A5073062734- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Family and Patient Care in Intensive Care Units
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Immune cells in cancer
- Ocular Oncology and Treatments
- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Heart Rate Variability and Autonomic Control
- Cardiac Arrest and Resuscitation
- Brain Metastases and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Telemedicine and Telehealth Implementation
- Neurosurgical Procedures and Complications
- Diabetic Foot Ulcer Assessment and Management
- Multiple Sclerosis Research Studies
Ljubljana University Medical Centre
2015-2024
Mayo Clinic in Florida
2024
University of Ljubljana
2024
Mayo Clinic in Arizona
2022-2023
Mayo Clinic
2021-2022
School of Business and Management Novo Mesto
2015
Montreal Neurological Institute and Hospital
2014-2015
McGill University
2014-2015
University Clinical Centre Maribor
2009-2011
In multiple sclerosis, successful remyelination within the injured CNS is largely dependent on survival and differentiation of oligodendrocyte progenitor cells. During inflammatory injury, oligodendrocytes cells lesion sites are exposed to secreted products derived from both infiltrating immune cell subsets CNS-resident Such may be considered either proinflammatory or anti-inflammatory have potential contribute injury repair processes. Within CNS, astrocytes also significantly biology during...
Dimethyl fumarate (DMF), a therapy for relapsing-remitting multiple sclerosis (RRMS), is implicated as acting on inflammatory and antioxidant responses within both systemic immune and/or central nervous system (CNS) compartments. Orally administered DMF rapidly metabolized to monomethyl (MMF). Our aim was analyze the impact of fumarates antiinflammatory profiles human myeloid cells found in compartment (monocytes) inflamed CNS (blood-derived macrophages brain-derived microglia).We analyzed...
The aim of our study was to evaluate the effects Trendelenburg position, infusion 6% hydroxyetyl starch solution or lactated Ringer's on changes in cardiac output (CO) after spinal anesthesia patients older than 50 yr.Seventy scheduled for lower extremity orthopedic surgery under were allocated randomly one three treatment groups. In group, placed position immediately block 10 min. hydroxyethyl group and received an 500 mL 1000 over 20 min block. CO measured continuously from 15 before until...
This study compared the influence of Trendelenburg position on haemodynamics in non-anaesthetized spontaneously breathing healthy volunteers and anaesthetized, mechanically ventilated patients with ischaemic heart disease scheduled for coronary artery bypass graft (CABG) surgery. Placing anaesthetized CABG surgery resulted a significant increase cardiac output mean arterial pressure non-significant decrease rate. In contrast, volunteers, rate increased significantly but both changed...
IMPORTANCE: Initial Society of Critical Care Medicine Discovery Viral Infection and Respiratory illness Universal Study (VIRUS) Registry analysis suggested that improvements in critical care processes offered the greatest modifiable opportunity to improve critically ill COVID-19 patient outcomes. OBJECTIVES: The Structured Team-based Optimal Patient-Centered for Virus ICU Collaborative was created identify speed implementation best evidence based practices. DESIGN, SETTING, AND PARTICIPANTS:...
Multisystem inflammatory syndrome is a life-threatening condition associated with elevated markers and multiple organ injury. A diagnosis of exclusion, it has been reported after severe acute respiratory coronavirus 2 infection (SARS-CoV-2) in children adults; recently described some post-COVID-19 vaccinated individuals. The prognosis supportive care immunomodulatory therapy good, although individuals may require treatment the intensive unit (ICU). Here we report case 58-year-old man who...
OBJECTIVE: To compare the in vivo and vitro effects of DMF MMF on human monocytes. BACKGROUND: therapy reduces relapse rates multiple sclerosis (MS). In experimental models, inhibits production pro-inflammatory molecules, induces anti-oxidant responses. vivo, is rapidly metabolized to MMF, thought be biologically active agent. Expression cytokine regulator microRNA-155 (miR-155) up-regulated monocytes untreated MS patients compared healthy controls. DESIGN/METHODS: Monocytes obtained from...
Brown, Meghan1; Garbajs, Nika Zorko2; Garces, Juan Pablo Domecq3; Tekin, Aysun1; Bansal, Vikas4; Das, Subhraleena5; Muigai, Maureen5; Boisseau, Robert5; Khan, Syed Anjum6; Gajic, Ognjen7; Jain, Nitesh6 Author Information
Background This study aims to assess the association of postoperative stroke with intraoperative hemodynamic variability and transfusion management. Methods In this case-control study, adult patients (≥ 18 years) who had a within 72 hours surgical procedure were matched 2 control according age, sex, type. Primary risk factors assessed fluid administration, blood product transfusion, vasopressor use, measures in systolic diastolic pressure heart rate: maximum, minimum, range, SD, average real...
Zec, Simon; Dong, Yue; Garbajs, Nika Zorko; Sun, Yuqiang; Bogojevic, Marija; Gajic, Ognjen; Singh, Romil; Hielsberg, Christina; Niven, Alexander Author Information