A5076353880- Genetic Neurodegenerative Diseases
- Glycosylation and Glycoproteins Research
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Galectins and Cancer Biology
- Autophagy in Disease and Therapy
- Nerve injury and regeneration
- Ginseng Biological Effects and Applications
- Ubiquitin and proteasome pathways
- Carbohydrate Chemistry and Synthesis
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Mosquito-borne diseases and control
Universidade Federal de Santa Catarina
2018-2023
Lectins are a class of carbohydrate-binding proteins or glycoproteins with diverse specificities and functions. The determination characterization the three-dimensional structures these keys to understanding their biological effects. Recent studies have explored anticancer potential Diocleinae lectins (from Leguminoseae family), evaluating antiproliferative effect ability induce glioma cell death via apoptosis autophagy. In this work, structure Dioclea lasiophylla seed lectin (DlyL)...
The antitumor activity of DVL, a lectin purified from Dioclea violacea seeds, on the U87 human glioma cell line was evaluated and compared with Canavalia ensiformis (ConA). Treatment DVL (10–100 μg/mL; 24–96 h) induced alterations in morphology, decreased numbers clonogenic survival time- concentration-dependent manner. caused significant decreases viability impaired migration. Mechanistically, treatment (12 disrupted mitochondrial electrochemical gradient, without ROS accumulation or...
A glioblastoma (GBM) is a highly malignant primary brain tumor with poor prognosis because of its invasiveness and high resistance to current therapies. In GBMs, abnormal glycosylation patterns are associated malignancy, which allows for the use lectins as tools recognition therapy. More specifically, can interact glycan structures found on cell surface. this context, present work aimed investigate antiglioma potential ConGF, lectin purified from Canavalia grandiflora seeds, against C6...
Huntington's disease (HD) is a neurodegenerative genetic disorder characterized by motor, psychiatric, cognitive, and peripheral symptoms without effective therapy. Evidence suggests that lifestyle factors can modulate onset progression, environmental enrichment (EE) has emerged as potential approach to mitigate the progression severity of processes. Wild-type (WT) yeast artificial chromosome (YAC) 128 mice were exposed different EE conditions. Animals from cohort 1 between postnatal days 21...
Huntington's disease (HD) is a genetic neurodegenerative characterized by motor, psychiatric, and cognitive symptoms. Emerging evidence suggests that emotional deficits seen in HD may be related to hippocampal dysfunction. We used the YAC128 mouse model perform temporal characterization of behavioral dysfunctions. Early late symptomatic mice exhibited depressive-like behavior, as demonstrated increased immobility times Tail Suspension Test. In addition, Swimming T-maze Test during stage....