A5000168500- Bipolar Disorder and Treatment
- Systemic Lupus Erythematosus Research
- Schizophrenia research and treatment
- Treatment of Major Depression
- Tryptophan and brain disorders
- Eating Disorders and Behaviors
- Monoclonal and Polyclonal Antibodies Research
- Peripheral Neuropathies and Disorders
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Child and Adolescent Psychosocial and Emotional Development
- Nicotinic Acetylcholine Receptors Study
- Mitochondrial Function and Pathology
- Cerebrovascular and genetic disorders
- Paraoxonase enzyme and polymorphisms
- Adolescent and Pediatric Healthcare
- Geology and Paleoclimatology Research
- RNA regulation and disease
- Venomous Animal Envenomation and Studies
- Glycogen Storage Diseases and Myoclonus
- Medical and Biological Sciences
- Extracellular vesicles in disease
- Plant Gene Expression Analysis
- Plant Stress Responses and Tolerance
- Nuclear Receptors and Signaling
Fundação Oswaldo Cruz
2023
BioCruces Health research Institute
2014-2020
Hospital de Cruces
2007-2020
Hospital Universitario Araba
2016-2017
National University of Northwestern Buenos Aires
2017
University of the Basque Country
2007-2014
Osakidetza
2010-2011
Hospital Santiago Apostol
2010-2011
Centro de Investigación Biomédica en Red de Salud Mental
2010-2011
Objective. The aim of this study was to analyse the relationship between glucocorticoids and damage accrual in SLE.
The aim of this 1-year follow-up study was to compare functional outcome as well clinical differences between patients with first- and multiple-episode bipolar disorder.Bipolar disorder first (n = 60) multiple episodes 59) were recruited from two hospitals in Spain. Functioning Assessment Short Test (FAST) used assess functioning. Hamilton Depression Rating Scale (HAMD) the Young Mania (YMRS) administered mood symptoms.As expected, episode experienced a greater functioning compared (11.26 ±...
<b>Background:</b> Recent studies suggest that antimalarials have antineoplastic properties. <b>Objective:</b> To investigate whether decrease the risk of cancer in systemic lupus erythematosus (SLE). <b>Methods:</b> An observational prospective cohort study was carried out. 235 patients were included at time diagnosis (American College Rheumatology criteria). The end point cancer. Kaplan–Meier cancer-free survival curves for treated and not with compared. A Cox proportional hazards model...
Objective To evaluate the subsequent rate of thrombosis among women with obstetric antiphospholipid syndrome (Ob‐ APS ) in a multicentre database antibody ( aPL )‐positive patients, and clinical utility adjusted Global Antiphospholipid Syndrome Score aGAPSS ), validated tool to assess likelihood developing new thrombosis, this group patients. Design Retrospective study. Setting The Alliance for Clinical Trials International Networking Database Repository. Population Women Ob‐ . Methods...
Aim The aim of this study was to evaluate the clinical response combined therapy with hydroxychloroquine and mepacrine in patients systemic lupus erythematosus refractory joint and/or skin disease. Methods Mepacrine added 46 unresponsive treatment following drug combinations: + prednisone immunosuppressive drugs ( n = 24), 16), retinoids 2), alone 1), one belimumab 1) or 1). outcome variable response, either complete partial, based on judgement. Cutaneous Lupus Erythematosus Disease Area...
The objective of this report is to analyse retinal changes over a five-year period, assessed by spectral domain-optical coherence tomography (SD-OCT), in patients from the Lupus-Cruces cohort treated with hydroxychloroquine (HCQ).SD-OCT screening was performed annually between 2012 and 2017. Average macular thickness (AMT), ganglion cell layer (GCLT) qualitative data pigment epithelium (RPE) external retina (ExtR) were collected prospectively. We compared (first) 2017 (second) SD-OCT.We...
Both acute pancreatitis and diffuse alveolar haemorrhage are rare conditions associated with systemic lupus erythematosus (SLE). In this case report, a 23-year-old female SLE was diagnosed lupus-associated and, within few days despite initial therapy pulse methyl-prednisolone, subsequently suffered an respiratory failure due to haemorrhage. The patient admitted the intensive care unit treatment intensified cyclophosphamide rituximab, which shortly induced complete remission of resolution...
Throughout the 20th century, a remarkable improvement in prognosis of systemic lupus erythematosus (SLE) has been seen, mostly due to better understanding disease and advent new therapies. However, plateau seems have reached. Whilst outcomes related active greatly improved, damage accrual tends be slowly increasing especially secondary high-dose glucocorticoids, which could lead not only increased morbidity but also worse long-term prognosis. Cardiovascular infections still account for...
L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation platelet aggregation, hemorrhage, neutrophil activation. Human neutrophils respond LAAO by enhancing chemotaxis, phagocytosis, releasing reactive oxygen species (ROS) pro-inflammatory mediators. Exosomes cellular...
There have been major advances in the treatment of epilepsy over past ten years, leading to marked changes way this illness is treated. However, introduction new drugs and non-drug treatments led uncertainty medical profession with regard their exact indications. For reason, a group neurologists Catalan Society Neurology drawn up guide-lines for epilepsy.A panel eight special interest diagnosis reviewed literature assess data available regarding epilepsy. A joint document was describing...
Background Mindfulness-based cognitive therapy (MBCT) is a psychotherapeutic intervention that has been shown effective in several clinical conditions. Nevertheless, research still needed on its effectiveness cognition. Objective To analyze possible effects cognition of the addition MBCT versus brief structured group psycho-education to standard treatment subsyndromal bipolar depression. Our hypothesis was could improve some aspects function higher degree than and as usual (TAU)....
Introduction Postpartum depression has a prevalence of 15% and consequences for mother baby (delayed physical, social cognitive development). It's essential to prevent the illness with an early identification Risk Factors (RF). Methods Five hundred seventy-two women in 3rd trimester pregnancy were evaluated selected those ≥ 1 RF ( n = 290). We re-evaluated postpartum Edinburgh Depression Scale subsyndromal depressive symptoms (≥ 7.5) 57). Clinical, demographic functional data collected....
Introduction Early onset forms of bipolar disorder may be difficult to distinguish from schizophrenia. Although operational criteria have become more precise, and there are diagnostic systems catalogue a psychotic adolescent, the clinicians continue having difficulties. Objective To know stability diagnosis definitively patients with symptoms during episodes, factors that can influence other diagnoses in first episode illness. Method 140 Araba, (Basque country) were included 2 years....