A5087639267- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Fibroblast Growth Factor Research
- Wound Healing and Treatments
- Kruppel-like factors research
- Connective Tissue Growth Factor Research
- Biochemical Analysis and Sensing Techniques
- Bee Products Chemical Analysis
- Acne and Rosacea Treatments and Effects
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Skin Protection and Aging
- Autoimmune Bullous Skin Diseases
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Laser Applications in Dentistry and Medicine
- Advanced biosensing and bioanalysis techniques
- Liver physiology and pathology
- Photodynamic Therapy Research Studies
- Facial Rejuvenation and Surgery Techniques
- Wnt/β-catenin signaling in development and cancer
- Immunotherapy and Immune Responses
- Skin and Cellular Biology Research
- Coronary Interventions and Diagnostics
- Dermatological and Skeletal Disorders
Yanbian University Hospital
2011-2025
Chinese Medical Association
2024-2025
Yanbian University
2013-2022
The pathogenesis of keloid is complex and unclear, current therapies this condition remain unsatisfactory. Dehydroepiandrosterone (DHEA), a steroid prohormone, exhibits wide range pharmacologic activities, including anti-inflammatory pro-immune effects, as well anti-tumor anti-fibrotic properties. Herein, the authors explored potential effects underlying mechanisms DHEA on fibroblasts in vitro. authors' findings indicated that significantly inhibited proliferation, migration, invasion...
Twenty-seven compounds including nine triterpenoids (1–9), eight sterols (10–17), two ribonucleotides (18, 19), four phenols (20–23), three glycosides (24–26), and one furan (27) were isolated from the fruiting bodies of Trametes versicolor (L.) Lloyd. This study is first confirmation presence 11 (3, 5, 6, 8, 18, 20, 21, 23–25, 27) Polyporaceae family, with six these (2 12–16) genus Trametes. Compounds 3, 4, 10, 11, 16 17 found to significantly inhibit production NO, TNF-α IL-6 in a...
Keloid (KD) is a unique pathological fibroproliferative disease that seriously affects the appearance of patients. This study investigated effect oleanolic acid (OA) on proliferation keloid fibroblasts (KFs) and expression extracellular matrix (ECM)-related proteins.The KFs was evaluated using an MTT assay. The effects OA intra- levels fibronectin (FN), procollagen I, metalloproteinase-1 (MMP-1), α-smooth muscle actin (α-SMA) were Western blotting. To simulate KD microenvironment, TGF-β1...
Accumulating evidence indicated that aberrantly expressed microRNAs play critical roles in the initiation and progression of human cancers. However, underlying functions miR-493 melanoma remains unknown. Here, our study found expression was downregulated tissues cells. Overexpression suppressed cell proliferation cycle line A375. IRS4 defined as a target for downregulation by confirmed luciferase assay. We also knockdown counteracted promotion inhibitor. In summary, these results...
Abstract Background Keloid is a benign fibro-proliferative dermal tumor formed by an abnormal scarring response to injury and characterized excessive collagen accumulation invasive growth. The mechanism of keloid formation has not been fully elucidated, especially during scarring. Here, we investigated the regulatory genes, micro-RNAs (miRNAs) transcription factors (TFs) that influence development comparing normal scar as well skin. Methods Gene expression profiles (GSE7890, GSE92566,...
A keloid is a benign tumor manifested as abnormal fibroplasia on the surface of skin. Curing keloids has become major clinical challenge, and searching for new treatments medications critical. In this study, we developed LA67 liposome-loaded thermo-sensitive hydrogel (LA67-RL-Gel) with active targeting treating via peritumoral injection explored anti-keloid mechanism. Firstly, Arg-Gly-Asp (RGD) peptide-modified liposomes (LA67-RL) loaded were prepared particle size 105.9 nm Zeta potential...
Rosacea is a prevalent chronic dermatological condition marked by facial inflammation and erythema, significantly compromising the quality of life for affected individuals. Current treatment methods rosacea are not considered ideal because complex etiology disease. Mussel adhesive protein (MAP) glycoprotein derived from foot gland mussels. The exhibits anti-inflammatory properties, relieves skin itching, promotes wound healing.
