A5070549070- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Drug Solubulity and Delivery Systems
- Peptidase Inhibition and Analysis
- Parasitic Diseases Research and Treatment
- Animal Nutrition and Physiology
- Helminth infection and control
- Graphene and Nanomaterials Applications
- HER2/EGFR in Cancer Research
- Proteins in Food Systems
- Parasite Biology and Host Interactions
- Quantum Dots Synthesis And Properties
- Nanoparticles: synthesis and applications
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Alzheimer's disease research and treatments
- Chemical Synthesis and Analysis
- Protein Interaction Studies and Fluorescence Analysis
- Osteoarthritis Treatment and Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Protein purification and stability
- Microencapsulation and Drying Processes
- Advanced biosensing and bioanalysis techniques
University of Milano-Bicocca
2017-2019
University of Pavia
2012-2018
We report the development of an efficient antibody delivery system for incorporation trastuzumab (TZ) into poly(lactic-co-glycolic) acid nanoparticles (PLGA NPs). The aim work was to overcome current limitations in clinical use therapeutic antibodies, including immunogenicity, poor pharmacokinetics, low tumor penetration and safety issues.Trastuzumab-loaded PLGA NPs (PLGA-TZ) were synthesized according a double emulsion method. same protocol used produce control batches nonspecific...
Abstract: The human epidermal growth factor receptor 2 (HER2) is normally associated with a highly aggressive and infiltrating phenotype in breast cancer lesions propensity to spread into metastases. In clinic, the detection of HER2 primary tumors their metastases currently based on invasive methods. Recently, nuclear molecular imaging techniques, including positron emission tomography single photon computed (SPECT), allowed vivo. We have developed 99m Tc-radiolabeled nanosilica system,...
One of the goals pharmaceutical sciences is amelioration targeted drug delivery. In this context, nanocarrier-dependent transportation represents an ideal method for confronting a broad range human disorders. study, we investigated possibility improving selective release anti-cancer paclitaxel (PTX) in gastro-intestinal tract by encapsulating it into biodegradable nanoparticles made FDA-approved poly(lactic-co-glycolic acid) (PLGA) and coated with polyethylene glycol to improve their...
Selectively targeted nanoscale drug delivery systems have recently emerged as promising intravenously therapeutic option for most chronic joint diseases. Here, a newly synthetized dodecapeptide (GE11)-polylactide-
The aim was to design sterile biodegradable microparticulate drug delivery systems based on poly(dl-lactide) (PLA) and poly(ɛ-caprolactone) (PCL) containing ivermectin (IVM), an antiparasitic drug, for subcutaneous administration in dogs. system should: (i) ensure a full 12-month protection upon single dose administration; (ii) be safe with particular attention regarding IVM dosage its release, order prevent over side effects. This preliminary work involves: polymer selection, evaluation of...
Background: Smart nanoparticulate materials, namely tailored nanoparticles (NPs) with specific surface functionality, have recently attracted attention as useful tool for time- and site-specific drug delivery. Specifically, polymeric can be chemically functionalized different chemical entities, i.e. peptides, that selectively recognize biological substrates in vivo target release. Divergent very complex strategies pursued order to obtain peptidedecorated NPs. Methods: A simple method was...