A5024171439- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Pluripotent Stem Cells Research
- Cardiomyopathy and Myosin Studies
- Connective tissue disorders research
- Cardiac Structural Anomalies and Repair
- Cardiac Fibrosis and Remodeling
- 3D Printing in Biomedical Research
- Aortic aneurysm repair treatments
- Energy and Environment Impacts
- Neonatal Respiratory Health Research
- Salmonella and Campylobacter epidemiology
- ECG Monitoring and Analysis
- Cardiovascular Issues in Pregnancy
- Viral Infections and Immunology Research
- Phonocardiography and Auscultation Techniques
- Antibiotic Use and Resistance
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Antibiotic Resistance in Bacteria
- Fibroblast Growth Factor Research
- Signaling Pathways in Disease
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Takotsubo Cardiomyopathy and Associated Phenomena
Yale Cancer Center
2019-2024
Yale University
2019-2024
Tameside Hospital
2016
Tameside and Glossop Integrated Care NHS Foundation Trust
2016
Pakistan Institute of Engineering and Applied Sciences
2009
Background: Familial hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and typically caused by mutations in genes encoding sarcomeric proteins that regulate contractility. HCM manifestations include left ventricular hypertrophy heart failure, arrythmias, sudden death. How dysregulated force production sensed leads to pathological remodeling remains poorly understood HCM, thereby inhibiting efficient development of new therapeutics. Methods: Our discovery was...
This paper presents a comparison of different approaches for performing baseline removal in the electrocardiogram (ECG) signal use an ECG based decision support system diagnosis coronary heart disease. Our implementations seven algorithms from have been compared which include methods on linear Digital filters, Adaptive Multiresolution analysis and Curve fitting or polynomial approaches. The was carried out using manual ST Segment level annotations segment deviation episodes European Society...
To better define the role of mechanical forces in pulmonary emphysema, we employed methods recently developed our laboratory to identify microscopic level relationships between airspace size and elastin-specific desmosine isodesmosine (DID) cross links normal emphysematous human lungs. Free DID wet tissue (a biomarker for elastin degradation) total formalin-fixed, paraffin-embedded (FFPE) sections were measured using liquid chromatography-tandem mass spectrometry correlated with alveolar...
BACKGROUND: A series of incurable cardiovascular disorders arise due to improper formation elastin during development. Supravalvular aortic stenosis (SVAS), resulting from a haploinsufficiency ELN , is caused by stress sensing medial vascular smooth muscle cells, leading progressive luminal occlusion and heart failure. SVAS remains incurable, as current therapies do not address the root issue defective elastin. METHODS: We use here model proliferative disease using both human induced...
Decompensated hypothyroidism is a rare endocrine emergency but differential that should be considered in patients presenting critically unwell with systemic illness. We report case of myxoedema coma woman respiratory failure, hypotension, hypothermia and reduced level consciousness, all which are poor prognostic features decompensated hypothyroidism. The patient was admitted to critical care for mechanical ventilation cardiovascular support treated combination insulin, liothyronine...
Abstract Familial cardiomyopathy is a precursor of heart failure and sudden cardiac death. Over the past several decades, researchers have discovered numerous gene mutations primarily in sarcomeric cytoskeletal proteins causing two different disease phenotypes: hypertrophic (HCM) dilated (DCM) cardiomyopathies. However, molecular mechanisms linking genotype to phenotype remain unclear. Here, we employ systems approach by integrating experimental findings from preclinical studies (e.g.,...