A5060906120- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Nuclear Structure and Function
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Plant Virus Research Studies
- RNA Research and Splicing
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Interference and Gene Delivery
- Transgenic Plants and Applications
- Mangiferin and Mango Extracts
- Respiratory viral infections research
- Peroxisome Proliferator-Activated Receptors
- Ginseng Biological Effects and Applications
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- vaccines and immunoinformatics approaches
- Herpesvirus Infections and Treatments
Jiangsu Agri-animal Husbandry Vocational College
2024-2025
Hunan Agricultural University
2015-2024
Augusta University
2015-2020
Georgia Regents Medical Center
2015
Mutations in BSCL2/SEIPIN cause Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), but the mechanisms whereby Bscl2 regulates adipose tissue function are unclear. Here, we generated (mature) knockout (Ad-mKO) mice, which was specifically ablated adipocytes of adult animals, to investigate impact acquired deletion on and energy balance. Ad-mKO mice displayed reduced adiposity were protected against high fat diet-induced obesity, not insulin resistance or hepatic steatosis. Gene...
Mutations in the BSCL2 gene underlie human type 2 Berardinelli-Seip congenital lipodystrophy (BSCL2) disease. Global Bscl2–/– mice recapitulate and results development of insulin resistance hypertrophic cardiomyopathy. The pathological mechanisms underlying cardiomyopathy are controversial. Here we report that develop cardiac hypertrophy because increased basal IGF1 receptor–mediated (IGF1R-mediated) PI3K/AKT signaling. hearts exhibited adipose triglyceride lipase (ATGL) protein stability...
The continuously evolving PRRSV has been plaguing pig farms worldwide for over 30 years, with conventional vaccines suffering from insufficient protection and biosecurity risks. To address these challenges, we identified 10 PRRSV-specific CTL epitopes through enzyme-linked immunospot assay (ELISPOT) constructed a multi-epitope peptide (PTE) by linking them in tandem. This PTE was then fused modified porcine Fc molecule to create the recombinant protein pFc-PTE. Our findings indicate that...
The capsid protein (Cap) is the sole structural and main antigen of porcine circovirus type 2 (PCV2). Structural loops Cap play crucial roles in viral genome packaging, assembly, virus-host interactions. Although molecular mechanisms are yet unknown, carboxyl terminus (CT) PCV2 known to critical evolution, pathogenesis, proliferation this virus. In study, we investigated functions CT. Removal loop leads abrogation vitro self-assembly into virus-like particles (VLPs). Likewise, mutated virus...
To explore the in vivo anti-obesity effect of chikusetsusaponin V and underlying mechanism by transcriptomic metabonomic methods.
Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that infect pigs' intestinal epithelial cells, causing high morbidity and mortality. Due to the rapid mutation of PEDV, vaccine efficacy uncertain, prompting exploration alternative treatments. Nanobodies, also known as variable heavy chain domains chain-only antibodies (VHHs), offer significant potential in biomedical applications due their small size specificity. In this study, yeast two-hybrid technology was...
Porcine reproductive and respiratory syndrome virus (PRRSV) causes disorders in sows severe pneumonia piglets, alongside immunosuppressive effects on the host. It poses a significant global threat to swine industry, with no effective control measures currently available due its complex pathogenesis high variability. Conventional inactivated attenuated vaccines provide inadequate protection carry biosafety risks. In this study, we designed universal multi-epitope peptide vaccine against PRRSV...