A5062280648- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Inflammasome and immune disorders
- Healthcare and Venom Research
- Marine Invertebrate Physiology and Ecology
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Lipid Membrane Structure and Behavior
- Antimicrobial Peptides and Activities
- Pesticide and Herbicide Environmental Studies
- Extracellular vesicles in disease
- Toxin Mechanisms and Immunotoxins
- Heme Oxygenase-1 and Carbon Monoxide
- Entomological Studies and Ecology
- Calpain Protease Function and Regulation
- Mosquito-borne diseases and control
- Amphibian and Reptile Biology
- Research on Leishmaniasis Studies
- Legionella and Acanthamoeba research
- Laser Applications in Dentistry and Medicine
- Pesticide Exposure and Toxicity
- Trypanosoma species research and implications
Fundação Oswaldo Cruz
2020-2024
Universidade Federal de Rondônia
2022-2023
Abstract Convulxin (CVX), a C-type lectin-like protein isolated from the venom of snake species, Crotalus durissus terrificus , stimulates platelet aggregation by acting as collagen receptor agonist for glycoprotein VI found in platelets. The effect CVX on platelets has been studied, but its human peripheral blood mononuclear cells (PBMCs) remains unclear. Given significance PBMCs inflammation, this study explored PBMCs, specifically regarding NLRP3 inflammasome activation assessing cell...
Snakebites represent a serious global public health problem, especially in tropical countries. In Brazil, the incidence of snakebites ranges from 19 to 22 thousand cases per 100000 persons annually. The state Rondônia, particular, has had an increasing snakebites.
Bothrops envenomation is associated with a cellular inflammatory response, characterized by pronounced neutrophil infiltration at the site of injury. Neutrophils act as first line defence, owing to their ability migrate infected tissue, promoting an acute response. At inflammation, neutrophils perform defence functions such phagocytosis, release proteolytic enzymes, generation reactive oxygen species (ROS), and synthesis mediators cytokines lipid mediators. can also form extracellular nets...
The parasite Leishmania (Viannia) braziliensis is widely distributed in Brazil and one of the main species associated with human cases different forms tegumentary leishmaniasis (TL) such as cutaneous (CL) mucosal (ML). mechanisms underlying pathogenesis TL are still not fully understood, but it known that factors related to host act a synergistic relevant way direct response infection. In host, macrophages have central connection play fundamental role defense organism due their ability...
Photobiomodulation therapy associated with conventional antivenom treatment has been shown to be effective in reducing the local effects caused by bothropic venoms preclinical studies. In this study, we analyzed influence of photobiomodulation using light emitting diode (LED) on oxidative stress produced murine macrophages stimulated Bothrops jararacussu venom and it isolated toxins BthTX-I BthTX-II. Under LED treatment, evaluated activity antioxidant enzymes catalase, superoxide dismutase,...
Crotalus Neutralizing Factor (CNF) is a γ-type Phospholipase A2 (PLA2) inhibitor present in the blood of durissus terrificus snake. Particularly, CNF inhibits toxic action Crotoxin (CTX), which major neurotoxin found C. d. venom. CTX induces also myotoxic and demonstrates high selectivity for skeletal muscle fibers. Consequently, can diffuse beyond site infection, potentially evoke rhabdomyolysis. The study has evaluated effects on myoblasts myotubes cells C2C12 vitro effect CTX-induced damage.
L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation platelet aggregation, hemorrhage, neutrophil activation. Human neutrophils respond LAAO by enhancing chemotaxis, phagocytosis, releasing reactive oxygen species (ROS) pro-inflammatory mediators. Exosomes cellular...
The focus of this study is to investigate the gene expression related formation neutrophil extracellular traps (NETs) stimulated by Calloselasma rhodostoma L-amino acid oxidase (Cr-LAAO). LAAOs found in snake venom have been shown activate human neutrophils, leading production reactive oxygen species (ROS), chemotaxis, phagocytosis, and release pro-inflammatory cytokines lipid mediators. Additionally, it has that Cr-LAAO activates NADPH oxidase, which responsible for ROS. Neutrophils are...