Keloid is the result of abnormal wound healing, puzzled by invasive growth and high recurrence rate attributed to its complex pathogenic mechanism. Syndecan1 (SDC1) contributes regulating cell migration invasion activating epithelial-mesenchymal transition (EMT) in tumor fibrotic disease. Herein, using western blot analysis, authors assessed role SDC1 on EMT keloid underlying The found fibroblasts exhibited a higher proportion mesenchymal phenotypes, was significantly upregulated...
Purpose: Several studies have compared the effects of coronary stenting and coronary-artery bypass grafting (CABG) on left main artery (LMCA) disease.However, there are limited data long-term outcomes these two interventions in diabetic patients.Materials Methods: We evaluated 56 patients with LMCA stenosis who underwent drug-eluting stent (DES) implantation 116 CABG a single hospital China between January 2004 December 2006.We major adverse cardiac events (death; "serious outcome" composite...
Melanocytes are generally characterized by the basic ability of melanin synthesis and transfer to adjacent keratinocytes. This constitutes an individual skin phenotype provides epidermal protection from various stimuli, such as ultraviolet irradiation, through a complex process called melanogenesis, which can be regulated autocrine or paracrine factors. Recent evidence has revealed effects keratinocytes on melanogenesis secreting cytokines, including α‐melanocyte stimulating hormone...
Numerous researches have focused on discovering available inhibitors of melanogenesis from natural medicinal plants with stable efficacy and safety to resolve cutaneous hyperpigmentary problems. Melochia corchorifolia Linn. (MC) has been used as folk medicine treat various diseases. However, the effect MC remains unknown.In this study, we investigated extract its underlying mechanisms in B16F10 mouse melanoma cells.B16F10 cells were treated extract, then, cell viability, melanin content,...
Keloid is a benign proliferative fibrous disease featured by excessive fibroblast proliferation after skin injury. However, the mechanism of abnormal cell still unclear. Herein, we investigated in keloids involving Sirtuin 1(SIRT1)/ Zeste Homolog 2 (EZH2)/ Runt-related transcription factor 3 (RUNX3). METHODS: HE staining was used to observe histopathological changes. Western blot performed detect SIRT1/EZH2/RUNX3 and cycle related proteins. RT-PCR detected EZH2 mRNA. After knockdown or...
Background/Aim: Regulatory functions of amyloid precursor-like protein 2 (APLP2) expression in intracellular trafficking major histocompatibility complex class I (MHC-I) and biological behavior tumor cells have been reported various types malignancies but not cutaneous squamous cell carcinoma (CSCC). This study aimed to investigate the role APLP2 pathogenesis CSCC. Patients Methods: The a key modulator cancer immune escape, MHC-I, were determined CSCC tissue samples obtained from 141...
Rosacea is a chronic inflammatory skin disease affecting the face, and current treatment effect not satisfactory. Based on photomodulation of optimal pulse technology (OPT), we developed novel mode, namely, advanced OPT with low energy, three pulses, long width (AOPT-LTL).We aimed to explore feasibility underlying molecular mechanisms AOPT-LTL in rosacea-like mouse model. Furthermore, evaluated safety efficacy patients erythematotelangiectatic rosacea (ETR).Morphological, histological,...
Objective: In vitro comparison of chondrogenic differentiation ability bone marrow extracted mesenchymal stem cells (MSCs) and buffy coat. Methods: MSCs New Zealand white rabbits were cultured in adherent passaged. The inoculated on polyglycolic acid (PGA) scaffold (3 mm diameter 2 height) liquid for 21 days. Under the same conditions, without subculture, coat was directly into cell scaffold. degree compared by Safranin-Ostaining, histological scoring biochemical functional detection....
Cutaneous squamous cell carcinoma (cSCC) is a common non-melanoma skin cancer, and its incidence increasing. Proteasome subunit alpha type-7 (PSMA7) has been found to be aberrantly expressed in several cancers. However, whether it functions as tumor suppressor or oncogene the pathogenesis of cancers, particularly cSCC, remains controversial. Here, we aimed investigate PSMA7 cSCC pathogenesis.Clinicopathological characteristics were evaluated 131 patients with using tissue sections. The...
Filling therapy is becoming increasingly popular for correcting tear trough deformities (TTD). However, its therapeutic effect and retention time are limited.