A5070109915- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Frailty in Older Adults
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Anesthesia and Pain Management
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Orthopaedic implants and arthroplasty
- Nausea and vomiting management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Total Knee Arthroplasty Outcomes
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Opioid Use Disorder Treatment
- Parasite Biology and Host Interactions
- Nuclear Receptors and Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Music Therapy and Health
- Parkinson's Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Mollusks and Parasites Studies
- Electrical and Bioimpedance Tomography
Mayo Clinic in Arizona
2020-2024
Mayo Clinic in Florida
2023
Mayo Clinic
2020-2022
Molins (United Kingdom)
2018
BACKGROUND: The frequency and temporal distribution of postoperative respiratory depression (RD) events are not completely understood. This study determined the RD episodes in postsurgical patients continuously monitored by bedside capnography pulse oximetry. METHODS: was a post hoc subset enrolled PRediction Opioid-induced Depression In capnoGraphY (PRODIGY) trial from 2 sites United States. These had undergone continuous monitoring on general care wards. data were adjudicated for potential...
IMPORTANCE Hospitalizations are associated with cognitive decline in older adults. OBJECTIVE To determine the association between hospitalization characteristics and trajectory of function DESIGN Population‐based longitudinal study aging. SETTING Olmsted Medical Center Mayo Clinic, only centers County, Minnesota, capacity. PARTICIPANTS Individuals without dementia at baseline, consecutive assessments from 2004 through 2017, least one visit after age 60. MEASUREMENTS The primary outcome was...
The anesthesia recovery is a complex physiologic process as systems recover from the effects of surgery and anesthesia. Inadequate respiratory physiology can lead to severe hypoxemia-induced end-organ damage even death. Emerging evidence suggests that signs depression during early may portend increased risk for future adverse events. This article briefly reviews Mayo Clinic research experience advances in clinical practice. From implementation step-down model discharge criteria...
There is concern regarding potential long-term cardiotoxicity with systemic distribution of metals in total joint arthroplasty (TJA) patients.
Importance Individuals with total joint arthroplasty (TJA) have long-term exposure to metal-containing implants; however, whether artificial implants is associated cognitive function unknown. Objective To compare trajectories in individuals and without TJA. Design, Setting, Participants This population-based cohort study assessed serial evaluations of 5550 participants (≥50 years age) from the Mayo Clinic Study Aging between November 1, 2004, December 31, 2020. Exposures Total hip or knee....
Abstract Background We describe the clinical course of medical and surgical patients who received naloxone on general hospital wards for suspected opioid-induced respiratory depression (OIRD). Methods From May 2018 through October 2020, were identified their records reviewed incidence course. Results There 86,030 106,807 admissions. Naloxone was administered to 99 (incidence 11.5 [95% confidence interval 9.4–14.0] per 10,000 admissions) 63 (5.9 4.5–7.5]) (P < 0.001). Median oral...
Objectives Delayed anesthesia recovery following endoscopic sinus surgery (ESS) can be an indicator of immediate complications and negatively impact healthcare efficiency. This study aims to examine clinical factors with a focus on improving practice. Methods Medical records patients undergoing ESS under general from 2014 2018 were reviewed. Based the interquartile range for cohort, in upper quartile categorized as “prolonged” lowest three quartiles “goal” recovery. Patient surgical...
Background Postoperative in-hospital pneumonia is a serious complication. This study aims to investigate the association between 3 preoperative stratification tools (American Society of Anesthesiologists Physical Status [ASA-PS] score, Charlson Comorbidity Index [CCI], and Rockwood Frailty Deficit [FI]) risk for postoperative pneumonia. Methods We identified adult patients who developed following noncardiothoracic surgery under general anesthesia, January 1, 2016 December 31, 2017. Patients...
To investigate if sex-specific physiologic characteristics could impact postoperative respiratory depression risks in women, we studied incidence and risk factors associated with a gynecologic surgical cohort. Only hysterectomies performed under general anesthesia from 2012 to 2017 were included minimize interprocedural variability. Respiratory was defined as episodes of apnea, hypopnea, hypoxemia, pain-sedation mismatch, unplanned positive airway pressure device application, or naloxone...
Supplemental oxygen (SO) potentiates opioid-induced respiratory depression (OIRD) in experiments on healthy volunteers. Our objective was to examine the relationship between SO and OIRD patients surgical units.This post-hoc analysis utilized a portion of observational PRediction Opioid-induced Depression In monitored by capnoGraphY (PRODIGY) trial dataset (202 patients, two sites), which involved blinded continuous pulse oximetry capnography monitoring postsurgical units. incidence...
Manipulation of carcinoid tumors during ablation or selective hepatic artery embolization (transarterial embolization, TAE) can release vasoactive mediators inducing hemodynamic instability. The main aim our study was to review hemodynamics and complications related minimally invasive treatments liver carcinoids with TAE ablation. Electronic medical records all patients metastatic undergoing from 2003 2019 were abstracted. Noted severe hypotension (mean arterial pressure [MAP] ≤ 55 mmHg),...
Symptomatic cats infected by Aelurostrongylus abstrusus show non-specific and respiratory clinical signs, often misdiagnosed as other diseases more prevalent among feline population, such allergic disease or heartworm associated (HARD). Clinical signs are due to the pulmonary inflammatory response caused eggs shed adult females migration of first-stage larvae up bronchial tree. Barometric whole-body plethysmography (BWBP) is a non-invasive function test that allows dynamic study breathing...
Abstract Background Hospitalization can impair physical and functional status of older adults, but it is unclear whether these deficits are transient or chronic. This study determined the association between hospitalization adults changes in long-term longitudinal trajectories 2 measures status: gait speed (GS) instrumental activities daily living measured with Functional Activities Questionnaire (FAQ). Method Linear mixed-effects models assessed (nonelective vs elective, surgical medical)...
Background Postoperative falls are preventable complications. The study aims were to describe the rate and circumstances surrounding postoperative explore potential associations with patient procedural characteristics emphasis on use of sedative medications. Methods Medical records hospitalized patients undergoing non-lower extremity surgery under general anesthesia from January 1, 2010, through April 30, 2018 reviewed for within 72 hours. Perioperative sedatives, sleep aids, gabapentinoids,...
Hospitalization in older age is associated with accelerated cognitive decline, typically preceded by neuropathologic changes. We assess the association between indication for hospitalization and brain neurodegeneration. Included were participants from Mayo Clinic Study of Aging, a population-based longitudinal study, ≥1 imaging available those than 60 years 2004 2017. Primary analyses used linear mixed-effects models to changes trajectory cortical thinning, amyloid accumulation, white matter...
Background This study aims to assess the association of postoperative stroke with intraoperative hemodynamic variability and transfusion management. Methods In this case-control study, adult patients (≥ 18 years) who had a within 72 hours surgical procedure were matched 2 control according age, sex, type. Primary risk factors assessed fluid administration, blood product transfusion, vasopressor use, measures in systolic diastolic pressure heart rate: maximum, minimum, range, SD, average real...