A5064208951- Venomous Animal Envenomation and Studies
- Inflammasome and immune disorders
- Rabies epidemiology and control
- Marine Invertebrate Physiology and Ecology
- Healthcare and Venom Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Erythrocyte Function and Pathophysiology
- Lipid Membrane Structure and Behavior
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Calpain Protease Function and Regulation
- Amphibian and Reptile Biology
- S100 Proteins and Annexins
- Ion channel regulation and function
- Trypanosoma species research and implications
- Viral Infections and Vectors
- Extracellular vesicles in disease
- Syphilis Diagnosis and Treatment
- Science and Education Research
- Research on Leishmaniasis Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Laser Applications in Dentistry and Medicine
- Entomological Studies and Ecology
- Pesticide Exposure and Toxicity
- Microfluidic and Bio-sensing Technologies
Fundação Oswaldo Cruz
2018-2024
Universidade Federal de Rondônia
2019-2023
John Wiley & Sons (United States)
2019
Abstract Convulxin (CVX), a C-type lectin-like protein isolated from the venom of snake species, Crotalus durissus terrificus , stimulates platelet aggregation by acting as collagen receptor agonist for glycoprotein VI found in platelets. The effect CVX on platelets has been studied, but its human peripheral blood mononuclear cells (PBMCs) remains unclear. Given significance PBMCs inflammation, this study explored PBMCs, specifically regarding NLRP3 inflammasome activation assessing cell...
Snake venom phospholipases A2 (PLA2s) have hemolytic, anticoagulant, myotoxic, oedematogenic, bactericidal, and inflammatory actions. BthTX-I, a Lys49-PLA2 isolated from Bothrops jararacussu venom, is an example of that presents such NLRP3 cytosolic receptor the NLR family responsible for inflammasome activation via caspase-1 IL-1β liberation. The study NLRs recognize tissue damage activate relevant in envenomation.Male mice (18-20 g) received intramuscular injection BthTX-I or sterile...
Abstract Cr-LAAO, an l -amino acid oxidase isolated from Calloselasma rhodosthoma snake venom, has been demonstrated as a potent stimulus for neutrophil activation and inflammatory mediator production. However, the mechanisms involved in Cr-LAAO induced not well characterized. Here we investigated Cr-LAAO-induced lipid body (also known droplet) biogenesis eicosanoid formation human neutrophils. Using microarray analysis, show first time that plays role up-regulation of expression genes...
Snakebites represent a serious global public health problem, especially in tropical countries. In Brazil, the incidence of snakebites ranges from 19 to 22 thousand cases per 100000 persons annually. The state Rondônia, particular, has had an increasing snakebites.
Bothrops envenomation is associated with a cellular inflammatory response, characterized by pronounced neutrophil infiltration at the site of injury. Neutrophils act as first line defence, owing to their ability migrate infected tissue, promoting an acute response. At inflammation, neutrophils perform defence functions such phagocytosis, release proteolytic enzymes, generation reactive oxygen species (ROS), and synthesis mediators cytokines lipid mediators. can also form extracellular nets...
The action of Cr-LAAO, an l-amino acid oxidase isolated from Calloselasma rhodosthoma snake venom, on NADPH activation in human neutrophil function was investigated. This enzyme has intrinsic activity hydrogen peroxide production. its native form, induces the ROS production and migration cytosolic components p40phox, p47phox p67phox to membrane, Rac, a GTPase protein member, with involvement intracellular signaling mediated by phospho PKC-α. In inactive iCr-LAAO does not induce showing that...
The parasite Leishmania (Viannia) braziliensis is widely distributed in Brazil and one of the main species associated with human cases different forms tegumentary leishmaniasis (TL) such as cutaneous (CL) mucosal (ML). mechanisms underlying pathogenesis TL are still not fully understood, but it known that factors related to host act a synergistic relevant way direct response infection. In host, macrophages have central connection play fundamental role defense organism due their ability...
Abstract BjcuL is a C-type lectin isolated from Bothrops jararacussu snake venom with specificity for binding β-d-galactose units. not toxic to human peripheral blood mononuclear cells (PBMCs), but it inhibits PBMC proliferation and stimulates these produce superoxide anions hydrogen peroxide primarily via lymphocyte stimulation; does stimulate the production of nitric oxide PGE2. The purpose this study was investigate effect on activation focus cytokine release modulating proliferation....
Photobiomodulation therapy associated with conventional antivenom treatment has been shown to be effective in reducing the local effects caused by bothropic venoms preclinical studies. In this study, we analyzed influence of photobiomodulation using light emitting diode (LED) on oxidative stress produced murine macrophages stimulated Bothrops jararacussu venom and it isolated toxins BthTX-I BthTX-II. Under LED treatment, evaluated activity antioxidant enzymes catalase, superoxide dismutase,...
Snakebite is a universally neglected public health problem. It victimizes approximately 2.5 million people annually and kills around 125 thousand. In Brazil, the Bothrops genus responsible for 87% of envenoming. The species erythromelas endemic in northeast region. Its venom induces local haemorrhage, coagulopathy, oedema, necrosis can lead to permanent disability or death. vitro effects (BeV) on thioglycollate-elicited macrophages were investigated this study. At non-cytotoxic...
Objetivo: relatar a experiência da qualificação dos trabalhadores rede de vigilância, atenção e prevenção transmissão vertical das infecções sexualmente transmitidas, principalmente sífilis congênita no estado Rondônia, partir projeto pesquisa nacional aplicado para o fortalecimento redes atenção. Método: metodologia problematização foi base construção do processo formativo, realizado através oficinas, com etapas teóricas, estudos casos clínicos plenárias. Resultados: notou-se participação...
Crotalus Neutralizing Factor (CNF) is a γ-type Phospholipase A2 (PLA2) inhibitor present in the blood of durissus terrificus snake. Particularly, CNF inhibits toxic action Crotoxin (CTX), which major neurotoxin found C. d. venom. CTX induces also myotoxic and demonstrates high selectivity for skeletal muscle fibers. Consequently, can diffuse beyond site infection, potentially evoke rhabdomyolysis. The study has evaluated effects on myoblasts myotubes cells C2C12 vitro effect CTX-induced damage.