A5017786098- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Automotive and Human Injury Biomechanics
- Cardiac Arrest and Resuscitation
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Extracellular vesicles in disease
- Nerve injury and regeneration
- Neonatal and fetal brain pathology
- S100 Proteins and Annexins
- Neurological disorders and treatments
- Cell Image Analysis Techniques
- Space Exploration and Technology
- Cerebral Palsy and Movement Disorders
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Pluripotent Stem Cells Research
- Immune Response and Inflammation
- Winter Sports Injuries and Performance
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
University of Pennsylvania
2017-2024
Philadelphia VA Medical Center
2017-2024
Drexel University
2017-2019
Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI); however, the role hippocampus cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional structural changes swine following TBI using model head rotational acceleration that closely replicates biomechanics neuropathology closed-head humans. examined neurophysiological novel ex vivo hippocampal slice paradigm with extracellular...
Reestablishing cerebral connectivity is a critical part of restoring neuronal network integrity and brain function after trauma, stroke, neurodegenerative diseases. Creating transplantable axon tracts in the laboratory an unexplored strategy for overcoming common barriers limiting regeneration vivo, including growth-inhibiting factors limited outgrowth capacity mature neurons brain. We describe generation, phenotype, constrained three-dimensional human derived from organoids. These...
Abstract Although human females appear be at a higher risk of concussion and suffer worse outcomes than males, underlying mechanisms remain unclear. With increasing recognition that damage to white matter axons is key pathologic substrate concussion, we used clinically relevant swine model explore potential sex differences in the extent axonal pathologies. At 24 h post-injury, female displayed greater number swollen profiles more widespread loss sodium channels males. Axon degeneration for...
Abstract Monocyte‐derived macrophages play a critical role in directing wound pathology following injury. Depending on their phenotype, also promote tissue regeneration. However, the therapeutic administration of with controlled phenotype is challenging because are highly plastic and quickly revert to detrimental, inflammatory response environment damaged tissue. To address this issue, we developed novel strategy modulate macrophage intracellularly through phagocytosis drug‐loaded...
Over 2.8 million people experience mild traumatic brain injury (TBI) in the United States each year, which may lead to long-term neurological dysfunction. The mechanical forces that are caused by TBI propagate through produce diffuse axonal (DAI) and trigger secondary neuroinflammatory cascades. cascades persist from acute chronic time points after injury, altering homeostasis of brain. However, relationship between hallmark pathology potential changes glial cell activation or morphology...
Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits. The dentate gyrus of hippocampus is notably susceptible to damage following TBI, as hilar mossy cell changes particular may contribute post-TBI dysfunction. Moreover, microglial activation after TBI play a role hippocampal circuit and/or synaptic remodeling; however, potential effects chronic are currently unknown. objective current study was assess...
Closed-head traumatic brain injury (TBI) is induced by rapid motion of the head, resulting in diffuse strain fields throughout brain. The mechanism(s), loading thresholds, and neuroanatomical distribution affected cells remain poorly understood, especially gyrencephalic We utilized a porcine model to explore relationships between head rotational acceleration-deceleration immediate alterations plasmalemmal permeability within cerebral cortex, sub-cortical white matter, hippocampus. To assess...
Parkinson's disease (PD) affects 1-2% of people over 65, causing significant morbidity across a progressive course. The classic PD motor deficits are caused by the degeneration dopaminergic neurons in substantia nigra pars compacta (SNpc), resulting loss their long-distance axonal projections that modulate striatal output. While contemporary treatments temporarily alleviate symptoms this disconnection, there is no approach able to replace nigrostriatal pathway. We applied microtissue...
Head impact sensors measure head kinematics in sports, and sensor accuracy is crucial for investigating the potential link between repetitive loading clinical outcomes. Many validation studies mount to human surrogates compare kinematic measures during from a linear impactor. These are often unable distinguish intrinsic instrumentation limitations variability caused by coupling. The aim of current study was evaluate error angular velocity absence coupling common sensor. Two Triax SIM-G were...
Abstract Mild traumatic brain injury affects millions of individuals annually primarily through falls, traffic collisions, or blunt trauma and can generate symptoms that persist for years. Closed-head rotational loading is the most common cause mild defined by a rapid acceleration tissue within an intact skull. Injury kinematics—the mechanical descriptors injury-inducing motion—explain movement head, which govern energy transfer, and, therefore, determine severity. However, relationship...
Abstract Traumatic brain injury (TBI) is a global health problem affecting millions of individuals annually, potentially resulting in persistent neuropathology, chronic neurological deficits, and death. However, TBI not only affects neural tissue, but also the peripheral immune system’s homeostasis physiology. disrupts balanced signaling between organs, immunodysregulation increasing infection susceptibility. Indeed, secondary infections following worsen outcomes are major source mortality...
ABSTRACT Mild traumatic brain injury (mTBI) affects millions of individuals annually primarily through falls, traffic collisions, or blunt trauma and can generate symptoms that persist for years. Closed-head rotational is the most common form mTBI defined by a rapid change in acceleration within an intact skull. Injury kinematics – mechanical descriptors injury-inducing motion explain movement head, energy transfer to brain, and, therefore, determine severity. However, relationship between...
Summary Reestablishing cerebral connectivity is a critical part of restoring neuronal network integrity and brain function after trauma, stroke, neurodegenerative diseases. Creating transplantable axon tracts in the laboratory novel strategy for overcoming common barriers limiting regeneration vivo , including growth-inhibiting factors limited outgrowth capacity mature neurons brain. We describe generation phenotype three-dimensional human derived from organoid tissue. These centimeter-long...
Reestablishing cerebral connectivity is a critical part of restoring neuronal network integrity and brain function after trauma, stroke, neurodegenerative diseases. Creating transplantable axon tracts in the laboratory novel strategy for overcoming common barriers limiting regeneration vivo, including growth-inhibiting factors limited outgrowth capacity mature neurons brain. We describe generation phenotype three-dimensional human derived from organoid tissue. These centimeter-long...
Abstract Over 2.8 million people experience mild traumatic brain injury (TBI) in the United States each year, which may lead to long-term neurological dysfunction. The mechanical forces that occur due TBI propagate through produce diffuse axonal (DAI) and trigger secondary neuroinflammatory cascades. cascades persist from acute chronic time points after injury, altering homeostasis of brain. However, relationship between hallmark pathology potential changes glial cell activation or...
ABSTRACT Monocyte-derived macrophages orchestrate tissue regeneration by homing to sites of injury, phagocytosing pathological debris, and stimulating other cell types repair the tissue. Accordingly, monocytes have been investigated as a translational potent source for therapy, but their utility has hampered rapid acquisition pro-inflammatory phenotype in response inflammatory injury microenvironment. To overcome this problem, we designed therapy strategy where collect exogenously reprogram...