Xiaoru Fan

ORCID: 0000-0002-0395-3400
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About
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Research Areas
  • Plant nutrient uptake and metabolism
  • Plant Molecular Biology Research
  • Platelet Disorders and Treatments
  • Rice Cultivation and Yield Improvement
  • Legume Nitrogen Fixing Symbiosis
  • Advanced Data Storage Technologies
  • Soil Carbon and Nitrogen Dynamics
  • Plant Micronutrient Interactions and Effects
  • Extracellular vesicles in disease
  • Chromosomal and Genetic Variations
  • Immune cells in cancer
  • Plant tissue culture and regeneration
  • Crop Yield and Soil Fertility
  • Plant-derived Lignans Synthesis and Bioactivity
  • Galectins and Cancer Biology
  • Plant Stress Responses and Tolerance
  • Genetic Mapping and Diversity in Plants and Animals
  • Phosphorus and nutrient management
  • Autoimmune Bullous Skin Diseases
  • Natural Antidiabetic Agents Studies
  • Cell Adhesion Molecules Research
  • Agriculture Sustainability and Environmental Impact
  • Soil and Water Nutrient Dynamics
  • Blood groups and transfusion
  • Natural product bioactivities and synthesis

Anshan Normal University
2021-2023

South China Agricultural University
2021-2023

Nanjing Agricultural University
2007-2021

Soochow University
2020-2021

Peking Union Medical College Hospital
2012

Chinese Academy of Medical Sciences & Peking Union Medical College
2012

The nitrate (NO3-) transporter has been selected as an important gene maker in the process of environmental adoption rice cultivars. In this work, we transferred another native OsNAR2.1 promoter with driving into plants. transgenic lines exogenous pOsNAR2.1:OsNAR2.1 constructs showed enhanced expression level, compared wild type (WT), and

10.1111/pbi.12714 article EN cc-by Plant Biotechnology Journal 2017-02-22

Background and AimsThere is increased evidence that partial nitrate (NO3−) nutrition (PNN) improves growth of rice (Oryza sativa), although the crop prefers ammonium (NH4+) to NO3− nutrition. It not known whether response supply related nitrogen (N) use efficiency (NUE) in cultivars.

10.1093/aob/mcm051 article EN Annals of Botany 2007-01-26

The NO3- transporter plays an important role in rice nitrogen acquisition and nitrogen-use efficiency. Our previous studies have shown that the high affinity systems for nitrate uptake is mediated by a two-component NRT2/NAR2 transport system. In this study, transgenic plants were successfully developed overexpression of OsNAR2.1 alone, OsNRT2.3a alone co-overexpression OsNRT2.3a. our field experiments, lines expressing p35S:OsNAR2.1 or p35S:OsNAR2.1-p35S:OsNRT2.3a constructs exhibited...

10.3389/fpls.2020.01245 article EN cc-by Frontiers in Plant Science 2020-08-12

Drought is an important environmental factor that severely restricts crop production. The high-affinity nitrate transporter partner protein OsNAR2.1 plays essential role in absorption and translocation rice. Our results suggest expression markedly induced by water deficit. After drought stress conditions irrigation, compared with wild-type (WT), the survival rate was significantly improved over-expression lines decreased RNAi lines. of Wuyunjing7 (WYJ), OsNRT2.1 OsNRT2.3a not different....

10.3389/fpls.2019.00197 article EN cc-by Frontiers in Plant Science 2019-02-20

Background Immune imbalance of regulatory T cells (Treg)/T helper 17 (Th17) contributes to the development immune thrombocytopenic purpura (ITP). The dysregulation miRNAs is important in ITP. However, role miR-106b-5p Treg/Th17 remains unknown ITP.Materials and methods Peripheral blood was collected from patients with ITP healthy controls, CD4 + were further isolated. miR-106b-5p, nuclear receptor subfamily 4 group A member 3 (NR4A3), forkhead box protein (Foxp3), IL-17A, TGF-β expressions...

10.1080/15384101.2020.1746485 article EN Cell Cycle 2020-04-23

Synthetic nitrogen fertilizer substitution (NSS) with different types of organic material is a cleaner agricultural practice for reducing the application synthetic N input in farmlands while also relieving environmental issues caused by discharge wastes. However, effects NSS on crop yields, being primary objective activity, still uncertain China. This study conducted meta-analysis to assess impacts practices materials yields. Results showed that average yield was increased 3.4%, significant...

10.3390/agronomy11122429 article EN cc-by Agronomy 2021-11-28

Climate change negatively affects crop yield, which hinders efforts to reach agricultural sustainability and food security. Here, we show that a previously unidentified allele of the nitrate transporter gene OsNRT2.3 is required maintain high yield nitrogen use efficiency under temperatures. We demonstrate this tolerance temperatures in rice accessions harboring HTNE-2 (high temperature resistant efficient-2) alleles from enhanced translation OsNRT2.3b mRNA isoform decreased abundance unique...

10.1126/sciadv.adc9785 article EN cc-by-nc Science Advances 2022-11-23

Transgenic technologies have been applied to a wide range of biological research. However, information on the potential epigenetic effects transgenic technology is still lacking. Here, we show that process can simultaneously induce both genetic and changes in rice. We analyzed genetic, epigenetic, phenotypic plants subjected tissue culture regeneration, using lines expressing same coding sequence from two different promoters rice cultivars: Wuyunjing7 (WYJ7) Nipponbare (NP). determined...

10.3390/ijms21051819 article EN International Journal of Molecular Sciences 2020-03-06

Abstract Background Nitrogen (N) is an important nutrient for plant growth, development, and agricultural production. stress could induce epigenetic changes in plants. In our research, overexpression of the OsNAR2.1 line was used as a testing target rice plants with high nitrogen-use efficiency to study methylation growth respond endogenous external nitrogen stress. Results Our results showed that N deficiency decrease seed content line. During filial we found low parent (LPSN) lead content,...

10.1186/s12870-021-02953-3 article EN cc-by BMC Plant Biology 2021-05-11

The studies of rice nitrogen concentration on the expression miRNA so far are mostly limited to exogenous nitrogen, leaving effect endogenous largely unexplored. OsNAR2.1 is a high-affinity nitrate transporter partner protein which plays central role in absorption and translocation rice. could influence We showed that production can be influenced by manipulating via transgenic lines. small RNA content, particularly 24 nucleotides RNA, expressed differently two lines (nitrogen efficient line...

10.3389/fpls.2023.1093676 article EN cc-by Frontiers in Plant Science 2023-02-24

Background: Immune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder and the decreased number immunosuppressive dysfunction of Treg cells are key promoters ITP. However, their mechanisms in ITP development have not been fully clarified. Methods: HUWE1 mRNA protein levels CD4+ T peripheral blood from patients were assessed by quantitative real-time PCR Western blot. function was estimated using flow cytometry, enzyme-linked immunosorbent assay immunosuppression assay. Besides,...

10.3389/fcell.2021.708562 article EN cc-by Frontiers in Cell and Developmental Biology 2021-11-25
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