mutations that drive development HMs, or clonal hematopoiesis (CH), may influence clinical outcomes in not well understood.
Purpose: This study analyzed the degree and timing of proptosis regression after teprotumumab therapy. Methods: A retrospective all patients who completed 8 infusions at 1 institution from January 1, 2020 to December 31, 2022. Change in was assessed millimeters percentages compared with immediate post-treatment pretreatment proptosis. Results: Of 119 data (mean follow-up 10.56 months, range: 3.05–25.08), 208 (87.39%) eyes 110 had initial improvement. 78 multiple visits, 102 (65.38%) 59...
To report two cases of thyroid eye disease (TED) associated compressive optic neuropathy (CON) that resolved after treatment with teprotumumab.Two patients presented active TED resulting in mild CON the typical corresponding visual field (VF) defects. Both were initiated on intravenous (IV) corticosteroid therapy but despite had persistent VF then treated teprotumumab and demonstrated marked clinical improvement complete resolution TED-CON defects early their infusion course.These suggest...
To assess optic nerve head (ONH) and peripapillary microvasculature in primary open-angle glaucoma (POAG) of mild to moderate severity using swept-source optical coherence tomography angiography (OCTA).In a cross-sectional study, OCTA images were analyzed for 1 eye from each 30 POAG patients with glaucomatous Humphrey visual field loss 16 controls. The anatomic boundary ONH was manually delineated based on Bruch's membrane opening large vessels removed en face measure vessel density (VD) the...
Purpose Despite the high prevalence, treatment challenges, and significant impact of eyelid retraction on vision quality life among patients with thyroid eye disease, effects teprotumumab are not fully understood. This study evaluated change in upper position after teprotumumab.
Reshef, Edith R. M.D.; Marsiglia, Marcela M.D., Ph.D.; Bouhadjer, Karim; Chiou, Carolina A. O’Brien-Coon, Devin M.S.E.; Reinshagen, Katherine L. Freitag, Suzanne K. M.D. Author Information
Disseminated intravascular coagulation (DIC) is characterized by abnormal activation of the cascade, which leads to simultaneous hypercoagulation and excessive bleeding. While it typically occurs in systemic diseases, such as infection, inflammation, obstetric complications, malignancy, can rarely manifest postoperatively. This case report describes a patient who presented with prolonged, refractory bleeding after ectropion repair via lateral tarsal strip procedure. Due inability control...
Purpose: To compare regression rates, characteristics, and surgical outcomes of thyroid eye disease patients who underwent orbit, strabismus, or eyelid surgery at various times during after teprotumumab treatment. Design: Multicenter, retrospective, observational cohort study. Participants: Adult (age >18) with a minimum 4 infusions treatment for had Methods: Two groups were formed based on timing: group 1 (G1) (<180 days since last infusion) 2 (G2) (≥180 infusion). Main Outcome...
Purpose: To quantify changes in extraocular muscle (EOM) cross-sectional areas (CSA) on orbital imaging patients with thyroid eye disease before and after teprotumumab treatment, assess for correlation clinical outcomes. Methods: This retrospective study included treated who had pre- post-treatment CT imaging. Reformatted oblique coronal images were created each orbit a plane perpendicular to the optic nerve. EOM CSA measurements performed by 2 radiographic reviewers averaged. Primary...
ABSTRACTABSTRACTPurpose Utilization of antibiotics for endoscopic dacryocystorhinostomy (endo-DCR) is largely dependent on individual surgeon preference. This study aimed to investigate prescribing practices pre-, peri-, and postoperative effects infection rates in patients who underwent endo-DCR.Methods A retrospective chart review institutional data at two academic centers endo-DCR cases from 2015–2020 was performed. Postoperative received antibiotics, individually or combination, those...
To determine the clinical relevance of prelaminar wedge defects (PLWDs) detected by swept-source optical coherence tomography (SS-OCT) in primary open-angle glaucoma (POAG).In this retrospective case-control study, PLWDs were defined as triangular-shaped at surface optic nerve tissue, not adjacent to blood vessels, present on cross-sectional SS-OCT scans. Two observers masked diagnosis independently reviewed scans detect and lamina cribrosa defects. History disc hemorrhage, occurring within...
FIGA 55-year-old female presented with 1 to 2 years of progressive, bilateral eyelid hyperpigmentation. She denied topical prostaglandin use or prior surgery. Five presentation, she was diagnosed hemochromatosis and found have complex heterozygosity the homeostatic iron regulator gene in setting elevated ferritin liver hemosiderosis on MRI. Two after her diagnosis, noted a positive antinuclear antibodies leukopenia epicondylar tendinosis started hydroxychloroquine for suspected systemic...
A 62-year-old male was referred for evaluation of a painless right lower-eyelid lesion noted during routine glaucoma follow-up. The had been present 3 years with slow, gradual enlargement. What would you do next?
Two cases are described of necrotizing Sweet syndrome (nSS), a rare variant acute febrile neutrophilic dermatosis that mimics soft tissue infections. A 74-year-old female with myelodysplastic (MDS) presented isolated periorbital nSS closely mimicked fasciitis (NF); she displayed pathergy to debridement, was exquisitely responsive corticosteroids, and underwent successful first-stage reconstruction the eyelid full-thickness skin grafting. second 40-year-old patient relapsed myelogenous...
The authors describe the clinical, histologic, and serologic findings of a patient with necrotizing myositis extraocular muscles in setting antisynthetase syndrome, as well subsequent management. This is first case literature systemic to have associated ophthalmic findings.
Ocular melanocytosis is a well-established risk factor for choroidal melanomas but, despite its reported associations in the literature, it infrequently discussed relation to orbital melanomas. The authors describe teenage patient with ocular who presented an asymptomatic ipsilateral right mass associated lateral rectus muscle. An exploratory orbitotomy revealed lesion lightly adherent underlying sclera. Histopathology demonstrated markedly atypical epithelioid melanocytic proliferation,...
A 78-year-old man presented with acute-onset left temporal pain, eyelid swelling, and double vision. Computed tomography (CT) demonstrated a sphenoid wing mass extra-osseous intra-orbital intracranial extension, thought to be typical meningioma by the primary team. The patient was admitted for an urgent craniotomy, which planned following day. However, upon consultation ophthalmic plastic surgery, concern raised alternative diagnosis given atypical timeline, inflammatory changes,...