A5100351039- Skin Protection and Aging
- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Cancer and Skin Lesions
- Photochemistry and Electron Transfer Studies
- Spectroscopy and Quantum Chemical Studies
- Spectroscopy and Laser Applications
- Photochromic and Fluorescence Chemistry
- Atmospheric chemistry and aerosols
- Light effects on plants
- DNA and Nucleic Acid Chemistry
- Laser Applications in Dentistry and Medicine
- Catalytic C–H Functionalization Methods
- Allergic Rhinitis and Sensitization
- Wound Healing and Treatments
- Food Allergy and Anaphylaxis Research
- Vascular Tumors and Angiosarcomas
- Microbial Natural Products and Biosynthesis
- Nonmelanoma Skin Cancer Studies
- Analytical chemistry methods development
- Cerebral Venous Sinus Thrombosis
- Neonatal skin health care
- IL-33, ST2, and ILC Pathways
- Hedgehog Signaling Pathway Studies
University of Chinese Academy of Sciences
2015-2024
Vanderbilt University
2024
VA Tennessee Valley Healthcare System
2022-2024
Dalian Institute of Chemical Physics
2014-2024
Chinese Academy of Sciences
2007-2024
Union Hospital
2020-2024
Huazhong University of Science and Technology
2020-2024
Tianjin University of Technology
2022-2023
Vanderbilt University Medical Center
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Enterovirus 71 (EV71) has emerged as a major cause of neurological disease following the near eradication poliovirus. Accumulating evidence suggests that mammalian microRNAs (miRNAs), class noncoding RNAs 18 to 23 nucleotides (nt) with important regulatory roles in many cellular processes, participate host antiviral defenses. However, miRNAs EV71 infection and pathogenesis are still unclear. Here, hsa-miR-296-5p expression was significantly increased EV71-infected human cells. As determined...
Abstract We describe a novel, minimally invasive laser technology for skin rejuvenation by creating isolated microscopic lesions within tissue below the epidermis using induced optical breakdown. Using an in‐house built prototype device, tightly focused near‐infrared pulses are used to create breakdown in dermis while leaving intact, resulting due cavitation and plasma explosion. This stimulates healing response consequently remodelling, effects. Analysis of ex‐vivo in‐vivo treated human...
Sunscreens are aimed at protecting skin from solar ultraviolet (UV) irradiation. By utilizing femtosecond transient absorption spectroscopy and time-dependent density functional theory, we explain nature's selection of sinapoyl malate rather than sinapic acid as the plant sunscreen molecule. In physiological pH conditions, two molecules deprotonated, their excited ππ* states found to relax ground in a few tens picoseconds via barrierless trans–cis photoisomerization. After cis-photoproduct...
Keloid is one of the most frustrating problems related to wounding healing and presents a great challenge in clinic. MicroRNAs (miRs) have shown their potential as novel therapy for prevention treatment keloid. Vascular endothelial growth factor (VEGF) plays critical role regulation scar development. In current study, it was hypothesized that miR-205-5p capable suppressing keloid formation by inhibiting VEGF-mediated wound cascade. The expression statuses VEGF clinical tissues cell line...
There is sufficient evidence indicating that keloid strongly associated with atopic dermatitis (AD) across ethnic groups. However, the molecular mechanism underlying association not fully understood. The aim of this study to discover between and AD by integrating comprehensive bioinformatics techniques machine learning methods. gene expression profiles were downloaded from Gene Expression Omnibus (GEO) database. A total 449 differentially expressed genes (DEGs) found be shared in using...
We demonstrate the efficacy of a novel minimally invasive nonthermal skin rejuvenation technique for wrinkle and fine-line reduction based on laser-induced optical breakdown. The breakdown caused by tightly focused near-infrared laser pulses creates grid intradermal lesions without affecting epidermis, leading to rejuvenation. pilot in vivo test performed five subjects successfully demonstrates reduction, improvement other features pain or any unpleasant sensations social downtime associated...
