A5072845297- Radiopharmaceutical Chemistry and Applications
- Agricultural and Biological Research
- Cancer Research and Treatments
- Genetics, Bioinformatics, and Biomedical Research
- Digestive system and related health
- Medical Imaging Techniques and Applications
- Estrogen and related hormone effects
- Tannin, Tannase and Anticancer Activities
- Enzyme Production and Characterization
- Orthopedic Infections and Treatments
- Glycosylation and Glycoproteins Research
- Mass Spectrometry Techniques and Applications
- Computational Drug Discovery Methods
- Radiation Therapy and Dosimetry
- Cancer Research and Treatment
- Cancer and biochemical research
- Medicinal Plant Research
- Machine Learning in Bioinformatics
- Biological Research and Disease Studies
- Machine Learning in Materials Science
- Enzyme Structure and Function
- Nuclear Physics and Applications
- Nanoparticle-Based Drug Delivery
- Inflammatory mediators and NSAID effects
- Retinoids in leukemia and cellular processes
National Nuclear Energy Agency of Indonesia
2009-2024
National Research and Innovation Agency
2023-2024
Indonesian Institute of Sciences
2024
Nuclear Energy Agency
2017
University of Indonesia
2014
Context: The development of radiopharmaceuticals derived from natural compounds has been extensively studied, particularly for cancer treatment. α-Mangostin is a molecule claimed to be toxic cells, and its derivative, an organometallic compound, synthesized successfully, namely bis-(α-mangostin)-cobalt(II) or AM-Co. AM-Co structure shows promise as radiopharmaceutical candidate, especially when labelled with radioactive iodine. Aims: To optimise the radiolabelling conditions iodine-131...
The International Atomic Energy Agency organized a technical meeting at its headquarters in Vienna, Austria, 2022 that included 17 experts representing 12 countries, whose research spanned the development and use of radiolabeled agents for imaging infection. focused largely on bacterial pathogens. group discussed evaluated advantages disadvantages several radiopharmaceuticals, as well science driving various approaches. main objective was to understand why few infection-targeted radiotracers...
Sulochrin is known to have an activity as inhibitors of the α-glucosidase enzyme. In this report interaction sulochrin active site enzyme from Saccharomyces cerevisiae was studied by docking method. The crystal structure S. obtained homology method using (Swiss-Prot code P53341) a target and isomaltase (PDB 3A4A) template. These studies show that sulochrin-I could be bound in through formation hydrogen bonds with Arg213, Asp215, Glu277, Asp352. Sulochrin-I has stability inhibition better...
Bone metastases are a common condition occurred at the end stage of prostate and breast cancer patients. Bonepain palliation radiopharmaceutical based on ethylenediamine tetra(methylene phosphonic acid) (EDTMP) ligand has been proven to effectively treat bone improve patients' quality life. In this report, formulation freeze-dried EDTMP kits for convenient preparation 153Sm-EDTMP subsequent control were described. Lyophilized produced employing EDTMP, NaOH, CaCO3. Important parameters such...
Oil palm (Elaeis guineensis Jacq.) leaves and empty fruit bunches (OPLEFB) extracts have secondary metabolites that the potential for green synthesis of Fe3O4 nanoparticles (NPs). The inquiry about strategy starts with extraction OPLEFB, NPs a various calcination temperatures 300, 400, 500 °C, conjugation Human Serum Albumin (HSA) ratio (1:1, 1:2, 1:3), labeling HSA-Fe3O4 Technetium-99m (99mTc). characterizations carried out were FT-IR, VSM, XRD. Conjugate characterization was seen utilizing...
Research was carried out to obtain a selective ligand which strongly bind estrogen receptors through determination of binding affinity estradiol-17β-hemisuccinate. Selectivity these compounds for receptor studied using Scintillation Proximity Assay (SPA) method. Primary reagents required in the SPA method including radioligand and receptor, former obtained by labeling estradiol-17β-hemisuccinate with 125 I, while MCF7 used as receptor. The process performed indirect via two-stage reaction....
The prevalence of cancer in Indonesia is increasing and various treatments still have shortcomings, recurrence occurs. Lymphoscintigraphy a method for detecting disorders the lymphatic system, which are closely related to cells. Human serum albumin nanocolloid as lymphoscintigraphic agent consists particles measuring
Prostate Specific Antigen (PSA) is a glycoprotein with molecular weight of approximately 34,000 daltons serine protease secreted exclusively by prostatic epithelial cells that lining acini and prostate gland. Increased PSA levels can be caused cancer or benign enlargement (benign hyperplasia, BPH). in the blood was found free condition (free PSA) most bound protein (complexed-PSA, c-PSA). Measuring done several methods such as immunoradiometricassay (IRMA) ELISA methods. IRMA method one...
Most of diabetes patients have type 2 mellitus or non insulin dependent mellitus. Treatment can be conducted by inhibiting the α-glucosidase enzyme which converts carbohydrates into glucose. Sulochrin is one potential compounds inhibit function enzyme. This study was carried out to obtain data sulochrin binding with as inhibitor using Radioligand Binding Assay (RBA) method. The primary reagent required in RBA labeled radioactive ligand ( radioligand). In this study, radioligand sulochrin-...
OPTIMASI PEMBUATAN COATED TUBE HUMAN SERUM ALBUMIN (HSA) UNTUK KIT RADIOIMMUNOASSAY (RIA) MIKROAMBUMIN. Radioimmunoassay adalah suatu metoda analisis berdasarkan pada reaksi imunologi yakni ikatan antigen-antibodi, ini sangat spesifik dan peka digunakan untuk menentukan kadar zat-zat yang ada di dalam cairan tubuh seperti serum, urine lainnya sehingga dapat mengevaluasi penyakit metabolik diabetes melitus. Penelitian pengembangan teknologi Kit RIA mikroalbuminuria dengan metode coated tube...
A model of 125 I -phalerin was designed in this research. The work started by designing phalerin based on available data and followed minimizing energy at bond angles, i.e C4-05-C7-C8 (0 ) , C5-C7-C8-C9 (2),C3-014-C15-C20 (3) C4-C3-014-C15 (4).This then continued with 115l -phalerin. Both models were put overlaid position, they characterized. Result showed that has characteristic angle 1 z 3, 4= 40°, 320°, 280° respectively. Energy ofphalerin 18,7625 kkal/mol. 51-phalern similarity...
<p>TSH IRMA kit is a used for the determination of TSH (Thyroid Stimulating Hormone) levels in human blood serum. Thyroid hormone that our bodies need growth brain, bone and other tissues regulate metabolism body.<strong> </strong>TSH normal range adult 0.4-4.5 mIU/L, whereas baby about 3.0-18.0 mIU/L. would affect quality optimal children if disturbed. Therefore, assay needs to be determined know whether function thyroid gland works normally or not. Detection can performed...
<p>Immunoradiometric assay (IRMA) is a method of analysis based on immunological reactions antigens-antibodies binding. This highly specific and sensitive was used for in vitro diagnosis small quantity sample. Center Radioisotope Radiopharmaceutical Technology, BATAN has developed Thyroglobulin IRMA Kit using coated tube that can determine thyroglobulin levels microgram quantities. Coated made with immobilisation anti into polistyrene tube. Development kit performed through several...