A5102923780- Epigenetics and DNA Methylation
- Childhood Cancer Survivors' Quality of Life
- Cancer-related molecular mechanisms research
- Eating Disorders and Behaviors
- MicroRNA in disease regulation
- Health Systems, Economic Evaluations, Quality of Life
- Cancer survivorship and care
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Family Support in Illness
- Steroid Chemistry and Biochemistry
- Psychological Well-being and Life Satisfaction
- Pancreatic function and diabetes
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Cardiac Health and Mental Health
- Mindfulness and Compassion Interventions
- Pediatric Pain Management Techniques
- Liver Disease Diagnosis and Treatment
- Plant-based Medicinal Research
- Protein Degradation and Inhibitors
- Gastrointestinal Tumor Research and Treatment
- Hepatitis B Virus Studies
- Healthcare professionals’ stress and burnout
- Biochemical Acid Research Studies
Wenzhou Medical University
2024-2025
Tianjin Chest Hospital
2012-2024
Tianjin University
2023-2024
Tianjin Medical University
2024
Broward College
2024
Huazhong University of Science and Technology
2024
Wuhan University
2015-2023
Renmin Hospital of Wuhan University
2023
Sun Yat-sen University
2020-2022
West China Hospital of Sichuan University
2021
Fitness to maintain an ideal body shape is becoming increasingly popular among college students. However, it also leads many mental health issues. This study explores the pathways through which negative image affects depression in It examines possible means of implementing interventions populations mediating roles self-efficacy and physical activity, moderating role social support. The present employed a convenience sampling method collect data from 600 university students using Body Image...
Epigenetic regulation has emerged to be the critical steps for tumorigenesis and metastasis. Multiple histone methyltransferase demethylase have been implicated as tumor suppressors or oncogenes recently. But key epigenomic events in cancer cell transformation still remain poorly understood. A breast model was established via stably expressing three primary epithelial cells. Chromatin immunoprecipitation followed by next-generation sequencing of methylations performed determine epigenetic...
Residents' Health is crucial for the effective implementation of "Healthy China 2030" strategy and sustainable development society. However, there still significant room advancement in academic discussions on ensuring residents' health. This study aims to explore relationship between social mobility perception expectation self-rated health, further mediating role subjective well-being this, moderating physical exercise, provide reference more targeted health policies. Based data collected...
Transcription regulation emerged to be one of the key mechanisms in regulating autophagy. Inhibitors H3K9 methylation activates expression LC3B, as well other autophagy-related genes, and promotes autophagy process. However, detailed regulated by nuclear factors remain elusive. In this study, we performed a drug screen SMYD2-/- cells discovered that SMYD2 deficiency enhanced cell death induced BIX01294, an inhibitor histone methylation. BIX-01294 induces accumulation LC3 II death, but not...
Coronary atherosclerosis (CAS) is a major cause of cardiovascular disease. Long non-coding RNAs (lncRNAs) have been implicated as novel biomarkers in coronary artery disease (CAD). APOA1 antisense RNA (APOA1-AS) was proven to show high expression during atherosclerotic development, but no report has uncovered the detailed mechanism APOA1-AS CAS. Thus, this paper aims explore role Vascular smooth muscle cells (VSMCs) were treated with oxidized low-density lipoprotein (ox-LDL) mimic...
Oxidative stress-induced mitochondrial damage is the major cause of cardiomyocyte dysfunction. Therefore, maintenance function, which regulated by quality control (MQC), necessary for homeostasis. This study aimed to explore underlying mechanisms N-acetylcysteine (NAC) function and its relationship with MQC.
Objectives To compare health-related quality of life (HRQoL) between patients with stable angina and the general population in China to examine factors associated HRQoL among angina. Methods A cross-sectional survey recruited from 4 hospitals (n = 411) 3 Physical Examination Centers 549) was conducted July December, 2011 two large cities, Tianjin Chengdu. assessed using EQ-5D, EQ-VAS, SF-6D instruments. The health status specific Seattle Angina Questionnaire (SAQ). Information on...
Abstract MLL3 is a histone H3K4 methyltransferase that frequently mutated in cancer, but the underlying molecular mechanisms remain elusive. Here, we found depletion by CRISPR/sgRNA significantly enhanced cell migration, did not elevate proliferation rate of cancer cells. Through RNA-Seq and ChIP-Seq approaches, identified TNS3 as potential target gene for MLL3. caused downregulation H3K4me1 H3K27ac on an enhancer ~ 7 kb ahead TNS3. 3C assay indicated interacts with promoter repression...
Acute cardiac dysfunction caused by stroke-heart syndrome (SHS) is the second leading cause of stroke-related death. The inflammatory response plays a significant role in pathophysiological process damage. However, mechanisms underlying brain–heart interaction are poorly understood. Therefore, we aimed to analysis immunological characterization and identify inflammation therapeutic targets SHS. We analyzed gene expression data heart tissue 24 hours after induction ischemia stoke MCAO or sham...
To use H9c2 cardiomyocytes to establish a diabetic cardiomyopathic model by exposing these cells high glucose (HG), followed treating them with melatonin (MEL) or plasmid vectors overexpressing FUN14 Domain Containing 1 (FUNDC1).
Objective To examine the dietary behaviours, physical activity (PA) and quality of life (QoL) childhood cancer survivors (CCS) in Mainland China explore relationships between these behaviours QoL. Methods This cross-sectional study recruited 181 CCS from three Grade-A tertiary hospitals Guangzhou. Survivors completed questionnaires assessing their PA Results Only 2.2%, 7.7% 2.2% reported frequent soft drinks, sugar fast food intake, which were lower compared to Western studies. Most (72.9%)...
<title>Abstract</title> Background Fitness to maintain an ideal body shape is becoming increasingly popular among college students. However, it also leads many mental health issues. This study explores the pathways through which negative image affects depression in It examines possible means of implementing interventions populations mediating roles self-efficacy and physical activity, moderating role social support. Method The present employed a convenience sampling method collect data from...
Abstract Background The fear of pain (FOP) and avoidance belief (FAB) play a crucial role in the occurrence development chronic pain. However, dynamics these factors postsurgical appear to differ, with FOP often learned from others rather than directly caused by painful experiences. Psychological resilience refers an individual’s capacity adapt effectively adversity, challenges, threats, may significant overcoming behavior. Objective aim this study was investigate psychological behavior...
Childhood cancer survivors (CCSs) are at increased risk of chronic health conditions, which could be controlled with behaviors. However, the behaviors and related factors Chinese CCSs remain unclear.The aims this study were to examine multiple among explore individual, interpersonal, home environmental affecting behaviors.This cross-sectional recruited 204 participants from 3 grade-A tertiary hospitals in Guangzhou, China. Participants provided data on (smoking, drinking, drug use, screen...