A5084212220- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Monoclonal and Polyclonal Antibodies Research
- Nanocluster Synthesis and Applications
- RNA Interference and Gene Delivery
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Advanced Biosensing Techniques and Applications
- Radioactive element chemistry and processing
- Genetics, Bioinformatics, and Biomedical Research
- Corrosion Behavior and Inhibition
- Biological Research and Disease Studies
- Curcumin's Biomedical Applications
- Catalysis and Oxidation Reactions
- Protein purification and stability
- Chemical Synthesis and Analysis
- Gas Sensing Nanomaterials and Sensors
- Alzheimer's disease research and treatments
- Click Chemistry and Applications
- Quantum Dots Synthesis And Properties
- Proteins in Food Systems
- Transition Metal Oxide Nanomaterials
- Neuropeptides and Animal Physiology
University of Milano-Bicocca
2014-2019
Mylan (Switzerland)
2019
Milano University Press
2019
Luigi Sacco Hospital
2014
University of Milan
2012-2013
Institute of Molecular Science and Technologies
2012
St Petersburg University
2010-2011
The discovery of new solutions with antibacterial activity as efficient and safe alternatives to common preservatives (such parabens) combat emerging infections drug-resistant bacterial pathogens is highly expected in cosmetics pharmaceutics. Colloidal silver nanoparticles (NPs) are attracting interest novel effective antimicrobial agents for the prevention several infectious diseases.Water-soluble, negatively charged (AgNPs) were synthesized by reduction citric tannic acid characterized...
Triple negative breast cancer (TNBC) is a highly aggressive, invasive, and metastatic tumor. Although it reported to be sensitive cytotoxic chemotherapeutics, frequent relapse chemoresistance often result in treatment failure. In this study, we developed biomimetic nanodrug consisting of self-assembling variant (HFn) human apoferritin loaded with curcumin. HFn nanocage improved the solubility, chemical stability, bioavailability curcumin, allowing us reliably carry out several experiments...
We report the development of an efficient antibody delivery system for incorporation trastuzumab (TZ) into poly(lactic-co-glycolic) acid nanoparticles (PLGA NPs). The aim work was to overcome current limitations in clinical use therapeutic antibodies, including immunogenicity, poor pharmacokinetics, low tumor penetration and safety issues.Trastuzumab-loaded PLGA NPs (PLGA-TZ) were synthesized according a double emulsion method. same protocol used produce control batches nonspecific...
All bound up: A small variant of protein (red; see picture) was used as a biotemplate for the synthesis and biofunctionalization gold nanoparticles (AuNPs). These functionalized AuNPs were able to bind antibodies (green blocks, trastuzumab; TZ) with defined orientation, thus showing promise bio-nanoparticle systems suitable selective cell labeling by membrane-receptor-specific recognition.
A novel approach for multivalent targeting by using gold nanoparticles noncovalently decorated tight functionalization with a cone-glycocalixarene bearing four mannose units is reported. The efficiency of these shown to be remarkably improved compared that monovalent mannosylated derivative.
The goal of this work is to develop an innovative approach for the coating gold nanoparticles (AuNPs) with a synthetic functional copolymer. This stable thickness few nanometers provides, at same time, stabilization and functionalization particles. polymeric consists backbone polydimethylacrylamide (DMA) functionalized alkyne monomer that allows binding azido modified molecules by Cu(I)-catalyzed azide/alkyne 1,3-dipolar cycloaddition (CuAAC, click chemistry). thin polymer layer on surface...
Gold nanoparticles were obtained by reduction of a tetrachloroaurate aqueous solution in the presence RGD-(GC)(2) peptide as stabilizer. As comparison, behavior (GC)(2) has been studied. The and peptides prepared ad hoc Fmoc synthesis. colloidal systems have characterized UV-visible, TGA, ATR-FTIR, mono bidimensional NMR techniques, confocal transmission (TEM) microscopy, ζ-potential, light scattering measurements. efficient cellular uptake Au-RGD-(GC)(2) Au-(GC)(2) stabilized gold into U87...
Gold nanocages (AuNCs) have been shown to be a useful tool for harnessing imaging and hyperthermia therapy of cancer, thanks their unique optical properties, low toxicity, facile surface functionalization. Herein, we use AuNCs selective targeting prostate cancer cells (PC3) via specific interaction between neuropeptide Y (NPY) receptor three different NPY analogs conjugated AuNCs. Localized plasmon resonance band the nanoconjugates was set around 800 nm, which is appropriate in vivo...
The functionalization of colloidal nanoparticles with short peptides often fails in achieving satisfactory targeting efficiency and selectivity toward receptor-specific human cells. Here, we show that an optimized passivation gold nanoparticle surface a mixed self-assembled monolayer, including ligand, fluorescent dye, intercalating PEG derivative, led to very stable, nontoxic, efficient nanoconjugate for urokinase plasminogen activator receptor-positive breast cancer
The efficient targeting of cancer cells depends on the success obtaining active overexpressed receptors. A very accurate design nanoconjugates should be done via selection conjugation strategy to achieve effective targeted nanoconjugates. Here, we present a detailed study cetuximab-conjugated nonspherical gold nanocages for triple-negative breast cells, including MDA-MB-231 and MDA-MB-468. few different general strategies were selected monoclonal antibody nanoparticle surface. By varying...
Gold nanoparticles capped by thymine, thymidine and 5′-monophosphate were prepared characterised spectroscopy microscopy techniques. AuNPs incubated with U87 cancer cells taken up showed a particular ability to overcome intracellular boundaries, being present in various cell compartments.
The interactions between DNA and AuNPs is one of the most interesting subjects modern nanotechnology, giving rise to plenty applications. studies on identification binding sites components gold nanoparticle are continuously in progress; however, information about how interaction influences conformation guanine compounds still lacking. In this paper, we report preparation modified by ligands via a one-pot reduction method aqueous solution. nanoparticles were fully characterized UV–vis, TEM,...
Alles hängt irgendwie zusammen: Eine kleine Variante von Protein A (rot im Bild) wurde als Templat für die Synthese und Biofunktionalisierung Goldnanopartikeln (AuNPs) genutzt. Die funktionalisierten AuNPs konnten in definierter Orientierung an Antikörper (grün, Trastuzumab; TZ) binden, was sie eine selektive Zellmarkierung aufgrund spezifischer Erkennungsprozesse mit Membranrezeptoren interessant macht. Detailed facts of importance to specialist readers are published as ”Supporting...
Eine rekombinante Protein-A-Variante (grün) wurde von F. Porta, D. Prosperi et al. in ihrer Zuschrift auf S. 9406 ff. als Templat bei der Synthese sphärischer Goldnanopartikel (rot) genutzt. Zugleich wurden monoklonale Antikörper (blau) Oberfläche Nanopartikel einer Orientierung immobilisiert, die für Erkennung durch spezifische Zellrezeptoren optimal ist. Bild: Enzo Fezzuoglio.
Gold nanocages (AuNCs) have been shown to be a useful tool both for imaging and hyperthermia therapy of cancer, thanks their outstanding optical properties, low toxicity facile functionalization with targeting molecules, including peptides antibodies. In particular, is minimally invasive which takes advantage the peculiar properties gold nanoparticles efficiently convert absorbed light into heat. Here, we use AuNCs selective prostate cancer cells. Moreover, report hyperthermic effect...