A5053966745- Advanced Cellulose Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Anodic Oxide Films and Nanostructures
- Nanocomposite Films for Food Packaging
- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- biodegradable polymer synthesis and properties
- Membrane-based Ion Separation Techniques
- Hydrogels: synthesis, properties, applications
- Electrochemical sensors and biosensors
- Nanoparticles: synthesis and applications
- Hemostasis and retained surgical items
- Chemical Safety and Risk Management
- Silk-based biomaterials and applications
- Pickering emulsions and particle stabilization
- Dialysis and Renal Disease Management
- Nanomaterials for catalytic reactions
- Enzyme Catalysis and Immobilization
- Safety Systems Engineering in Autonomy
- Polysaccharides and Plant Cell Walls
- Conducting polymers and applications
- Corneal Surgery and Treatments
- Chemistry and Chemical Engineering
- Antimicrobial Peptides and Activities
Uppsala University
2015-2024
Universidade Regional de Blumenau
2018
Institute of Molecular Functional Materials
2016
Angstrom Designs (United States)
2016
Universidad de la República
2006-2008
Universidad La República
2006
Centro Uruguayo de Imagenología Molecular
2003
The influence of nanostructure on the cytocompatibility cellulose films is analyzed providing insight into how physicochemical properties surface modified microfibrillated (MFC) and Cladophora nanocellulose (CC) affect materials cytocompatibility. CC through TEMPO-mediated oxidation glycidyltrimethylammonium chloride (EPTMAC) condensation to obtain anionic cationic samples respectively, while MFC are obtained by carboxymethylation EPTMAC respectively. Films unmodified, prepared vacuum...
Nanocellulose, and particularly nanofibrillated cellulose (NFC), has been proposed for a diversity of applications in industry the biomedical field. Its unique physicochemical structural features distinguish nanocellulose from traditional materials enable its use as an advance nanomaterial. However, nanoscale may induce unknown biological responses. Limited studies with NFC are available impacts have not thoroughly explored. This study assesses vitro responses elicited by wood-derived gels,...
Abstract Novel composites of nanocellulose and the conducting polymer polypyrrole (PPy) are herein suggested as potential candidates for active ion‐extraction membranes in electrochemically controlled hemodialysis. This study has defined processing parameters to obtain a biocompatible nanocellulose‐PPy composite, first time, effect composite aging on cell viability been studied. The influence rinsing extraction process steps, well under different conditions (i.e. air, at –20°C argon),...
A nanocellulose-reinforced poly(vinyl alcohol) hydrogel material of exceptionally high water content for ophthalmic applications is presented (>90 wt %), which also features a hitherto unprecedented combination optical, mechanical, viscoelastic, oxygen permeability, and biocompatibility properties. The combines the desired softness with remarkable strain-dependent mechanical strength thereby demonstrates hyperelastic, rubber-like observed unusual behavior due to both relatively stiff...
The GUIDEnano quality tool establishes objective criteria to score the of eco/toxicity studies performed with nanomaterials.
Composites of nanocellulose and the conductive polymer polypyrrole (PPy) are presented as candidates for a new generation haemodialysis membranes. The composites may combine active ion exchange with passive ultrafiltration, large surface area (about 80 m 2 g −1 ) could potentially provide compact dialysers. Herein, haemocompatibility novel membranes feasibility effectively removing small uraemic toxins by potential-controlled were studied. thrombogenic properties improved applying stable...
The effect of surface functionalization nanofibrillated cellulose (NFC) on monocyte/macrophage (MM) behavior is investigated to understand how the physicochemical properties nanocelluloses influence interactions such materials with biological systems. Films anionic (a-), cationic (c-), and unmodified (u-) NFC were synthesized characterized in terms charge. THP-1 monocytes cultured films for 24 h presence absence lipopolysaccharide, cell response was evaluated adhesion, morphology, secretion...
This work presents an insight into the relationship between cell response and physicochemical properties of Cladophora cellulose (CC) by investigating effect CC functional group density on model lines. was carboxylated electrochemical TEMPO-mediated oxidation. By varying amount charge passed through electrolysis setup, materials with different degrees oxidation were obtained. The carboxyl material's investigated together human dermal fibroblasts (hDF) osteoblastic cells (Saos-2) to films....
