A5029871759- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Iron Metabolism and Disorders
- Galectins and Cancer Biology
- Hemoglobinopathies and Related Disorders
- Liver Disease Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cancer, Lipids, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Phagocytosis and Immune Regulation
- Acute Myeloid Leukemia Research
- Bladder and Urothelial Cancer Treatments
- Nuclear Receptors and Signaling
- Global Cancer Incidence and Screening
- Platelet Disorders and Treatments
- Multiple Myeloma Research and Treatments
- Paraoxonase enzyme and polymorphisms
- Wnt/β-catenin signaling in development and cancer
- Gastric Cancer Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Pomegranate: compositions and health benefits
- Blood donation and transfusion practices
Mazandaran University of Medical Sciences
2015-2024
Imam Khomeini Hospital
2009-2023
Cancer Research Center
2015-2022
University of Mazandaran
2019
Tehran University of Medical Sciences
2009
Abstract Objectives The phenotypic and functional properties of Tim‐3 + / PD ‐1 CD 8 cells as exhausted T were investigated in chronic lymphocytic leukemia ( CLL ). Methods Frequency /Tim‐3 was determined by flow cytometry. For analysis, magnetic beads‐isolated stimulated with PHA PMA /ionocymin to assess their proliferative responses cytokine production MTT ELISA , respectively. Cytotoxic activity isolated using 107a degranulation assay. Results proportion significantly higher compared...
Background: Deviation of host immune response by engagement inhibitory receptors is one the well-known mechanisms tumor cells for evasion and survival. PD-1/PD-L1 Tim-3/Gal-9 axes are two major pathways in this area which their contribution has been documented a variety malignancies. In study, Gal-9 PD-L1 expression was investigated leukemic from patients with Chronic Lymphocytic Leukemia (CLL). Methods: Peripheral blood mononuclear (PBMCs) were obtained 25 untreated CLL 15 sex- age-matched...
Introduction. β-Thalassaemia is the most common genetic disorder and considered as a major public health concern in Iran. Different countrywide studies have shown heterogeneous mutational basis of β-thalassaemia with different frequencies each area. This study aimed at investigating rare mutations Mazandaran Golestan, northern provinces Methods. 5425 microcytic hypochromic individuals were investigated from Golestan provinces. From these, 1323 beta carrier or affected selected where 938...
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant cancer treatment side effect that can influence both quality of life and course. Melissa Officinalis (MO), due to its high content flavonoids, has antioxidant, anti-inflammatory, neuroprotective properties. Materials Methods: The patients diagnosed with CIPN attended referral center in Sari (Iran). hydroalcoholic extract MO leaves was extracted by the maceration method. control group received placebo along...
To determine the expression of cancer stem cell marker Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) in colorectal carcinoma samples compared to normal adjacent tissue and any possible association with clinicopathological findings.This study was performed on forty cancerous tissues (case group) their mucosa (control Imam Khomeini Hospital (Sari, Mazandaran, Iran). Expression Lgr5 sections done by immunohistochemistry. Statistical analysis carried out using SPSS...
Blockade of immune checkpoint receptors in the treatment cancers has been mentioned several studies. Here, we investigated efficacy combined blockade two inhibitory receptors, PD-1 and TIGIT, restoring functional features CD8+ T-cells CLL.CD8+ were separated from peripheral blood 11 CLL patients targeted with malignant B-cells isolated same patients. Cells then stimulated anti-CD3/CD28 PMA/ionomycin to assess their proliferative response cytotoxic activity using MTT CD107a degranulation...
Background: Several studies have demonstrated roles of interleukins in the pathogenesis multiple myeloma (MM). Objective: Here we considered correlations among serum levels IL-10, stage disease and clinical laboratory markers Iranian MM patients to investigate whether interleukin might prognostic significance. Materials Methods: In this cross-sectional study, a total 60 subjects (40 20 controls) were recruited. After preliminary tests, was evaluated IL-10 measured using an enzymelinked...
Toxoplasmosis is highly prevalent in northern Iran and immunocompromised individuals are more susceptible to this infection. The present study aimed determine the seroprevalence, parasitism genetic diversity of Toxoplasma gondii among patients with cancer undergoing chemotherapy Iran.A total 350 serum samples obtained from were collected laboratory centers Iran. Immunodiagnosis DNA detection accomplished by ELISA PCR. Thereafter, multiplex-nested PCR-restriction fragment length polymorphism...
Abstract Gastric cancer (GC) is one of the most prevalent cancers and a major cause related mortality worldwide. Incidence GC affected by various factors, including genetic environmental factors. Despite extensive research has been done for molecular characterization GC, it remains largely unknown. Therefore, further studies specially conducted among ethnicities in different geographic locations, are required to know precise mechanisms leading tumorigenesis progression GC. The expression...
This study was designed to determine relationship between the glucose metabolism disorder (the insulin resistance and impaired tolerance) α-thalassemia.In this historical cohort study, 80Alpha-thalassemia carriers 80 healthy people were enrolled. The participants had no diabetes familial history waist circumference blood pressure in normal range (waist of less than 102 cm men, 88 women <120/80 mmHg). serum level, fasting (after 12 hours fasting) two-hour plasma during an oral tolerance test...
Programmed death-1 (PD-1) and T-cell immunoglobulin- mucin-domain-containing molecule-3 (Tim-3) are two major immune checkpoint receptors expressed on cells their expression is related to the exhaustion phenotype. In present in vitro study, blocking of PD-1 Tim-3 molecules was performed isolated natural killer (NK) from patients with chronic lymphocytic leukemia (CLL) restore functional properties.NK fraction positively fresh peripheral blood 18 CLL patients, treated anti-PD-1 anti-Tim-3...
The role of immune checkpoint receptors in T-cell exhaustion has been demonstrated several cancers. We investigated the co-expression TIGIT/PD-1 and LAG-3/PD-1 cells patients with chronic lymphocytic leukemia (CLL). frequencies TIGIT+PD-1+CD8+and LAG-3+PD-1+CD8+cells relative mRNA expression LSECtin CD155 were examined PBMCs from 33 CLL 20 controls. percentage TIGIT+PD-1+CD8+cells was significantly higher than control subjects, preference advanced stage patients. However, LAG-3+PD-1+CD8+cell...
Thymocyte selection-associated high mobility group box protein (TOX) and members of the nuclear receptor 4A (NR4A) are known as transcription factors involved in T cell exhaustion.
The
This study aimed to investigate the impact of Free-fatty acid receptor-4 (FFAR4) rs61866610 polymorphism on colorectal cancer (CRC) risk. Herein, ninety-two histopathologically confirmed CRC patients and 95 healthy individuals were evaluated for FFAR4 by RFLP-PCR. Gender, age, body mass index (BMI), underlying disease, smoking status recorded all subjects. Clinical histopathologic findings including tumor grade TNM stage also prepared in patient group. Except type 2 diabetes which was more...
Purpose: Cancer is a most important disease, and female reproductive system cancers are the common cause of women mortality rate. Materials Methods: This cross-sectional study analyzed medical record data for 4460 patients in Mazandaran population-based cancer registry. Results: The mean (standard deviation) age these was 53.45 years, incidence rate (age-standardized rate) 8.51 per 100,000 persons-year. These incidences were more urban than rural, but this difference not significant....
Introduction: Urinary system malignancies are considered as one of the main public health concerns with high morbidity and mortality. These cancers have various patterns in different regions over time. This study aims to determine incidence these northern part Iran (Mazandaran Province). Materials Methods: cross-sectional carried out among patients urologic 2014. A population-based cancer registry Mazandaran University Medical Sciences was source information. Stata software version 14...