A5102878183- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Intraperitoneal and Appendiceal Malignancies
- Colorectal and Anal Carcinomas
- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Hip disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Anorectal Disease Treatments and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Signaling Pathways in Disease
- Total Knee Arthroplasty Outcomes
- Soft tissue tumor case studies
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Orthopaedic implants and arthroplasty
- Biochemical and Molecular Research
Chugoku Rosai Hospital
2020-2024
Higashihiroshima Medical Center
2013-2021
Hiroshima University
2013-2019
Hiroshima General Hospital
2015-2018
Futaba (Japan)
2015-2018
Life Science Institute
2015
Hiroshima University Hospital
2012
Funabashi Orthopaedic Hospital
2007-2008
Mutations in TGFBR2, a component of the transforming growth factor (TGF)-β signaling pathway, occur high-frequency microsatellite instability (MSI-H) colorectal cancer (CRC). In mouse models, Tgfbr2 inactivation intestinal epithelium accelerates development malignant tumors combination with disruption Wnt-β-catenin pathway. However, no studies have further identified genes influenced by TGFBR2 following We previously described CDX2P-G19Cre;Apcflox/flox mice, which is stochastically null for...
The gastrointestinal tract is continuously exposed to a variety of chemicals and commensal bacteria. Recent studies have shown that changes in gut microbial populations caused by chlorine or other the drinking water influence development human colorectal cancer, although mechanism tumorigenesis epithelium obfuscated diversity microflora complexity tumor microenvironment. In this regard, mouse models recapitulate cancer are an invaluable tool. study, we used two conditional adenomatous...
KRAS mutations occur in 30-40% of all cases human colorectal cancer (CRC). However, to date, specific therapeutic agents against KRAS-mutated CRC have not been developed. We previously described the generation mouse models colon with and without Kras (CDX2P-G22Cre;Apc(flox/flox); LSL-Kras(G12D) CDX2P-G22Cre;Apc(flox/flox) mice, respectively). Here, two were compared identify candidate genes, which may represent novel targets or predictive biomarkers. Differentially expressed genes tumors...
In stage IV colorectal cancer (CRC) with unresectable metastases, whether or not resection of the primary tumor should be indicated remains controversial. We aim to determine impact on survival CRC patients metastases.We retrospectively investigated 103 treated at Hiroshima University Hospital between 2007 and 2013. Of these, those who had resectable but metastases received any chemotherapy were included in study. analyzed overall (OS) short-term outcomes up-front systemic (USC group)...
Although synbiotics may be effective in maintaining remission of inflammatory bowel disease, their anticarcinogenic effects are still debated. To address this issue, we evaluated the synbiotics, probiotics, and prebiotics on tumorigenesis using a CDX2P-Cre; Apc+/flox mouse model harboring colon-specific Apc knock out, which develops adenoma adenocarcinoma colon. Dextran sodium sulfate (DSS)-administration promoted colonic tumor development mice, these tumors were associated with loss...
Renal cell carcinoma is well-known for its propensity to metastasize unusual sites. However, metastasis the gallbladder has been rarely reported in literature. A 75-year-old Japanese (Asian) woman presented further evaluation of a polyp, 15 years after right radical nephrectomy renal carcinoma. Computed tomography revealed 12 mm enhancing pedunculated tumor fundus. Open simple cholecystectomy was performed and histologically confirmed as gallbladder. Our patient alive disease-free 3...
Micropapillary carcinoma was originally reported to be an aggressive variant of breast carcinoma, and it is associated with frequent lymphovascular invasion a dismal clinical outcome. It has subsequently been found in other organs; however, at present, only limited number cases colorectal micropapillary have reported. We present case early colon cancer extensive nodal metastases Japanese patient. An 82-year-old man by colonoscopy 20-mm pedunculated polyp his sigmoid colon. Endoscopic...
Abstract BRAF V600E mutation accounts for up to 90% of all mutations in human colorectal cancer (CRC), and constitutively activates the MEK‐MAPK pathway. It is recognized that neutralizing mAbs epidermal growth factor receptor alone are not effective CRC with mutation. Therefore, there increasing interest identification possible therapeutic targets downstream CRCs. To address this, we studied genome engineered mouse models colonic neoplasia has Braf on basis Apc inactivation, induced 2...
The number of patients who have difficulty with mutual understanding has been increasing recently due to an aging society. This emerging issue needs be addressed. We report instructive case a patient had communication difficulties dementia and sequelae alcoholic encephalopathy. A 66-year-old man Mongolian race presented coronary arteriosclerosis, spinal canal stenosis, transverse colon cancer, requested remove wires that used for the closure his chest in artery bypass grafting procedure....
Anastomotic leakage is associated with severe morbidity, mortality, and functional defects. Its risk factors remain unclear. However, blood perfusion may be a potential major factor. It has been reported that the Agatston score an index for flow evaluation. Therefore, we evaluated clinical indicators anastomotic leakage, including score, in patients who underwent colorectal surgery.We retrospectively analyzed 147 elective surgery double-staple technique anastomosis cancer between April 2015...
Goblet cell adenocarcinoma of the appendix is a rare diagnosis with features both adenocarcinomas and carcinoid tumors. Commonly presenting chronic abdominal pain, appendicitis, or distention, it can also be incidentally discovered during appendectomies.
The number of patients with hiatal hernia has increased. Paraesophageal and mixed hernias are absolute indications for surgical treatment due to the possibility blood flow disturbances stomach other organs. A 77-year-old woman a history type IV esophageal (under observation), multiple operations presented chief complaint vomiting. She was diagnosed incarceration duodenal bulb into mediastinum. Although relieved conservative treatment, patient at high risk recurrence; therefore, repair...
Gastric cancer incidence is high in several countries, and management of advanced gastric remains a challenge. Chemotherapy for unresectable cancers still evolving, achieving complete cure difficult. Although clinical response to chemotherapy has been reported patients with cancer, the duration these unclear. Here, we report case 71-year-old man who presented abdominal discomfort. Upper endoscopy revealed on upper body. Histopathological examination poorly differentiated adenocarcinoma....
Alpha-fetoprotein (AFP) has been widely used as a tumor marker for detecting hepatocellular carcinoma and yolk sac tumors. Recently, cases of gastrointestinal cancer with elevated serum AFP levels have reported. However, AFP-producing colon is considered rarer than other cancers. In this study, we report on case 47-year-old woman who was diagnosed sigmoid underwent sigmoidectomy lymph node dissection. Postoperative adjuvant chemotherapy (AC) performed after the curative surgery. After...
Abstract Background Submucosal fecalith(s) mimicking submucosal tumors of the gastrointestinal lumen are rare. Moreover, accurate preoperative diagnosis these entities is exceedingly difficult, and mechanism(s) their formation remains unclear. Case presentation A 40-year-old woman visited authors’ hospital due to lower abdominal pain diarrhea. She had previously been treated for endometriosis. Laboratory investigation revealed increased C-reactive protein levels. Abdominal contrast-enhanced...