The present work investigates Ca2+ -crosslinked nanofibrillated cellulose hydrogels as potential hemostatic wound dressings by studying core interactions between the materials and a central component of wounds healing-the blood. Hydrogels wood-derived anionic (NFC) NFC that incorporate kaolin or collagen are studied in an vitro whole blood model with platelet-free plasma assays. evaluation thrombin factor XIIa formation, platelet reduction, release activated complement system proteins, shows...
Amorphous calcium phosphate (ACP) has shown significant effects on the biomineralization and promising applications in bio-medicine. However, limited stability porosity of ACP material restrict its practical applications. A storage stable highly porous with Brunauer–Emmett–Teller surface area over 400 m2/g was synthesized by introducing phosphoric acid to a methanol suspension containing amorphous carbonate nanoparticles. Electron microscopy revealed that constructed aggregated nanoparticles...
Wood-derived nanofibrillated cellulose (NFC) has long been recognized as a valuable nanomaterial for food-related applications. However, the safety of NFC cannot be predicted just from chemical nature cellulose, and there is need to establish effect nanofibers on gastrointestinal tract, reassure safe use in products. The present work selected intestinal cells Caco-2 gut bacteria Escherichia coli Lactobacillusreuteri evaluate vitro biological response NFC. materials with different surface...
Abstract The increasing antibiotic resistance among uropathogenic bacteria warrants alternative therapeutic strategies. We demonstrate the potential of synthetic peptide CD4-PP, designed by dimerization and backbone cyclization shortest antimicrobial region human cathelicidin, LL-37. CD4-PP is active against clinical type strains common uropathogens Escherichia coli , Klebsiella pneumoniae Pseudomonas aeruginosa at concentrations substantially below cellular cytotoxic levels induced membrane...
Transparent composite hydrogel in the form of a contact lens made from poly(vinyl alcohol) (PVA) and cellulose nanocrystals (CNCs) was subjected to vitro biocompatibility evaluation with human corneal epithelial cells (HCE-2 cells). The cell response direct hydrogels investigated by placing samples on top confluent layers evaluating viability, morphology, layer integrity subsequent 24 h culture removal hydrogels. To further characterize lens-cell interactions, HCE-2 were seeded hydrogels,...
Current trends in wound care research move toward the development of healing dressings designed to treat different types wounds (e.g., burns and chronic wounds) tailoring treatments for stages process. In this context, advanced nanotherapeutic materials is highlighted as a promising strategy efficiently control specific phases Here, Ca2+-cross-linked wood-derived nanofibrillated cellulose (NFC) hydrogels are evaluated dressings. vitro biocompatibility assays were performed study interaction...
Herein 2,3-dialdehyde cellulose beads prepared from Cladophora green algae nanocellulose were sulfonated and characterized by FTIR, conductometric titration, elemental analysis, SEM, ζ-potential, nitrogen adsorption–desorption laser diffraction, aiming for its application as a potential immunosorbent material. Porous at mild reaction conditions in water chemically modified sulfonation reduction. The obtained 15 µm sized found to be highly charged have high surface area of ~ 100 m2 g−1 pore...
Wood-derived nanofibrillated cellulose (NFC) has emerged as a sustainable material with wide range of applications and increasing presence in the market. Surface charges are introduced during preparation NFC to facilitate defibrillation process, which may also alter toxicological properties NFC. In present study, we examined vitro toxicity NFCs five surface chemistries: nonfunctionalized, carboxymethylated, phosphorylated, sulfoethylated, hydroxypropyltrimethylammonium-substituted. The...
Nanocellulose–oligoproline hydrogels, able to respond high levels of ROS and protect cells from oxidative environments, are promising candidates for the treatment chronic wounds other clinical conditions associated with ROS.
Two modern, fundamentally different methods were used for a detailed investigation of enantioselective drug−protein interactions, surface plasmon resonance (SPR)-based Biacore 2000 biosensor assay and the previously validated HPLC perturbation method (HPLC-PM). This is first time SPR has been this purpose. The fundamental features two investigated, consequences operation data evaluation addressed. With HPLC-PM, chiral could be obtained directly from racemic mixture, whereas separate analysis...
Within the EU FP-7 GUIDEnano project, a methodology was developed to systematically quantify similarity between nanomaterial (NM) that has been tested in toxicity studies and NM for which risk needs be evaluated, purpose of extrapolating data two materials. The is first attempt use current knowledge on property–hazard relationships develop series pragmatic systematic rules assessing similarity. Moreover, takes into account practical feasibility, it based generally available characterization...