Goal: To improve the signal-to-noise ratio (SNR) of magnetic resonance spectroscopic imaging (MRSI) data. Methods: A low-rank filtering method recently proposed for denoising MRSI data is extended by: 1) incorporating tissue boundary constraints to enable local filtering, and 2) integrating B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> field inhomogeneity correction by rank-minimization make model more effective. Results: The was...
Abstract Chronic pruritus is a prominent symptom of allergic contact dermatitis (ACD) and represents huge unmet health problem. However, its underlying cellular molecular mechanisms remain largely unexplored. TRPC3 highly expressed in primary sensory neurons has been implicated peripheral sensitization induced by proinflammatory mediators. Yet, the role acute chronic itch still not well defined. Here, we show that, among mouse trigeminal ganglion (TG) neurons, Trpc3 mRNA predominantly...
An ultraviolet energy dissipation mechanism plays a critical role in the photoprotection effect of sunscreens. In this work, we discovered substitution dependent UV mechanisms model plant sunscreen methyl sinapate (MS). We found that initially populated V(ππ*) states MS and p-OMeMS relax to ground state nonradiatively along an ultrafast trans–cis photoisomerization tens picoseconds. However, for p-HMS, internal conversion from relative dark V′(ππ*) occurs less than 1 ps, leading branching...
Summary Background Cumulative lifetime sun exposure is accepted as having a very important role to play in the expression of signs photoaging, which then superimposed on intrinsic processes involved chronological aging skin. Many groups have evaluated effects emulsion‐based products, mostly although not exclusively, face using variety actives including retinoids and antioxidants. Nevertheless, effect topical anhydrous product photodamaged skin has been reported literature. Aims The objective...
Exposure to ultraviolet (UV) light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, which increases oxidative stress damage leads photoaging. Nuclear factor E2-related 2 (Nrf2) modulates antioxidant defense cells against environmental factors, especially radiation. Natural products that target Nrf2-regulated reactions are promising candidates for anti-photoaging. The aim this study was investigate protective effect Modified Qing'e Formula (MQEF)...
Transition-metal-catalyzed allylation of azlactones represents an elegant strategy for the synthesis valuable α-quaternary amino acids. While much progress has been achieved, catalytic prenylation and reverse have less explored. Regiodivergent catalysis, aiming at attaining distinct regioisomers from same starting materials through varying catalyst, is emerging in synthetic chemistry. Herein, we present atom-economical coupling isoprene with palladium catalysis which ligand-controlled...
In this study, a strategy was developed for in situ, non-intrusive, and quantitative measurement of the oxides nitrogen (NO NO2) to describe emission characteristics gas turbines. The linear calibration-free wavelength modulation spectroscopy (LCF-WMS) approach combined with temperature profile-fitting utilized trace NO NO2 concentration detection broad spectral interference from gaseous water (H2O). Transition lines near 1308 nm, 5238 6250 nm were selected investigate H2O, NO, generated...
Atopic Dermatitis (AD) or eczema, a recurrent allergic inflammation of the skin, afflicts 10-20% children and 5% adults all racial ethnic groups globally. We report new topical treatment AD by Nuclear Transport Checkpoint Inhibitor (NTCI), which targets two nuclear transport shuttles, importin α5 β1. In preclinical model AD, induced active vitamin D3 analog MC903 (calcipotriol), NTCI suppressed expression keratinocyte-derived cytokine, Thymic Stromal Lymphopoietin (TSLP), key gene in...
Extramammary Paget's disease (EMPD) is a rare cutaneous neoplasm with distant metastases and poor prognosis. We report the case of 63-year-old male patient exhibiting stage IV primary EMPD neuroendocrine differentiation, harboring somatic mutation in AMER1. After four cycles Anlotinib combined Tislelizumab, achieved partial response for metastatic lesions according to mRECIST1.1 criteria. Total positron emission tomography computed (PET-CT) scans revealed significant reduction SUV from 18.9...